72 completed, 12 unknown, 8 terminated, 6 recruiting. 106 Phase 2, 19 Phase 1, 8 Phase 3.
Follow Agranulocytosis: new trials by email Literature Review of Agranulocytosis trials Research Report on Agranulocytosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Restrictive Versus Standard Antibiotic Treatment During CAR-T Therapy ceftazidime, ciprofloxacin, Standard-of-Care Antibiotic Strategy - Large B-Cell Lymphoma (LBCL), Multiple Myeloma (MM) | Phase 2 | Not yet recruiting | Zealand University Hospital | 150 | 2027-03-01 | 2026-09-25 |
| Evaluation of Antibiotic Prophylaxis in Myelodysplastic Syndromes and Acute Myeloid Leukemia (MYELO-CAN:ABX) Levofloxacin, Usual Care - Myeldysplastic Syndrome (MDS), MYELOPROLIFERATIVE DISORDER (P Vera, CMML, ET) | Phase 2 | Not yet recruiting | University of Manitoba | 75 | 2026-09-01 | 2026-06-29 |
| Phase II Study of QLC2519 in Pediatric Solid Tumor Participants Albipagrastim alf - Pediatric Malignant Solid Tumor, Febrile Neutropenia (FN) | Phase 2 | Recruiting | Qilu Pharmaceutical Co., Ltd. | 18 | 2026-06-26 | 2026-07-24 |
| the Efficacy of Leucogen in Preventing the Risk of Ribociclib-Associated Neutropenia in Early Breast Cancer Treat Regimen - Leucogen, Ribociclib | Phase 2 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 97 | 2026-01-07 | 2026-09-28 |
| BETWEEN: Biweekly Bevacizumab + Trifluridine/Tipiracil to Reduce Grade 3-4 Neutropenia in mCRC Patients Trifluridine/tipiracil, Bevacizumab - Metastatic Colorectal Cancer | Phase 2 | Not yet recruiting | GERCOR - Multidisciplinary Oncology Cooperative Group | 162 | 2025-09-01 | 2025-07-17 |
| Clinical Study of Thiopegfilgrastim for Preventing Bone Marrow Suppression in Thoracic Tumor Chemoradiotherapy Mecapegfilgrastim injection, Oral or short-acting granulocyte-stimulating agents - Myelosuppression, Thoracic Neoplasms | Phase 2 | Recruiting | Affiliated Hospital of Nantong University | 30 | 2025-08-01 | 2025-12-11 |
| Luspatercept for Clonal Cytopenias of Uncertain Significance Luspatercept - CCUS Clonal Cytopenia of Undetermined Significance, Anemia | Phase 2 | Recruiting | Weill Medical College of Cornell University | 50 | 2025-03-25 | 2026-03-24 |
| Prospective Evaluation of Xerava Prophylaxis in Hematological Malignancy Patients With Prolonged Neutropenia Eravacycline - Hematological Malignancy, Neutropenia | Phase 2 | Recruiting | West Virginia University | 55 | 2024-02-19 | 2026-04-16 |
| A Study of Efbemalenograstim Alfa Injection for Stage IIIB or IV NSCLC Recieving Moderate-risk Febrile Neutropenia (FN) Chemotherapy Regimen With Risk Factors Efgbemalenograstim alfa - Non Small Cell Lung Cancer | Phase 2 | Unknown | Tianjin Medical University Cancer Institute and Hospital | 99 | 2023-12-31 | 2023-11-22 |
| Umbilical Cord Derived Mesenchymal Stem Cells for Treatment-induced Myelosuppression in Hematologic Malignancies umbilical cord derived mesenchymal stem cells - Hematologic Neoplasms, Neutropenia | Phase 1 / Phase 2 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 181 | 2023-01-01 | 2023-01-05 |
| Study of Trilaciclib and Lurbinectidin Trilaciclib, Lurbinectedin - Lung Cancer, Small-cell Lung Cancer | Phase 2 | Recruiting | UNC Lineberger Comprehensive Cancer Center | 30 | 2022-10-12 | 2026-09-21 |
| Effect of Tranexamic Acid and Calcium Dobesilate for Bleeding of Endometrial Origin Tranexamic Acid, Calcium dobesilate (Doxium) - Heavy. Mentrual Bleeding, Abormal utèrine Bleeding | Phase 2 / Phase 3 | Completed | District Headquarters Teaching Hospital Sahiwal | 100 | 2022-01-01 | 2024-11-27 |
| A Study of Mavorixafor in Participants With Congenital Neutropenia and Chronic Idiopathic Neutropenia Disorders Mavorixafor - Neutropenia | Phase 1 / Phase 2 | Completed | X4 Pharmaceuticals | 32 | 2021-10-16 | 2025-08-06 |
| Injection Regimen Trial of PEG-rhG-CSF During Breast Cancer Chemotherapy Day 7 regimen, Day 3 regimen - Breast Cancer | Phase 2 | Completed | The First Affiliated Hospital with Nanjing Medical University | 160 | 2021-07-13 | 2023-02-23 |
| LONsurf and G-CSF Use: Being On A Right Dose-intensity to Optimize Treatment Efficacy Trifluridine/Tipiracil - Metastatic Colorectal Cancer | Phase 2 | Active not recruiting | GERCOR - Multidisciplinary Oncology Cooperative Group | 176 | 2020-05-20 | 2025-08-19 |
| Pentaglobin in CRE and PA Neutropenic Infections Pentaglobin - Septic Shock | Phase 2 | Active not recruiting | Gruppo Italiano Trapianto di Midollo Osseo | 120 | 2019-12-06 | 2025-01-06 |
| Newton Study (NEW Dosing MainTenance Therapy Ovarian CaNcer) Niraparib - Ovarian Cancer, Fallopian Tube Cancer | Phase 2 | Terminated | Mario Negri Institute for Pharmacological Research | 83 | 2019-11-13 | 2025-01-17 |
| Anakinra: Efficacy in the Management of Fever During Neutropenia and Mucositis in ASCT - A Randomized Controlled Trial Anakinra, Placebos - Multiple Myeloma | Phase 2 | Completed | Radboud University Medical Center | 88 | 2019-11-04 | 2024-11-18 |
| Study on the Efficacy and Safety of PEG-rhG-CSF in Preventing Neutropenia During Concurrent Chemoradiotherapy of Cervical Cancer PEG-rhG-CSF, rhG-CSF - Cervical Cancer | Phase 2 | Completed | Chongqing University Cancer Hospital | 60 | 2018-08-01 | 2023-09-06 |
| Management of Severe Chemotherapy-induced Neutropenia in Advanced Breast Cancer EC-18 - Febrile Neutropenia | Phase 1 / Phase 2 | Completed | Enzychem Lifesciences Corporation | 28 | 2017-10-30 | 2023-08-15 |
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Neutropenia (92) · Febrile Neutropenia (22) · Breast Neoplasms (17) · Thrombocytopenia (16) · Anemia (13) · Leukemia (11) · Infections (10) · Neoplasms (9) · Leukemia, Myeloid, Acute (8) · Anemia, Aplastic (6) · Fever (6) · Myelodysplastic Syndromes (6) · Autoimmune Diseases (5) · Colorectal Neoplasms (5) · Lymphoma (5)
Hemic and Lymphatic Diseases (106) · Leukocyte Disorders (106) · Cytopenia (103) · Hematologic Diseases (103) · Leukopenia (102) · Neoplasms (52) · Neoplasms by Site (34) · Neoplasms by Histologic Type (27) · Immune System Diseases (26) · Pathological Conditions, Signs and Symptoms (23) · Skin and Connective Tissue Diseases (21) · Skin Diseases (19) · Blood Platelet Disorders (18) · Breast Diseases (17)
Filgrastim (17) · pegfilgrastim (15) · Cyclophosphamide (8) · Cytarabine (5) · Cyclosporine (4) · Docetaxel (4) · Etoposide (4) · pegylated granulocyte colony-stimulating factor (4) · Alemtuzumab (3) · Doxorubicin (3) · Granulocyte Colony-Stimulating Factor (3) · Methotrexate (3) · Amifostine (2) · Anidulafungin (2) · Cefepime (2)
Amgen (8) · National Heart, Lung, and Blood Institute (NHLBI) (8) · EVIVE Biotechnology (3) · Memorial Sloan Kettering Cancer Center (3) · National Cancer Institute (NCI) (3) · Alliance for Clinical Trials in Oncology (2) · GERCOR - Multidisciplinary Oncology Cooperative Group (2) · M.D. Anderson Cancer Center (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Pfizer (2) · Radboud University Medical Center (2) · AM-Pharma (1) · Affiliated Hospital of Nantong University (1) · Asan Medical Center (1) · AviGenics (1)
United States (42) · China (15) · South Korea (6) · Netherlands (5) · Canada (4) · France (4) · Germany (4) · Russia (4) · Australia (3) · Poland (3) · Bulgaria (2) · Denmark (2) · Georgia (2) · Hungary (2) · Israel (2)
Danielle M Townsley, M.D. (4) · Cynthia E Dunbar, M.D. (2) · David H McDermott, M.D. (2) · Nicole Blijlevens, MD PhD (2) · Thomas J. Walsh, MD (2) · A Vulto, PhD (1) · Aaron Cumpston, PharmD, BCOP (1) · Aleksei G. Manikhas, MD PhD (1) · Alison E Gardner, PhD (1) · Andrea Pietro Sponghini (1) · Antonius Miller, MD (1) · Bart Biemond, MD PhD (1) · Bart JA Rijnders, MD, PhD (1) · Beverley A de Valois, PhD (1)
PMID 29958797, PMID 34724566, PMID 16382125, PMID 17170128, PMID 18156492, PMID 18616811, PMID 18827613, PMID 19208097, PMID 20045791, PMID 20431381, PMID 21890643, PMID 22067384, PMID 23909727, PMID 24523241, PMID 24723677, PMID 25185712, PMID 26036623, PMID 26504182, PMID 26765645, PMID 27658437, PMID 28339500, PMID 28395844, PMID 29119726, PMID 29140155, PMID 29524595, PMID 29573207, PMID 29674506, PMID 30992268, PMID 31022078, PMID 31220256, PMID 32236406, PMID 32330244, PMID 33030582, PMID 33225965, PMID 33384016, PMID 33789616, PMID 34078317, PMID 34156898, PMID 34858760, PMID 35546555, PMID 37561579, PMID 37641932, PMID 38194162, PMID 39533204, PMID 40330596, PMID 41066031, PMID 41950571, PMID 42606118, PMID 9771955
2014 (1), 2018 (1), P01CA075606 (1), P30CA036727 (1), R01HD061265 (1), U10CA031946 (1), U10CA032102 (1)