13 completed, 3 recruiting. 16 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 16 | Completed 13, Recruiting 3 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Changes in MTX-PG Concentrations During Subcutaneous MTX Therapy in Patients With Rheumatoid Arthritis(COSMOS Study) Methotrexate (MTX) - Rheumatoid Arthritis (RA) | Phase 4 | Recruiting | Keio University | 100 | 2025-04-10 | 2025-04-06 |
| Lemborexant in Delayed Sleep Phase Syndrome Lemborexant, Placebo - Delayed Sleep Phase Syndrome | Phase 4 | Recruiting | University of California, San Francisco | 15 | 2023-03-13 | 2026-06-05 |
| Lemborexant in Delayed Sleep Phase Syndrome Lemborexant, Placebo - Delayed Sleep Phase Syndrome | Phase 4 | Recruiting | Stanford University | 86 | 2022-02-01 | 2026-10-26 |
| Evaluation of the Optimal MTX Dose as an Add-on Therapy to Adalimumab for RA Patients in Japan, South Korea and Taiwan Methotrexate, Adalimumab - Rheumatoid Arthritis | Phase 4 | Completed | Keio University | 300 | 2018-04-18 | 2025-03-06 |
| A Post-Marketing Clinical Study of Aricept in Patients With Dementia With Lewy Bodies (DLB) E2020, Placebo - Dementia, Lewy Body, Lewy Body Disease | Phase 4 | Completed | Eisai Co., Ltd. | 160 | 2015-03-01 | 2019-01-08 |
| A Study of Donepezil Hydrochloride in Patients With Dementia Associated With Cerebrovascular Disease Donepezil hydrochloride, Donepezil matching placebo - Dementia Associated With Cerebrovascular Disease | Phase 4 | Completed | Eisai Co., Ltd. | 302 | 2013-08-05 | 2020-01-10 |
| Pharmacological Effect of Lysozyme for Chronic Obstructive Pulmonary Disease and Asthma With Sputum Symptom lysozyme 90 mg, Placebo - Chronic Obstructive Pulmonary Disease, Asthma | Phase 4 | Completed | Eisai Co., Ltd. | 48 | 2012-10-01 | 2014-07-18 |
| Effects of Lysozyme on Acute Exacerbation of Chronic Obstructive Pulmonary Disease : A Randomised Placebo-Controlled Study Lysozyme hydrochloride, Placebo - COPD | Phase 4 | Completed | Eisai Co., Ltd. | 408 | 2012-08-01 | 2015-10-21 |
| Efficacy and Safety of Teprenone in Patients With Acute Gastritis, Acute Gastric Lesion of Chronic Gastritis With Acute Exacerbation or Gastric Ulcer Selbex - Acute Gastritis, Gastric Ulcer | Phase 4 | Completed | Eisai Co., Ltd. | 1184 | 2010-05-01 | 2013-04-01 |
| Safety and Efficacy of Mecobalamin Injection in Peripheral Neuropathies Patients (Study JGAZSY091109) Mecobalamin IV Injection, Mecobalamin IM injection, Mecobalamin IV or IM injection - Peripheral Neuropathy | Phase 4 | Completed | Eisai Co., Ltd. | 1072 | 2010-04-01 | 2012-11-07 |
| Pharmacokinetics Study of Donepezil HCl in Subjects Receiving Haemodialysis. donepezil HCl - End-Stage Renal Disease | Phase 4 | Completed | Eisai Co., Ltd. | 6 | 2010-02-01 | 2013-05-14 |
| Post-marketing Study of Monteplase ("Cleactor") in Patients With Acute Pulmonary Embolism Monteplase - Pulmonary Embolism | Phase 4 | Completed | Eisai Inc. | 5 | 2007-05-01 | 2018-10-18 |
| Effects of Combination Therapy With Alpha-1 Blocker (Bunazosin or Doxazosin) in the Treatment of Patients With Mild to Moderate Essential Hypertension Bunazosin, Doxazosin, Valsartin - High Blood Pressure | Phase 4 | Completed | Eisai Inc. | 93 | 2005-10-01 | 2013-05-14 |
| Efficacy and Safety of Donepezil Hydrochloride (Aricept) in Vascular Dementia donepezil hydrochloride (Aricept) - Vascular Dementia | Phase 4 | Completed | Eisai Inc. | 36 | 2005-09-01 | 2012-05-04 |
| A Double-blind, Comparative Study in Patients With Gastric Ulcer to Evaluate the Efficacy of Combination Use of E0671 and Rabeprazole Sodium E0671, rabeprazole sodium, E0671 placebo - Stomach Ulcer | Phase 4 | Completed | Eisai Co., Ltd. | 520 | 2005-08-01 | 2018-10-29 |
| The Role of Methycobalamin in Early Dementia Patients With Vitamin B12 Deficiency and Hyperhomocysteinaemia. Mecobalamin - Dementia With Vitamin B12 Deficiency | Phase 4 | Completed | Eisai Co., Ltd. | 2003-03-01 | 2019-02-19 |
Arthritis, Rheumatoid (2) · Pulmonary Disease, Chronic Obstructive (2) · Sleep Disorders, Circadian Rhythm (2) · Stomach Ulcer (2) · Asthma (1) · Autoimmune Diseases (1) · Connective Tissue Diseases (1) · Dementia (1) · Dementia, Vascular (1) · Diabetic Neuropathies (1) · Embolism (1) · Hypertension (1) · Kidney Failure, Chronic (1) · Lewy Body Disease (1) · Peripheral Nervous System Diseases (1)
Donepezil (4) · Methotrexate (2) · lemborexant (2) · Adalimumab (1) · Doxazosin (1) · Injections, Intramuscular (1) · Muramidase (1) · Rabeprazole (1) · Valsartan (1) · bunazosin (1) · mecobalamin (1) · monteplase (1)
Japan (8) · China (3) · South Korea (2) · Taiwan (2) · United States (2) · Philippines (1)
Andrew D Krystal, MD, MS (2) · Emmanuel Mignot, MD, PhD (1) · Hirotake Ishigami (1) · Jacqueline Dominguez (1) · Jvming Lu (1) · Kai Shibata (1) · Megumi Ohdake (1) · Romeo Chu (1) · Takashi Musha (1) · Toshihisa Arai (1) · Ya-hui Cheng (1) · Yaozong Yuan (1) · Yukinori Sakata (1) · Yuko Kaneko, MD, PhD (1)