36 completed, 5 unknown, 3 terminated, 2 withdrawn. 14 Phase 4, 11 Phase 2, 10 Phase 1, 5 Not applicable, 5 Phase 3.
Follow Doxazosin: new trials by email Literature Review of Doxazosin trials Research Report on Doxazosin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treating Nightmares in Posttraumatic Stress Disorder With Clonidine and Doxazosin Clonidine, Doxazosin, Placebo - Posttraumatic Stress Disorder | Phase 2 | Suspended | Charite University, Berlin, Germany | 53 | 2022-06-17 | 2025-08-13 |
| Targeting Stress-Induced Alcohol Relapse Risk With Doxazosin XL Doxazosin XL, Placebo - Alcohol Use Disorder | Phase 1 | Withdrawn | The University of Texas Health Science Center, Houston | 2022-05-12 | 2022-09-01 | |
| Influence of the Autonomic Nervous System in Response to Exercise in Hypertensive Individuals α1-adrenergic block, Placebo - Autonomic Nervous System, Hypertension | Not applicable | Unknown | Instituto de Cardiologia do Rio Grande do Sul | 39 | 2020-04-30 | 2020-05-01 |
| ACEI or ARB and COVID-19 Severity and Mortality in US Veterans ACEI/ARB, Non-ACEI/ARB, ACEI - Hypertension, COVID | Completed | University of Utah | 22213 | 2020-01-19 | 2021-04-28 | |
| Alpha-1 Blockade for Alcohol Use Disorder (AUD) Doxazosin, Placebo - Alcohol Use Disorder (AUD) | Phase 2 | Active not recruiting | Brown University | 184 | 2019-08-19 | 2026-09-23 |
| A Randomized Controlled Trial of Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD Doxazosin Mesylate, Extended Release, Placebo - Stress Disorders, Post-Traumatic | Phase 2 | Unknown | San Francisco Veterans Affairs Medical Center | 80 | 2018-04-15 | 2024-05-01 |
| Preoperative Alpha Blockade for Pheochromocytoma Phenoxybenzamine, Doxazosin - Pheochromocytoma, Paraganglioma | Phase 3 | Completed | University of California, Los Angeles | 39 | 2017-05-05 | 2023-11-20 |
| Testing Doxazosin to Treat Stress Mechanisms in Alcoholism Doxazosin, Placebo - Alcoholism | Phase 2 | Completed | University of Wisconsin, Madison | 61 | 2017-04-12 | 2021-03-18 |
| CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders doxazosin, placebo - Posttraumatic Stress Disorder, Alcohol Use Disorders | Phase 2 | Completed | VA Office of Research and Development | 144 | 2016-06-01 | 2021-05-13 |
| The Effects of Doxazosin and Nifedipine on Blood Pressure Variability and Uric Acid in Plasma in Hypertensive Patients Doxazosin, Nifedipine - Hypertension | Phase 2 / Phase 3 | Unknown | First Affiliated Hospital of Harbin Medical University | 30 | 2015-09-01 | 2016-07-28 |
| Complementary Combination Therapy for Cocaine Dependence Doxazosin, Modafinil, cocaine - Cocaine Dependence | Phase 1 | Completed | Baylor College of Medicine | 45 | 2015-08-01 | 2022-04-26 |
| Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse Doxazosin, Placebo - Cocaine Dependence | Phase 2 | Completed | VA Office of Research and Development | 43 | 2014-04-01 | 2020-02-20 |
| A Pilot Study to Assess the Effects of Doxazosin on Polysomnography in PTSD Doxazosin XL - Stress Disorders, Post-Traumatic | Phase 4 | Completed | San Francisco Veterans Affairs Medical Center | 15 | 2013-10-01 | 2016-10-20 |
| The Changes of Urine Growth Factors Level Silodosin - Benign Prostatic Hyperplasia | Early Phase 1 | Completed | En Chu Kong Hospital | 74 | 2013-05-31 | 2024-02-28 |
| Does Doxazosin Attenuate Stress-induced Smoking and Improve Clinical Outcomes? Doxazosin 4mg/day, Placebo, Doxazosin 8mg/day - Smoking | Phase 2 | Completed | Yale University | 35 | 2013-02-01 | 2018-02-20 |
| Antimuscarinics as the First-line Treatment for Male With IPSS-V/S≤1 Detrusitol 4 mg QD, Doxazosin 4 mg QD - Bladder Outlet Obstruction | Phase 4 | Completed | Buddhist Tzu Chi General Hospital | 395 | 2012-08-01 | 2014-06-25 |
| Cyclooxygenase-2 (COX-2) Inhibitor Reduces Serum Prostatic Specific Antigen (PSA) Levels Doxazosin 4 mg daily plus Celecoxib 200 mg every day (QD), Doxazosin 4 mg every day (QD) - Benign Prostatic Hyperplasia | Phase 2 | Completed | Buddhist Tzu Chi General Hospital | 140 | 2012-08-01 | 2014-07-15 |
| DOXAZOSIN FOR PTSD doxazosin, Perindopril, Placebo - PTSD | Phase 1 | Completed | Baylor College of Medicine | 30 | 2012-01-01 | 2022-04-26 |
| Phenoxybenzamine Versus Doxazosin in PCC Patients Phenoxybenzamine, Doxazosin - Pheochromocytoma | Phase 4 | Completed | University Medical Center Groningen | 134 | 2011-12-01 | 2024-09-19 |
| Doxazosin an a1 Antagonist for Alcohol Dependence Doxazosin, Placebo - Alcohol Dependence, Anxiety | Early Phase 1 | Completed | Brown University | 41 | 2011-11-01 | 2025-08-18 |
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Hypertension (15) · Prostatic Hyperplasia (7) · Substance-Related Disorders (7) · Alcoholism (5) · Cocaine-Related Disorders (5) · Stress Disorders, Post-Traumatic (5) · Cardiovascular Diseases (4) · Heart Diseases (3) · Anxiety Disorders (2) · Coronary Disease (2) · Diabetes Mellitus, Type 2 (2) · Lower Urinary Tract Symptoms (2) · Myocardial Infarction (2) · Parasomnias (2) · Pheochromocytoma (2)
Baylor College of Medicine (6) · Samsung Medical Center (3) · Brown University (2) · Buddhist Tzu Chi General Hospital (2) · San Francisco Veterans Affairs Medical Center (2) · University of Vigo (2) · VA Office of Research and Development (2) · Boehringer Ingelheim (1) · Charite University, Berlin, Germany (1) · Creighton University (1) · Donna Arnett, 257-5678 (1) · Eisai Inc. (1) · En Chu Kong Hospital (1) · First Affiliated Hospital of Harbin Medical University (1) · Hospital Authority, Hong Kong (1)
United States (22) · Taiwan (4) · South Korea (3) · China (2) · Japan (2) · Spain (2) · United Kingdom (2) · Brazil (1) · Denmark (1) · Germany (1) · Italy (1) · Netherlands (1) · Sweden (1) · Switzerland (1)
Anne Richards, MD, MPH (2) · Hann-Chorng Kuo, M.D. (2) · Ramon C Hermida, PhD (2) · A A. Franken, MD PhD (1) · Adam P Bress, PharmD, MS (1) · Barry Davis (1) · Bas Havekes, MD PhD (1) · Brian K. Auge, M.D. (1) · C B. Brouwer, MD PhD (1) · Carolina L Haass-Koffler, PHARMD, PHD (1) · Cheng Cheng Wang, M.D Ph.D (1) · Chi Wai Cheng, Dr (1) · Claus Roehrborn (1) · Daryl I Shorter, MD (1) · Donna Arnett (1)
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P50DA018197 (4), 1IK2CX000946-01 (1), 2008 (1), P20RR011104 (1), R01AA024388 (1), R01HL034767 (1), R01HL048013 (1), R01HL063082 (1), R21AA019994 (1), R21DA033597 (1), U01DK046472 (1)