32 completed, 6 unknown, 1 active not recruiting, 1 not yet recruiting. 16 Not applicable, 9 Phase 4, 5 Phase 1, 5 Phase 2, 4 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution, Placebo - Acute Mountain Sickness | Phase 4 | Not yet recruiting | Insel Gruppe AG, University Hospital Bern | 30 | 2027-06-01 | 2026-07-01 |
| Voluntary Isocapnic Hyperpnea in Hypoxia to Mitigate Acute Mountain Sickness VIH - Acute Mountain Sickness | Not applicable | Active not recruiting | Institute of Sport - National Research Institute, Poland | 20 | 2025-06-01 | 2025-08-20 |
| Prochlorperazine Maleate Versus Placebo for the Prophylaxis of Acute Mountain Sickness Prochlorperazine Maleate, Placebo - Acute Mountain Sickness | Phase 2 | Completed | University of Colorado, Denver | 57 | 2024-08-05 | 2024-09-19 |
| EleVation carE: a Randomized Controlled Trial on the Prevention of Acute Mountain Sickness With Suxiao Jiuxin Pill Suxiao Jiuxin Pill, Placebo - Acute Mountain Sickness | Phase 2 / Phase 3 | Unknown | Peking University First Hospital | 168 | 2024-08-01 | 2024-08-12 |
| HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men Acetazolamide, Placebo - Acute Mountain Sickness | Phase 4 | Completed | University of Zurich | 303 | 2024-07-15 | 2026-01-23 |
| HighCycle Study: Effect of High Altitude on Acute Mountain Sickness in Women Related to Their Menstrual Cycle Phase Exposure to 3600 m - Acute Mountain Sickness | Completed | University of Zurich | 91 | 2024-07-15 | 2026-06-05 | |
| CO2 Supplement for Treatment of Acute Mountain Sickness Breathing with CO2 during daytime and night at high altitude, Sleep and doing exercise test under inhalation of air - Acute Mountain Sickness, High Altitude | Not applicable | Completed | State Key Laboratory of Respiratory Disease | 46 | 2024-06-07 | 2024-12-18 |
| The Effect of Continuous Positive Pressure Ventilation on Symptoms of Acute Mountain Sickness Continuous positive airway pressure (CPAP), ResMed AirMini - Acute Mountain Sickness | Not applicable | Unknown | University of Colorado, Denver | 75 | 2024-03-10 | 2023-11-22 |
| Risk Factors Associated With High Altitude Sickness: A Case-Control Study Acute Mountain Sickness, High Altitude Pulmonary Edema | Completed | B.P. Koirala Institute of Health Sciences | 126 | 2023-07-01 | 2024-08-06 | |
| The Effects of Intermittent Hypoxia on Acute Hypoxic Injury Intermittent Hypoxia, Sham Intermittent Hypoxia - Acute Mountain Sickness | Not applicable | Unknown | Capital Medical University | 100 | 2023-03-01 | 2023-03-29 |
| Effect of Inhalation of Low Dose CO2 on Exercise Performance at High Altitude Exercise under inhalation CO2, Exercise under inhalation ambient air - High Altitude, Inhalation; Gas | Not applicable | Completed | State Key Laboratory of Respiratory Disease | 28 | 2023-02-15 | 2023-05-18 |
| Optimization Strategy for the Prevention of AMS by RIPC Combined With Acetazolamide Acetazolamide, Doctormate® (twice daily for 6 days), Doctormate® (forth daily for 3 days) - Acute Mountain Sickness | Phase 4 | Completed | Ji Xunming,MD,PhD | 252 | 2021-12-01 | 2022-10-03 |
| Efficacy of Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness Immediate descent from altitude., Diphenhydramine, Prochlorperazine 10 mg - AMS, Acute Mountain Sickness | Phase 4 | Completed | CHRISTUS Health | 30 | 2021-05-20 | 2024-05-28 |
| Colorado-Oregon Altitude Study Erythropoietin, Iron sucrose (Venofer), Sterile Sodium Chloride - Acute Mountain Sickness | Phase 4 | Completed | University of Oregon | 121 | 2021-02-17 | 2023-03-10 |
| Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude FP, Placebo, High altitude - Gastrointestinal Injury, Acute Mountain Sickness | Not applicable | Completed | United States Army Research Institute of Environmental Medicine | 33 | 2019-10-06 | 2022-12-23 |
| Sickness Evaluation at Altitude With Acetazolamide at Relative Doses Acetazolamide Pill - Acute Mountain Sickness | Phase 1 | Completed | Stanford University | 108 | 2019-08-09 | 2019-10-22 |
| Sickness Evaluation at Altitude With Acetazolamide at Relative Dosages Acetazolamide - Acute Mountain Sickness | Phase 1 | Completed | Stanford University | 105 | 2018-08-04 | 2018-11-20 |
| Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years ACETAZOLAMIDE oral capsule, Placebo oral capsule - Acute Mountain Sickness | Phase 4 | Completed | University of Zurich | 349 | 2018-05-15 | 2021-05-13 |
| Decompression Tables for Diving at Altitude Pressure, Breathing Gas - Decompression Sickness, Acute Mountain Sickness | Not applicable | Completed | Duke University | 103 | 2018-02-13 | 2021-12-14 |
| Altitude Sickness Prevention With Ibuprofen Relative to Acetazolamide and Treatment Efficacy Ibuprofen, Acetazolamide - Acute Mountain Sickness | Phase 1 | Completed | Grant S Lipman | 92 | 2017-08-12 | 2018-11-26 |
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Altitude Sickness (41) · Hypoxia (6) · Respiratory Aspiration (4) · Mucopolysaccharidosis IV (2) · Decompression Sickness (1) · Environmental Illness (1) · Hyperventilation (1) · Migraine Disorders (1) · Motor Activity (1) · Sleep Apnea, Central (1)
Respiration Disorders (41) · Respiratory Tract Diseases (41) · Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (7) · Signs and Symptoms, Respiratory (7) · Pathologic Processes (4) · Carbohydrate Metabolism, Inborn Errors (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Connective Tissue Diseases (2) · Genetic Diseases, Inborn (2) · Lysosomal Storage Diseases (2) · Metabolic Diseases (2) · Metabolism, Inborn Errors (2) · Mucinoses (2) · Mucopolysaccharidoses (2)
Acetazolamide (8) · Erythropoietin (2) · Ibuprofen (2) · Prochlorperazine (2) · Budesonide (1) · Continuous Positive Airway Pressure (1) · Diphenhydramine (1) · Ferric Oxide, Saccharated (1) · Metoclopramide (1) · Pressure (1) · Sea Level Rise (1) · Sildenafil Citrate (1) · Starch (1) · Sugars (1) · Theophylline (1)
Stanford University (4) · University of Zurich (4) · Altitude Physiology Expeditions (2) · Heidelberg University (2) · Insel Gruppe AG, University Hospital Bern (2) · State Key Laboratory of Respiratory Disease (2) · University of Colorado, Denver (2) · B.P. Koirala Institute of Health Sciences (1) · CHRISTUS Health (1) · Capital Medical University (1) · Chang Gung Memorial Hospital (1) · Duke University (1) · Goethe University (1) · Grant S Lipman (1) · Institut de Formation et de Recherche en Médecine de Montagne (1)
United States (10) · China (5) · Nepal (5) · Germany (4) · Kyrgyzstan (3) · Switzerland (2) · Austria (1) · France (1) · Italy (1) · Poland (1) · South Korea (1) · Taiwan (1) · United Kingdom (1)
Grant S Lipman, MD (2) · Konrad E Bloch, MD (2) · Michael Furian, Prof. Dr. (2) · Talant Sooronbaev, Prof. Dr. (2) · Yuanming Luo, PhD (2) · Andreas Huber, Prof. Dr. med. (1) · Buddha Basnyat, MD PhD (1) · Carrie Jurkiewicz, MD (1) · Christoph Dehnert, MD (1) · Elan Small, MD (1) · Gabor Szalay, Dr. med. (1) · Giacomo Strapazzon, MD (1) · J. Philip Karl, PhD (1) · James M Muhm, MD, MPH (1) · Kai Schommer, MD (1)
PMID 23270443, PMID 17611205, PMID 19273551, PMID 19326598, PMID 21962063, PMID 23098412, PMID 24176010, PMID 24465370, PMID 24616593, PMID 25950723, PMID 28668540, PMID 28890439, PMID 30419226, PMID 32479750, PMID 36356042, PMID 38166913, PMID 38296630, PMID 39574186, PMID 39778901, PMID 42429551