4 completed, 3 terminated, 2 recruiting, 2 withdrawn. 5 Not applicable, 3 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 2, Terminated 2, Recruiting 1 |
| Phase 2 | 3 | Completed 1, Terminated 1, Unknown 1 |
| Phase 1 | 2 | Completed 1, Not yet recruiting 1 |
| Phase 3 | 2 | Withdrawn 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SBRT for Ultra-Central NonSmall Cell Lung Cancer SBRT - Nonsmall Cell Lung Cancer Stage | Phase 1 | Not yet recruiting | Georgetown University | 35 | 2026-11-01 | 2026-10-01 |
| MELanoma Brain Metastasis Treated With CYberknife Melanoma (Skin Cancer) | Recruiting | European Institute of Oncology | 50 | 2026-08-25 | 2026-09-10 | |
| a SIngle Center Study of Post-operative STEReotactic RAdiotherapY for Endometrial Cancer Stereotactic Post-operative Radiotherapy for Endometrial Cancer - Endometrial Cancer | Not applicable | Recruiting | ARNAS Civico Di Cristina Benfratelli Hospital | 60 | 2025-05-02 | 2025-06-25 |
| Radiosurgical Hypophysectomy for Bone Metasteses Pain radiosurgical hypophysectomy - Bone Metastases | Not applicable | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 5 | 2018-05-08 | 2026-09-17 |
| SRS and Nivolumab in Treating Patients With Newly Diagnosed Melanoma Metastases in the Brain or Spine Laboratory Biomarker Analysis, Nivolumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Neoplasm in the Spine | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 17 | 2016-06-23 | 2021-11-30 |
| Study of SIB-IMRT in Combination With 5-FU and Mitomycin-C Among Patients With Locally Advanced Anal Canal Cancer: Efficacy, Safety and Quality of Life 5Fluorouracile and Mitomycin-C, Simultaneously integrated boost of intensity modulated radiation therapy (SIB-IMRT) by tomotherapy - Locally Advanced Anal Canal Cancer | Phase 2 | Completed | Centre Francois Baclesse | 71 | 2015-12-01 | 2026-08-31 |
| Transarterial Chemoembolization vs CyberKnife for Recurrent Hepatocellular Carcinoma CyberKnife, TACE, CT Contrast - Carcinoma, Hepatocellular | Phase 3 | Withdrawn | Albert Koong | 2011-02-01 | 2012-06-11 | |
| Transarterial Chemoembolization (TACE) vs. CyberKnife for Recurrent Hepatocellular Carcinoma (HCC) Transarterial Chemoembolization, CyberKnife SBRT - Recurrent Hepatocellular Carcinoma | Phase 3 | Withdrawn | Accuray Incorporated | 2011-02-01 | 2012-02-20 | |
| CyberKnife® for Hepatic Metastases From Colorectal Cancer CyberKnife SBRT - Colorectal Liver Metastases | Phase 2 | Terminated | Accuray Incorporated | 15 | 2011-01-01 | 2013-04-08 |
| Randomized Study to Compare CyberKnife to Surgical Resection In Stage I Non-small Cell Lung Cancer CyberKnife Stereotactic Radiotherapy, Surgery - Non-small Cell Lung Cancer | Not applicable | Terminated | Accuray Incorporated | 36 | 2008-12-01 | 2020-07-14 |
| CyberKnife Radiosurgery for Organ-Confined Prostate Cancer: Homogenous Dose Distribution CyberKnife Stereotactic Radiosurgery - Prostate Cancer, Prostatic Cancer | Not applicable | Completed | Accuray Incorporated | 379 | 2007-12-01 | 2023-05-09 |
| CyberKnife Radiosurgery For Low & Intermediate Risk Prostate Cancer: Emulating HDR Brachytherapy Dosimetry CyberKnife Stereotactic Radiosurgery - Low Risk, CyberKnife Stereotactic Radiosurgery - Intermediate Risk - Prostate Cancer, Prostatic Cancer | Not applicable | Completed | Accuray Incorporated | 307 | 2007-10-22 | 2023-05-09 |
| CyberKnife Radiosurgical Treatment of Inoperable Early Stage Non-Small Cell Lung Cancer CyberKnife Stereotactic Radiosurgery - Non-small Cell Lung Cancer | Phase 2 | Unknown | Accuray Incorporated | 40 | 2006-04-01 | 2021-03-05 |
Brain Neoplasms (2) · Carcinoma, Hepatocellular (2) · Carcinoma, Non-Small-Cell Lung (2) · Melanoma (2) · Prostatic Neoplasms (2) · Colorectal Neoplasms (1) · Endometrial Neoplasms (1) · Lung Neoplasms (1)
Radiosurgery (5) · Mitomycin (2) · Cisplatin (1) · Doxorubicin (1) · Epirubicin (1) · Fluorouracil (1) · Gemcitabine (1) · Nivolumab (1) · Radiotherapy (1) · Surgical Procedures, Operative (1) · Thoracic Surgery, Video-Assisted (1)
United States (9) · France (3) · China (2) · Italy (2) · Germany (1) · Taiwan (1) · United Kingdom (1)
Albert Koong (1) · Albert Koong, MD, PhD (1) · Daniel Chang, MD (1) · Donald B Fuller, MD (1) · George Mardirossian, PhD (1) · Irving Kaplan, MD (1) · Jack Roth, M.D. (1) · James Luketich, MD (1) · Jonathan Lischalk, MD (1) · Kristin Redmond, MD (1) · Lawrence Kleinberg (1) · Martin Sanda, MD (1) · Nishita Kothary, MD (1) · Robert Meier, MD (1)
PMID 23582248, PMID 25981812, PMID 30071295, PMID 30191864, PMID 33668061, PMID 35420695