18 completed, 6 active not recruiting, 5 terminated, 4 recruiting. 38 Phase 1, 11 Phase 2.
Follow Stereotactic Radiosurgery: new trials by email Literature Review of Stereotactic Radiosurgery trials Research Report on Stereotactic Radiosurgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases Trastuzumab Deruxtecan, Stereotactic Radiosurgery - Breast Cancer, HER2-positive Breast Cancer | Phase 1 | Not yet recruiting | Baptist Health South Florida | 20 | 2027-01-01 | 2026-10-01 |
| CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery to Improve Treatment of Melanoma Brain Metastases Emavusertib, Pembrolizumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 / Phase 2 | Suspended | Mayo Clinic | 23 | 2026-11-30 | 2026-10-20 |
| A Study of Ivonescimab, Chemotherapy, and Stereotactic Radiosurgery for People With Non-Small Cell Lung Cancer Ivonescimab, Stereotactic Radiosurgery - Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 53 | 2026-04-10 | 2026-04-17 |
| Hypophysectomy by Stereotactic Radiosurgery for Cancer-Related Pain Stereotactic Radiosurgery - Hypophysectomy | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 40 | 2025-01-06 | 2026-07-16 |
| Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements Alectinib, Stereotactic Radiosurgery - Lung Cancer, NSCLC | Phase 1 / Phase 2 | Recruiting | Joshua Palmer | 56 | 2024-03-07 | 2026-04-08 |
| Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases Azeliragon, Stereotactic radiosurgery, Corticosteroid - Cancer, Metastasis | Phase 1 / Phase 2 | Suspended | Baptist Health South Florida | 46 | 2023-11-17 | 2026-06-16 |
| Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases Ipilimumab, Nivolumab, Pembrolizumab - Clinical Stage IV Cutaneous Melanoma AJCC v8, Melanoma of Unknown Primary | Phase 1 | Terminated | Emory University | 1 | 2022-10-13 | 2026-04-23 |
| Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therapy in Subjects With Breast Cancer Brain Metastases Olaparib, Stereotactic Radiosurgery, Durvalumab - Breast Cancer, Brain Metastases, Adult | Phase 1 / Phase 2 | Active not recruiting | Colette Shen | 41 | 2022-03-09 | 2026-07-10 |
| Sulfasalazine and Stereotactic Radiosurgery for Recurrent Glioblastoma Sulfasalazine - Glioma, Glioblastoma | Phase 1 | Completed | Haukeland University Hospital | 24 | 2020-03-01 | 2023-03-03 |
| Trial of Anti-Tim-3 in Combination With Anti-PD-1 and SRS in Recurrent GBM MBG453 - Glioblastoma Multiforme | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 16 | 2020-02-18 | 2026-10-07 |
| Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma Biospecimen Collection, Echocardiography Test, Ipilimumab - Grade 2 Meningioma, Grade 3 Meningioma | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 38 | 2019-06-17 | 2026-07-31 |
| Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases Nivolumab, Stereotactic Radiosurgery - Metastatic Breast Cancer, Brain Metastases | Phase 1 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 14 | 2019-01-30 | 2025-12-04 |
| Stereotactic Body Radiation Therapy, Tremelimumab and Durvalumab in Treating Participants With Recurrent or Metastatic Cervical, Vaginal, or Vulvar Cancers Durvalumab, Laboratory Biomarker Analysis, Stereotactic Radiosurgery - Advanced Cervical Adenocarcinoma, Advanced Vaginal Carcinoma | Phase 1 | Completed | M.D. Anderson Cancer Center | 20 | 2018-07-18 | 2023-09-13 |
| Neurocognitive Decline in Patients With Brain Metastases Stereotactic Radiosurgery - Brain Metastases | Phase 1 / Phase 2 | Active not recruiting | University of Texas Southwestern Medical Center | 80 | 2017-12-05 | 2026-09-18 |
| Nivolumab With or Without Stereotactic Radiosurgery in Treating Patients With Recurrent, Advanced, or Metastatic Chordoma Laboratory Biomarker Analysis, Nivolumab, Stereotactic Radiosurgery - Chordoma | Phase 1 | Active not recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 21 | 2017-03-10 | 2026-01-06 |
| Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer Cognitive Assessment, Ipilimumab, Laboratory Biomarker Analysis - Metastatic Malignant Neoplasm in the Brain, Stage IV Non-Small Cell Lung Cancer AJCC v7 | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 80 | 2016-12-16 | 2026-05-20 |
| Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases Pembrolizumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 | Completed | Emory University | 25 | 2016-10-04 | 2026-03-09 |
| SRS and Nivolumab in Treating Patients With Newly Diagnosed Melanoma Metastases in the Brain or Spine Laboratory Biomarker Analysis, Nivolumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Neoplasm in the Spine | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 17 | 2016-06-23 | 2021-11-30 |
| Stereotactic Radiosurgery With Nivolumab and Valproate in Patients With Recurrent Glioblastoma Stereotactic Radiosurgery, Nivolumab, Valproate - Glioblastoma | Phase 1 | Terminated | University of Virginia | 4 | 2016-05-24 | 2017-05-31 |
| Stereotactic Radiosurgery Dose Escalation for Brain Metastases Stereotactic Radiosurgery - Brain Metastases | Phase 1 | Recruiting | University of Utah | 86 | 2015-05-07 | 2026-07-02 |
Showing 20 of 38. Sign in to see all of them.
Brain Neoplasms (22) · Breast Neoplasms (6) · Carcinoma, Non-Small-Cell Lung (6) · Glioblastoma (6) · Melanoma (5) · Neoplasm Metastasis (5) · Glioma (4) · Gliosarcoma (3) · Lung Neoplasms (3) · Neoplasms (3) · Astrocytoma (2) · Breast Neoplasms, Male (2) · Meningioma (2) · Oligodendroglioma (2) · Uveal Melanoma (2)
M.D. Anderson Cancer Center (4) · National Cancer Institute (NCI) (4) · Stanford University (4) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · Baptist Health South Florida (2) · Case Comprehensive Cancer Center (2) · Emory University (2) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (2) · University of Texas Southwestern Medical Center (2) · Centre Antoine Lacassagne (1) · City of Hope Medical Center (1) · Colette Shen (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Haukeland University Hospital (1) · Joshua Palmer (1)
United States (36) · Canada (1) · France (1) · Norway (1) · Switzerland (1)
Iris Catrice Gibbs (2) · Lawrence Kleinberg, MD (2) · Wenyin Shi, MD, PhD (2) · Albert Koong (1) · Amol J. Ghia, MD (1) · Anuradha Chakravarthy (1) · Benjamin Purow, MD (1) · Bente S Skeie (1) · Bently Doonan, MD, MS (1) · Chenyang Wang, MD (1) · Colette Shen, M.D., Ph.D (1) · James L. Rubenstein, MD, PhD (1) · Jana Portnow, MD (1) · Jiayi Huang (1)
PMID 16575331, PMID 16723887, PMID 17257702, PMID 23332384, PMID 30825962, PMID 33744468, PMID 33885704, PMID 34934864, PMID 35315341, PMID 40295143, PMID 42229231
P30CA138292 (2), U01CA076576 (2), N01CM00039 (1), P30CA006973 (1), P30CA016672 (1), P30CA033572 (1), P30CA043703 (1), P30CA056036 (1), U01CA062461 (1), U01CA069852 (1), U10CA021661 (1), U10CA180868 (1), UM1CA186689 (1), UM1CA186704 (1)