12 completed, 12 unknown, 8 recruiting, 3 withdrawn. 23 Not applicable, 3 Phase 4, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 23 | Completed 9, Recruiting 5, Unknown 4, Withdrawn 3, Active not recruiting 1, Terminated 1 |
| Phase 4 | 3 | Unknown 2, Completed 1 |
| Phase 1 | 1 | Not yet recruiting 1 |
| Phase 3 | 1 | Unknown 1 |
Follow ACL: new trials by email Literature Review of ACL trials Research Report on ACL
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Restoration of Knee Extension After ACL Reconstruction Standard Physical Therapy, Ermi Knee Extensionater - Knee, ACL | Phase 1 | Not yet recruiting | University of Alabama at Birmingham | 58 | 2026-12-01 | 2026-10-15 |
| Interventions to Enhance Quadriceps Output After ACLR NMES, Vibration - ACL | Not applicable | Recruiting | University of Wisconsin, Madison | 22 | 2026-10-01 | 2026-10-01 |
| VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR) VibraCool mechanical stimulation and neuromodulatory therapeutic device, Cryocompression (Game Ready, Bregs) device, Standard ice packs - ACL, Opioid Use | Not applicable | Recruiting | Columbia University | 130 | 2026-06-01 | 2026-01-07 |
| Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction Placebo Split-Belt Training, Split-Belt Training - ACL, Anterior Cruciate Ligament | Not applicable | Recruiting | University of Michigan | 9 | 2025-08-13 | 2026-09-15 |
| Outcomes and Complication Rates of Anterior Cruciate Ligament Reconstruction Using the "Over-the-top" Technique Combined With Lateral Extra-articular Tenodesis in Patients Over 50 Years Old, Compared With a Control Group of Patients Under 30 ligament reconstruction using the single-bundle "over-the-top" technique - ACL, LET | Recruiting | Stefano Zaffagnini | 164 | 2025-07-13 | 2026-09-04 | |
| Long-term Clinical and Radiographic Results of Revision Anterior Cruciate Ligament Reconstruction Using a Single-bundle Technique and External Tenodesis With Achilles Tendon Allograft. ACL, LET | Recruiting | Stefano Zaffagnini | 59 | 2025-03-19 | 2026-07-02 | |
| Conservative Treatment With Blood Flow Restriction in Patients With Total ACL Rupture. "Randomized Clinical Trial" Blood Flow Restriction, Brace - ACL, ACL - Anterior Cruciate Ligament Rupture | Not applicable | Recruiting | European University Cyprus | 20 | 2025-02-01 | 2025-04-03 |
| Primary ACL Reconstruction in Patient Over 40 Years: Allograft Versus Autograft ACL reconstruction - ACL, ACL Injury | Unknown | Università Vita-Salute San Raffaele | 40 | 2024-12-01 | 2024-09-05 | |
| Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction Split-belt Training, Tied-Belt Training - ACL, ACL Injury | Not applicable | Completed | University of Michigan | 32 | 2024-10-29 | 2026-05-05 |
| Trunk and Lower Limb Muscle Contributions to ACL Loading During Single-Leg Landing ACL | Completed | Universiti Sains Malaysia | 40 | 2024-06-12 | 2026-05-27 | |
| Anterior Cruciate Ligament Study Anterior cruciate ligament reconstruction - ACL Injury, ACL | Recruiting | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | 370 | 2023-12-06 | 2024-01-08 | |
| Blood Flow Restriction Following ACLR Blood Flow Restriction Training, Sham Blood Flow Restriction Training - Anterior Cruciate Ligament Injuries, ACL | Not applicable | Withdrawn | Rush University Medical Center | 2023-12-01 | 2023-08-07 | |
| Exploring Prolonged AMR in ACL Reconstructed Patients Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture | Unknown | University Ghent | 190 | 2023-10-15 | 2024-07-01 | |
| Comparison of Semitendinosus and Quadriceps Grafts for Anterior Cruciate Ligament Reconstruction ACL reconstruction - ACL, ACL Injury | Not applicable | Completed | Universidad de Granada | 54 | 2023-10-01 | 2026-05-06 |
| Exparel vs Block for ACL Reconstruction Exparel 30 mL, 0.5% bupivacaine, Dexamethasone - ACL, Postoperative Pain | Phase 4 | Unknown | Rothman Institute Orthopaedics | 154 | 2023-08-21 | 2024-06-21 |
| Genicular Nerve Blocks for Anterior Cruciate Ligament Knee Surgery Genicular Nerve Block with bupivacaine and preservative free dexamethasone - ACL, Anterior Cruciate Ligament Injuries | Phase 4 | Completed | Hospital for Special Surgery, New York | 192 | 2023-01-12 | 2026-01-26 |
| Mindfulness and ACL Surgery Healthy Minds Program (HMP) App - ACL, ACL Injury | Not applicable | Active not recruiting | University of Wisconsin, Madison | 47 | 2022-07-01 | 2026-04-29 |
| Playmaker 3D Printed Knee Extender 3D printed knee extender device, Standard Prehabilitation Education - ACL, ACL Injury | Not applicable | Terminated | Sanford Health | 36 | 2022-06-15 | 2024-03-08 |
| Evaluation Of Clinical Results And Imaging Of Anterior Cruciate Ligament Reconstruction With Orthopure Xt Orthopure - ACL, ACL Injury | Not applicable | Completed | Istituto Ortopedico Rizzoli | 10 | 2022-04-12 | 2025-09-12 |
| Reduced Knee Flexion Strength 18 Years After ACL Reconstruction in Hamstring Group Compared to Patellar Tendon Group ACL reconstruction - ACL, ACL Injury | Completed | St. Olavs Hospital | 114 | 2022-03-14 | 2025-06-06 |
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Anterior Cruciate Ligament Injuries (20) · Pain, Postoperative (3) · Knee Injuries (1) · Patient Satisfaction (1)
Leg Injuries (21) · Wounds and Injuries (21) · Knee Injuries (20) · Neurologic Manifestations (3) · Pain (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Postoperative Complications (3) · Signs and Symptoms (3) · Behavior (1) · Health Behavior (1) · Treatment Adherence and Compliance (1)
Blood Flow Restriction Therapy (2) · Bupivacaine (2) · Acetaminophen (1) · Acupuncture Therapy (1) · Amyloid (1) · Anterior Cruciate Ligament Reconstruction (1) · Braces (1) · Calcium Dobesilate (1) · Dexamethasone (1) · Hyaluronic Acid (1) · Naproxen (1) · Oxycodone (1) · Resistance Training (1) · Saline Solution (1) · Standard of Care (1)
Hospital for Special Surgery, New York (2) · Rothman Institute Orthopaedics (2) · Sports Surgery Clinic, Santry, Dublin (2) · Stefano Zaffagnini (2) · University of Michigan (2) · University of Wisconsin, Madison (2) · Columbia University (1) · European University Cyprus (1) · GCS Ramsay Santé pour l'Enseignement et la Recherche (1) · I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio (1) · Istituto Ortopedico Rizzoli (1) · Kaohsiung Veterans General Hospital. (1) · Karolinska Institutet (1) · Laval University (1) · Maidstone & Tunbridge Wells NHS Trust (1)
United States (16) · Italy (5) · Canada (2) · Ireland (2) · Belgium (1) · Cyprus (1) · France (1) · Malaysia (1) · Norway (1) · Spain (1) · Sweden (1) · Switzerland (1) · Taiwan (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Chandramouli Krishnan, PT, PhD (2) · Riann M Palmieri-Smith, PhD, ATC (2) · Amit Momaya, MD (1) · Andrew Watson, MD, MS (1) · Brian G Ragan, Ph.D. (1) · Conrad M Gabler, B.S. (1) · Daniel Cobian, DPT, PhD (1) · David H Kim, MD (1) · Eric Strauss, MD (1) · Jashvant Poeran, MD/PhD (1) · Jon O. Drogset, PhD (1) · Lynn Snyder-Mackler, PT, ATC, ScD (1) · Manuel Arroyo-Morales, PhD PT, MD (1) · Nathan Skelley, MD (1)
PMID 18292988, PMID 23302260, PMID 30944945, PMID 33580345, PMID 33872056, PMID 34471447, PMID 34776148, PMID 37154412, PMID 37316199, PMID 37347015, PMID 39221503, PMID 41327334, PMID 41522461, PMID 42544937
R21AR082643 (2), R44HD068054 (1)