8 active not recruiting, 7 completed, 5 terminated, 3 recruiting. 26 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 26 | Active not recruiting 8, Completed 7, Terminated 5, Recruiting 3, Unknown 2, Withdrawn 1 |
| Phase 2 | 2 | Completed 2 |
Follow Stereotactic Radiosurgery: new trials by email Literature Review of Stereotactic Radiosurgery trials Research Report on Stereotactic Radiosurgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adding Surgery and Radiation to the Usual Treatment for HER2-Positive Breast Cancer That Had Already Spread at Diagnosis Biopsy Procedure, Biospecimen Collection, Breast Conservation Treatment - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Positive Breast Carcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 562 | 2027-03-09 | 2026-10-13 |
| Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain Computed Tomography, Fractionated Stereotactic Radiation Therapy, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 3 | Active not recruiting | NRG Oncology | 274 | 2024-12-12 | 2026-09-14 |
| Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer Stereotactic radiosurgery, Immune checkpoint inhibitor - Non-Small Cell Lung Cancer, Melanoma | Phase 3 | Recruiting | ETOP IBCSG Partners Foundation | 180 | 2022-11-30 | 2026-04-27 |
| Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases Brain Surgery, Quality-of-Life Assessment, Questionnaire Administration - Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | NRG Oncology | 237 | 2022-10-24 | 2026-09-10 |
| Pre- Versus Post-operative SRS for Resectable Brain Metastases Brain Surgery, Stereotactic Radiosurgery - Brain Metastases | Phase 3 | Terminated | AHS Cancer Control Alberta | 8 | 2021-09-27 | 2025-07-18 |
| Stereotactic Radiosurgery vs Whole Brain Radiotherapy in Breast Cancer With Brain Oligometastasis Stereotactic Radiosurgery - Breast Cancer, Brain Metastases, Adult | Phase 3 | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 98 | 2021-08-31 | 2023-10-17 |
| Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Lung Non-Small Cell Carcinoma | Phase 3 | Terminated | NRG Oncology | 19 | 2021-08-05 | 2026-05-20 |
| Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability Biospecimen Collection, Magnetic Resonance Imaging, Memantine Hydrochloride - Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | NRG Oncology | 152 | 2021-06-08 | 2026-09-14 |
| Single Fraction Stereotactic Radiosurgery or Three to Five Fraction Stereotactic Radiosurgery in Treating Patients With Brain Metastasis That Has Been Removed by Surgery Single Fraction Stereotactic Radiosurgery, Fractionated Stereotactic Radiosurgery, Quality-of-Life Assessment - Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | Alliance for Clinical Trials in Oncology | 242 | 2019-11-19 | 2026-09-17 |
| Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors Conventional Surgery, Questionnaire Administration, Stereotactic Radiosurgery - Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Brain | Phase 3 | Recruiting | Mayo Clinic | 140 | 2018-11-19 | 2026-08-19 |
| Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases Quality-of-Life Assessment, Questionnaire Administration, Stereotactic Radiosurgery - Malignant Neoplasm, Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | M.D. Anderson Cancer Center | 180 | 2018-11-08 | 2026-08-10 |
| Testing Whether Treating Breast Cancer Metastases With Surgery or High-Dose Radiation Improves Survival Stereotactic Body Radiotherapy, Surgery - Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8, Metastatic Breast Carcinoma | Phase 2 / Phase 3 | Completed | NRG Oncology | 129 | 2014-12-24 | 2026-07-10 |
| Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma Cyclophosphamide, Doxorubicin, Doxorubicin Hydrochloride - Metastatic Ewing Sarcoma, Metastatic Malignant Neoplasm in the Bone | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 312 | 2014-12-12 | 2026-10-22 |
| Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain Metastases Cognitive Assessment, Quality-of-Life Assessment, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm, Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | M.D. Anderson Cancer Center | 88 | 2012-08-02 | 2026-09-16 |
| Stereotactic Radiation in Vestibular Schwannoma stereotactic radiotherapy, stereotactic radiosurgery - Vestibular Schwannoma | Phase 3 | Unknown | Ramathibodi Hospital | 200 | 2011-10-01 | 2011-10-10 |
| Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery stereotactic radiosurgery, whole-brain radiation therapy - Cognitive/Functional Effects, Metastatic Cancer | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 194 | 2011-07-01 | 2022-09-16 |
| Surgery and Whole Brain Radiotherapy (RT) Versus Whole Brain Radiotherapy (RT) and Radiosurgery for 1-3 Resectable Brain Metastases surgery, radiosurgery - Metastases, Cancer | Phase 3 | Withdrawn | Barretos Cancer Hospital | 2010-07-01 | 2014-02-04 | |
| Image-Guided Radiosurgery or Stereotactic Body Radiation Therapy in Treating Patients With Localized Spine Metastasis External beam radiation therapy, Radiosurgery/SBRT - Metastatic Cancer, Pain | Phase 2 / Phase 3 | Completed | Radiation Therapy Oncology Group | 399 | 2009-11-01 | 2025-04-29 |
| Stereotactic Radiosurgery Compared to Observation in Treating Patients With Brain Metastases Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | M.D. Anderson Cancer Center | 132 | 2009-08-13 | 2026-08-11 |
| Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases radiation therapy, stereotactic radiosurgery - Breast Cancer, Cognitive/Functional Effects | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 213 | 2006-07-01 | 2022-09-16 |
Showing 20 of 26. Sign in to see all of them.
Brain Neoplasms (18) · Neoplasm Metastasis (9) · Breast Neoplasms (5) · Carcinoma, Non-Small-Cell Lung (5) · Lung Neoplasms (4) · Melanoma (3) · Carcinoma, Renal Cell (2) · Central Nervous System Neoplasms (2) · Neoplasms (2) · Small Cell Lung Carcinoma (2) · Astrocytoma (1) · Breast Neoplasms, Male (1) · Gastrointestinal Neoplasms (1) · Glioblastoma (1) · Gliosarcoma (1)
NRG Oncology (5) · M.D. Anderson Cancer Center (4) · Alliance for Clinical Trials in Oncology (3) · European Organisation for Research and Treatment of Cancer - EORTC (3) · National Cancer Institute (NCI) (2) · Radiation Therapy Oncology Group (2) · AHS Cancer Control Alberta (1) · Barretos Cancer Hospital (1) · ETOP IBCSG Partners Foundation (1) · Mayo Clinic (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · Ramathibodi Hospital (1) · SWOG Cancer Research Network (1)
United States (18) · Canada (12) · Netherlands (4) · Switzerland (4) · Germany (3) · Spain (3) · United Kingdom (3) · France (2) · Hong Kong (2) · Israel (2) · Italy (2) · Australia (1) · Belgium (1) · Brazil (1) · Finland (1)
Paul D. Brown, MD (3) · Vinai Gondi (2) · Brigitta Baumert, MD, PhD (1) · Budhi Singh Yadav, MD (1) · David W. Andrews, MD, FACS (1) · Debra N Yeboa (1) · Debra NAna Yeboa (1) · Elizabeth Yan, M.D. (1) · Frederick F. Lang, M.D. (1) · Jing Li (1) · John G. Wolbers, MD, PhD (1) · Luis Souhami, MD (1) · Mariya Rozenblit (1) · Michael Weller, MD (1) · Paul Sperduto (1)
PMID 10549493, PMID 15158627, PMID 16062084, PMID 18455252, PMID 21041710, PMID 21584645, PMID 23213105, PMID 24890347, PMID 27458945, PMID 28687375, PMID 28687377, PMID 28939223, PMID 28961826, PMID 30419088, PMID 35602670, PMID 36264568, PMID 36472389, PMID 36585629, PMID 36669140, PMID 37079324, PMID 37289451, PMID 37717787, PMID 38475765, PMID 40531511, PMID 40983872, PMID 42208702
U10CA180868 (4), P30CA016672 (1), U10CA021661 (1), U10CA098543 (1), U10CA180821 (1), U10CA180886 (1), U10CA180888 (1), UG1CA189867 (1)