5 completed, 1 recruiting, 1 terminated, 1 unknown. 6 Phase 3, 3 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 4, Terminated 1, Unknown 1 |
| Phase 2 | 3 | Completed 2, Recruiting 1 |
| Phase 1 | 2 | Completed 1, Recruiting 1 |
Follow Amsacrine: new trials by email Literature Review of Amsacrine trials Research Report on Amsacrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Venetoclax in Addition to Sequential Conditioning With Fludarabine / Amsacrine / Ara-C (FLAMSA) + Treosulfan for Allogeneic Blood Stem Cell Transplantation in Patients With MDS, CMML or sAML Venetoclax, Amsacrine, Ara-C - Myelodysplastic Syndromes, Secondary Acute Myeloid Leukemia | Phase 1 / Phase 2 | Recruiting | Heinrich-Heine University, Duesseldorf | 38 | 2023-06-26 | 2026-09-16 |
| Dexamethasone in Refractory or First Relapsed Acute Myeloid Leukemia Dexamethasone, Amsacrine, Cytarabine - Relapsed or Refractory Acute Myeloid Leukemia | Phase 3 | Terminated | University Hospital, Toulouse | 73 | 2020-01-13 | 2025-04-10 |
| Clofarabine or High-Dose Cytarabine and Pegaspargase in Children with ALL Amsacrine, Clofarabine, Cyclophosphamide - Leukemia | Phase 2 / Phase 3 | Completed | Universitätsklinikum Hamburg-Eppendorf | 745 | 2010-10-01 | 2024-12-11 |
| Laromustine, Daunorubicin, and Cytarabine in Treating Patients With Acute Myeloid Leukemia amsacrine, busulfan, cytarabine - Leukemia | Phase 1 / Phase 2 | Completed | Institut Paoli-Calmettes | 135 | 2009-01-01 | 2011-05-13 |
| Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia amsacrine, asparaginase, cytarabine - Leukemia, Myelodysplastic Syndromes | Phase 3 | Completed | Medical Research Council | 2000 | 1998-07-01 | 2013-12-04 |
| Combination Chemotherapy With or Without G-CSF in Treating Older Patients With Acute Myeloid Leukemia filgrastim, amsacrine, carmustine - Leukemia, Neutropenia | Phase 3 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 500 | 1995-12-01 | 2012-07-02 |
| Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia filgrastim, amsacrine, cyclophosphamide - Leukemia, Neutropenia | Phase 3 | Unknown | Medical Research Council | 2000 | 1994-01-01 | 2013-12-19 |
| A Randomized Phase III Study of Intensive Consolidation With High Dose Cytosine Arabinoside in Acute Myelogenous Leukemia (AML-8B) sargramostim, amsacrine, cytarabine - Leukemia | Phase 3 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 160 | 1986-11-01 | 2012-07-16 |
Leukemia (6) · Leukemia, Myeloid, Acute (3) · Leukemia, Erythroblastic, Acute (2) · Leukemia, Megakaryoblastic, Acute (2) · Leukemia, Monocytic, Acute (2) · Leukemia, Myelomonocytic, Acute (2) · Myelodysplastic Syndromes (2) · Neutropenia (2) · Anemia, Refractory, with Excess of Blasts (1) · Congenital Abnormalities (1) · Leukemia, Myelomonocytic, Chronic (1) · Leukemia, Promyelocytic, Acute (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1) · Recurrence (1)
European Organisation for Research and Treatment of Cancer - EORTC (2) · Medical Research Council (2) · Heinrich-Heine University, Duesseldorf (1) · Institut Paoli-Calmettes (1) · University Hospital, Toulouse (1) · Universitätsklinikum Hamburg-Eppendorf (1)
France (2) · Germany (2) · United Kingdom (2) · Italy (1)
Alan K. Burnett, MD, FRCP (1) · Franco Mandelli, MD (1) · Guido Kobbe, Prof. Dr. (1) · Martin Horstmann, MD (1) · Norbert Vey, MD (1) · Robert A. Zittoun, MD (1) · Roel Willemze, MD, PhD (1) · Tim O.B. Eden, MB, BS, FRCPE, FRCP, FRCPCH, F (1)
PMID 15761020, PMID 16932345, PMID 17339189, PMID 20038732, PMID 8683249
2009 (1)