18 completed, 11 active not recruiting, 10 recruiting, 6 terminated. 55 Phase 2, 11 Phase 1, 2 Phase 3.
Follow Stereotactic Radiosurgery: new trials by email Literature Review of Stereotactic Radiosurgery trials Research Report on Stereotactic Radiosurgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery to Improve Treatment of Melanoma Brain Metastases Emavusertib, Pembrolizumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 / Phase 2 | Suspended | Mayo Clinic | 23 | 2026-11-30 | 2026-10-20 |
| A Study of Ivonescimab, Chemotherapy, and Stereotactic Radiosurgery for People With Non-Small Cell Lung Cancer Ivonescimab, Stereotactic Radiosurgery - Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 53 | 2026-04-10 | 2026-04-17 |
| Osimertinib Plus Stereotactic Radiosurgery/Radiotherapy for EGFR-Mutant Non-Small Cell Lung Cancer With Symptomatic Brain Metastases Osimertinib, Stereotactic Radiosurgery - Non-Small Cell Lung Cancer, Brain Metastases From Non-small Cell Lung Cancer (NSCLC) | Phase 2 | Recruiting | Cho Ray Hospital | 41 | 2026-02-27 | 2026-11-02 |
| EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active Systemic Therapy, Stereotactic Radiosurgery - Brain Metastases | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 316 | 2025-02-14 | 2026-10-06 |
| Stereotactic Radiosurgery in the Treatment of Essential Tremor Stereotactic Radiosurgery - Essential Tremor | Phase 2 | Recruiting | Maria Sklodowska-Curie National Research Institute of Oncology | 42 | 2024-12-16 | 2026-10-20 |
| Risk Adapted Spinal Cord/Cauda Constraint Relaxation for High-risk Patients With Metastatic Epidural Spinal Cord Compression Undergoing Spine Stereotactic Radiosurgery Stereotactic Radiosurgery - Spinal Cord, Metastatic Epidural | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 60 | 2024-11-11 | 2026-10-06 |
| Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases Adagrasib, Stereotactic Radiosurgery - Non Small Cell Lung Cancer, NSCLC | Phase 2 | Recruiting | Ryan Gentzler, MD | 30 | 2024-08-06 | 2026-04-08 |
| Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements Alectinib, Stereotactic Radiosurgery - Lung Cancer, NSCLC | Phase 1 / Phase 2 | Recruiting | Joshua Palmer | 56 | 2024-03-07 | 2026-04-08 |
| Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases Azeliragon, Stereotactic radiosurgery, Corticosteroid - Cancer, Metastasis | Phase 1 / Phase 2 | Suspended | Baptist Health South Florida | 46 | 2023-11-17 | 2026-06-16 |
| Frameless Stereotactic Radiosurgery for Intact Brain Metastases Stereotactic Radiosurgery - Brain Metastases | Phase 2 | Recruiting | University of Chicago | 166 | 2023-09-05 | 2026-09-14 |
| SRS Timing With Immune Checkpoint Inhibition in Patients With Untreated Brain Metastases From Non-small Cell Lung Cancer Stereotactic Radiosurgery, Immunotherapy - Brain Metastases, Non Small Cell Lung Cancer | Phase 2 | Withdrawn | Duke University | 2023-03-01 | 2023-03-02 | |
| A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain Stereotactic Radiosurgery, Cerebrospinal fluid collection - Lung Cancer, Lung Cancer Metastatic | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 62 | 2022-06-10 | 2026-06-10 |
| Hippocampal-Sparing Stereotactic Radiosurgery Treatment of Brain Metastases Using CyberKnife Hippocampal-sparing, Stereotactic radiosurgery - Brain Metastases, Radiosurgery | Phase 2 | Unknown | Ottawa Hospital Research Institute | 70 | 2022-04-01 | 2022-02-16 |
| SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial Questionnaire Administration, Stereotactic Radiosurgery, Magnetic Resonance Imaging - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm | Phase 2 | Recruiting | Mayo Clinic | 90 | 2022-03-14 | 2026-10-01 |
| Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therapy in Subjects With Breast Cancer Brain Metastases Olaparib, Stereotactic Radiosurgery, Durvalumab - Breast Cancer, Brain Metastases, Adult | Phase 1 / Phase 2 | Active not recruiting | Colette Shen | 41 | 2022-03-09 | 2026-07-10 |
| Stereotactic Radiosurgery and Immunotherapy (Pembrolizumab) for the Treatment of Recurrent Meningioma Pembrolizumab, Stereotactic Radiosurgery - Grade I Meningioma, Adult, Grade II Meningioma, Adult | Phase 2 | Active not recruiting | Nancy Ann Oberheim Bush, MD | 35 | 2021-03-25 | 2026-04-15 |
| Stereotactic Radiosurgery for the Treatment of Patients With Small Cell Lung Cancer Brain Metastasis Questionnaire Administration, Stereotactic Radiosurgery - Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 55 | 2020-08-28 | 2026-09-14 |
| Anti-GITR/Anti-PD1/Stereotactic Radiosurgery, in Recurrent Glioblastoma INCMGA00012, INCAGN01876, SRS - Glioblastoma | Phase 2 | Active not recruiting | University of Pennsylvania | 39 | 2020-06-23 | 2026-06-23 |
| Stereotactic Radiosurgery Combination With Anlotinib for Limited Brain Metastases With Perilesional Edema in NSCLC Anlotinib, Stereotactic Radiosurgery - Stereotactic Body Radiation Therapy | Phase 2 | Unknown | Peking University Third Hospital | 50 | 2019-12-24 | 2020-03-04 |
| Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma Biospecimen Collection, Echocardiography Test, Ipilimumab - Grade 2 Meningioma, Grade 3 Meningioma | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 38 | 2019-06-17 | 2026-07-31 |
Showing 20 of 55. Sign in to see all of them.
Brain Neoplasms (27) · Melanoma (11) · Neoplasm Metastasis (11) · Carcinoma, Non-Small-Cell Lung (9) · Lung Neoplasms (7) · Breast Neoplasms (5) · Sarcoma (4) · Glioblastoma (3) · Neoplasms (3) · Small Cell Lung Carcinoma (3) · Carcinoma, Renal Cell (2) · Central Nervous System Neoplasms (2) · Colonic Neoplasms (2) · Gliosarcoma (2) · Meningioma (2)
M.D. Anderson Cancer Center (7) · Case Comprehensive Cancer Center (4) · Memorial Sloan Kettering Cancer Center (3) · National Cancer Institute (NCI) (3) · Duke University (2) · Mayo Clinic (2) · Radiation Therapy Oncology Group (2) · Stanford University (2) · Accuray Incorporated (1) · Baptist Health South Florida (1) · Cho Ray Hospital (1) · Colette Shen (1) · David A. Clump, MD, PhD (1) · Eastern Cooperative Oncology Group (1) · Heath Skinner (1)
United States (46) · Canada (4) · China (2) · Israel (2) · South Korea (2) · Australia (1) · France (1) · Germany (1) · Peru (1) · Poland (1) · Puerto Rico (1) · Saudi Arabia (1) · Vietnam (1)
Jing Li (4) · David A Clump, MD (2) · Alain Algazi, MD (1) · Aleksandra Napieralska (1) · Amol Ghia, MD (1) · Amol J Ghia (1) · Andrew A Kanner, MD (1) · Bently Doonan, MD, MS (1) · Christopher Lao, M.D. (1) · Colette Shen, M.D., Ph.D (1) · Danny Y. Song, MD (1) · Dennise Carter, MD (1) · Donald C. Shina, MD (1) · Douglas Einstein, MD, PhD (1)
PMID 16314647, PMID 16575331, PMID 16723887, PMID 16750317, PMID 17257702, PMID 22445005, PMID 24890347, PMID 25680594, PMID 27223498, PMID 32483359, PMID 33294918, PMID 35602670, PMID 37079324, PMID 37268724, PMID 37506981
P30CA016672 (2), P30CA043703 (2), U10CA180868 (2), N01CM00039 (1), P30CA014236 (1), P30CA015704 (1), P30CA016059 (1), P30CA072720 (1), U01CA062461 (1), U01CA069852 (1), U01CA076576 (1), U10CA021661 (1), U10CA032102 (1), UM1CA186689 (1), UM1CA186704 (1)