56 completed, 24 active not recruiting, 23 terminated, 21 recruiting. 55 Phase 2, 38 Phase 1, 36 Not applicable, 26 Phase 3, 4 Early Phase 1.
Follow Stereotactic Radiosurgery: new trials by email Literature Review of Stereotactic Radiosurgery trials Research Report on Stereotactic Radiosurgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adding Surgery and Radiation to the Usual Treatment for HER2-Positive Breast Cancer That Had Already Spread at Diagnosis Biopsy Procedure, Biospecimen Collection, Breast Conservation Treatment - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Positive Breast Carcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 562 | 2027-03-09 | 2026-10-13 |
| Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases Trastuzumab Deruxtecan, Stereotactic Radiosurgery - Breast Cancer, HER2-positive Breast Cancer | Phase 1 | Not yet recruiting | Baptist Health South Florida | 20 | 2027-01-01 | 2026-10-01 |
| CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery to Improve Treatment of Melanoma Brain Metastases Emavusertib, Pembrolizumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 / Phase 2 | Suspended | Mayo Clinic | 23 | 2026-11-30 | 2026-10-20 |
| A Study of Stereotactic Radiosurgery (SRS) in People With Brain Cancer Having Tumor Resection Surgery Stereotactic Radiosurgery, Surgical Resection - Brain Metastasases | Not applicable | Recruiting | Memorial Sloan Kettering Cancer Center | 50 | 2026-08-28 | 2026-09-09 |
| A Study of Ivonescimab, Chemotherapy, and Stereotactic Radiosurgery for People With Non-Small Cell Lung Cancer Ivonescimab, Stereotactic Radiosurgery - Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 53 | 2026-04-10 | 2026-04-17 |
| Osimertinib Plus Stereotactic Radiosurgery/Radiotherapy for EGFR-Mutant Non-Small Cell Lung Cancer With Symptomatic Brain Metastases Osimertinib, Stereotactic Radiosurgery - Non-Small Cell Lung Cancer, Brain Metastases From Non-small Cell Lung Cancer (NSCLC) | Phase 2 | Recruiting | Cho Ray Hospital | 41 | 2026-02-27 | 2026-11-02 |
| EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active Systemic Therapy, Stereotactic Radiosurgery - Brain Metastases | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 316 | 2025-02-14 | 2026-10-06 |
| Hypophysectomy by Stereotactic Radiosurgery for Cancer-Related Pain Stereotactic Radiosurgery - Hypophysectomy | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 40 | 2025-01-06 | 2026-07-16 |
| Stereotactic Radiosurgery in the Treatment of Essential Tremor Stereotactic Radiosurgery - Essential Tremor | Phase 2 | Recruiting | Maria Sklodowska-Curie National Research Institute of Oncology | 42 | 2024-12-16 | 2026-10-20 |
| Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain Computed Tomography, Fractionated Stereotactic Radiation Therapy, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 3 | Active not recruiting | NRG Oncology | 274 | 2024-12-12 | 2026-09-14 |
| Risk Adapted Spinal Cord/Cauda Constraint Relaxation for High-risk Patients With Metastatic Epidural Spinal Cord Compression Undergoing Spine Stereotactic Radiosurgery Stereotactic Radiosurgery - Spinal Cord, Metastatic Epidural | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 60 | 2024-11-11 | 2026-10-06 |
| Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases Adagrasib, Stereotactic Radiosurgery - Non Small Cell Lung Cancer, NSCLC | Phase 2 | Recruiting | Ryan Gentzler, MD | 30 | 2024-08-06 | 2026-04-08 |
| Measuring and Mapping Cognitive Decline After Brain Radiosurgery Neurocognitive testing, Quality of Life questionnaire, Stereotactic radiosurgery - Brain Metastases, Meningiomas | Active not recruiting | University of Nottingham | 80 | 2024-06-21 | 2026-05-04 | |
| Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements Alectinib, Stereotactic Radiosurgery - Lung Cancer, NSCLC | Phase 1 / Phase 2 | Recruiting | Joshua Palmer | 56 | 2024-03-07 | 2026-04-08 |
| Evaluating Pre-Treatment Vestibular Physical Therapy Rehab for Patients With Vestibular Schwannomas Microsurgical resection of VS, Stereotactic radiosurgery, PREHAB - Vestibular Schwannoma | Not applicable | Recruiting | Medical College of Wisconsin | 36 | 2024-01-22 | 2026-03-24 |
| An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer Behavioral Dietary Intervention, Text Message-Based Navigation Intervention, Internet-Based Intervention - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Not applicable | Terminated | Thomas Jefferson University | 1 | 2023-12-13 | 2026-03-03 |
| Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases Azeliragon, Stereotactic radiosurgery, Corticosteroid - Cancer, Metastasis | Phase 1 / Phase 2 | Suspended | Baptist Health South Florida | 46 | 2023-11-17 | 2026-06-16 |
| Frameless Stereotactic Radiosurgery for Intact Brain Metastases Stereotactic Radiosurgery - Brain Metastases | Phase 2 | Recruiting | University of Chicago | 166 | 2023-09-05 | 2026-09-14 |
| Vertebroplasty With Radiation Therapy for Spine Metastatic Cancer Patients With Indeterminate Lesion (SINS Criteria) Immunotherapy, Stereotactic Radiosurgery, Vertebroplasty - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 200 | 2023-03-27 | 2026-04-09 |
| SRS Timing With Immune Checkpoint Inhibition in Patients With Untreated Brain Metastases From Non-small Cell Lung Cancer Stereotactic Radiosurgery, Immunotherapy - Brain Metastases, Non Small Cell Lung Cancer | Phase 2 | Withdrawn | Duke University | 2023-03-01 | 2023-03-02 |
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Brain Neoplasms (79) · Neoplasm Metastasis (30) · Carcinoma, Non-Small-Cell Lung (21) · Melanoma (17) · Breast Neoplasms (15) · Lung Neoplasms (14) · Glioblastoma (11) · Carcinoma, Renal Cell (7) · Neoplasms (7) · Central Nervous System Neoplasms (6) · Gliosarcoma (6) · Glioma (5) · Prostatic Neoplasms (5) · Small Cell Lung Carcinoma (5) · Astrocytoma (4)
M.D. Anderson Cancer Center (14) · Case Comprehensive Cancer Center (11) · National Cancer Institute (NCI) (7) · NRG Oncology (6) · Duke University (4) · Memorial Sloan Kettering Cancer Center (4) · Stanford University (4) · Alliance for Clinical Trials in Oncology (3) · Emory University (3) · European Organisation for Research and Treatment of Cancer - EORTC (3) · Mayo Clinic (3) · Radiation Therapy Oncology Group (3) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (3) · The Cooper Health System (3)
United States (124) · Canada (16) · Netherlands (6) · Switzerland (6) · Germany (5) · Italy (5) · France (4) · United Kingdom (4) · Australia (3) · Israel (3) · Spain (3) · Belgium (2) · China (2) · Hong Kong (2) · Norway (2)
Jing Li (5) · Paul D. Brown, MD (4) · David A Clump, MD (2) · Iris Catrice Gibbs (2) · Jeffrey Bradley, M.D. (2) · Lawrence Kleinberg, MD (2) · Lee E. Ponsky, MD (2) · Steven Chmura (2) · Vinai Gondi (2) · Wenyin Shi, MD, PhD (2) · Alain Algazi, MD (1) · Albert Koong (1) · Aleksandra Napieralska (1) · Alexis M Demopoulos, MD (1) · Amol Ghia, MD (1)
PMID 10549493, PMID 15158627, PMID 16062084, PMID 16314647, PMID 16575331, PMID 16723887, PMID 16750317, PMID 17257702, PMID 18455252, PMID 21041710, PMID 21584645, PMID 22217243, PMID 22445005, PMID 23211715, PMID 23213105, PMID 23332384, PMID 23522151, PMID 24621620, PMID 24890347, PMID 25680594, PMID 27223498, PMID 27458945, PMID 27871280, PMID 28273722, PMID 28687375, PMID 28687377, PMID 28743240, PMID 28939223, PMID 28961826, PMID 30211003, PMID 30370356, PMID 30419088, PMID 30825962, PMID 30948807, PMID 32483359, PMID 32642687, PMID 33294918, PMID 33308265, PMID 33333200, PMID 33744468, PMID 33885704, PMID 34604088, PMID 34806396, PMID 34926839, PMID 34934856, PMID 34934864, PMID 35195562, PMID 35315341, PMID 35602670, PMID 36264568
P30CA043703 (7), U10CA180868 (6), P30CA016672 (3), P30CA138292 (3), U10CA021661 (3), P30CA013330 (2), U01CA076576 (2), N01CM00039 (1), P30CA006973 (1), P30CA014089 (1), P30CA014236 (1), P30CA015704 (1), P30CA016059 (1), P30CA033572 (1), P30CA056036 (1)