20 completed, 5 unknown, 2 active not recruiting, 2 not yet recruiting. 34 Phase 3, 9 Phase 2.
Follow Sodium Bicarbonate: new trials by email Literature Review of Sodium Bicarbonate trials Research Report on Sodium Bicarbonate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes Sodium Bicarbonate (NaHCO3), Warmed lignocaine, Hyaluronidase Injection - Dermatochalasis of Upper Eyelid, Blepharoplasty | Phase 3 | Not yet recruiting | Prince of Wales Hospital, Shatin, Hong Kong | 80 | 2026-08-01 | 2026-08-03 |
| Acute Sodium Bicarbonate Supplementation in Female Basketball Players Sodium Bicarbonate (NaHCO3), Placebo - Supplementation, Sports | Phase 3 | Recruiting | Krzysztof Durkalec-Michalski | 100 | 2026-03-01 | 2026-07-28 |
| Sodium Bicarbonate in Intra-dialytic Hypertension in Chronic Hemodialysis Patients Sodium Bicarbonate (NaHCO3), Placebo - Hypertension in Dialysis Patients | Phase 2 / Phase 3 | Not yet recruiting | Assaf-Harofeh Medical Center | 40 | 2025-11-10 | 2025-11-17 |
| Efficacy and Safety of Sodium Hyaluronate Gel Combined With Sodium Bicarbonate Versus Sodium Bicarbonate Alone in Prevention of Failed Back Surgery Syndrome Sodium hyaluronate jell, Sodium Bicarbonate, Saline - Postdiscectomy Epidural Fibrosis, Pain | Phase 2 / Phase 3 | Active not recruiting | Misr University for Science and Technology | 60 | 2025-06-20 | 2025-07-29 |
| SODium BICarbonate for Metabolic Acidosis in the ICU Sodium bicarbonate, 5% Dextrose - Metabolic Acidosis, Shock | Phase 3 | Active not recruiting | Australian and New Zealand Intensive Care Research Centre | 500 | 2023-04-26 | 2026-03-27 |
| SAINT: Safe Induction of Labor Trial Buscopan 20 MG/ML Injectable Solution, Sodium bicarbonate, Placebo - Labor Complication, Induced; Birth | Phase 3 | Recruiting | Oslo University Hospital | 3000 | 2023-01-03 | 2024-04-04 |
| Quick Epidural Top-up With Alkalinized Lidocaine for Emergent Caesarean Delivery Lidocaine epinephrine buffered with sodium bicarbonate, Lidocaine epinephrine - Obstetric Labor Complications | Phase 2 / Phase 3 | Completed | University Hospital, Bordeaux | 65 | 2022-07-14 | 2026-07-31 |
| Bicarbonate Epidural Injection in Emergency Caesarian 2% adrenaline lidocaine associated with 4.2% sodium bicarbonate, 2% adrenaline lidocaine - Emergency Caesarean | Phase 3 | Completed | CHU de Reims | 400 | 2020-06-22 | 2021-03-01 |
| Injection Site Pain Botulinum Toxin Reconstituted in NS With and Without Sodium Bicarbonate Sodium Bicarbonate, Normal Saline - Wrinkle | Phase 3 | Completed | King Abdulaziz Medical City | 30 | 2019-11-09 | 2020-10-08 |
| Study of the Efficacy and Safety of Quiklean® and Klean-Prep With Dulcolax® for the Bowel Preparation Prior to Colonoscopy Quiklean® (sodium phosphate monobasic monohydrate, USP, and sodium phosphate dibasic anhydrous, USP), Polyethylene glycol 3350, sodium sulfate anhydrous, sodium bicarbonate, sodium chloride, potassium chloride, aspartame;Bisacodyl - Bowel Preparation | Phase 3 | Completed | Universal Integrated Corp. | 472 | 2019-06-10 | 2020-03-30 |
| Tumescent Antibiotic Delivery for Prevention of Surgical Site Infection Concomitant Tumescent Antibiotic Delivery & IV Delivery, Subcutaneous Tumescent Infiltration, cecefazolin and metronidazole (in a dilute solution of tumescent lidocaine, epinephrin and sodium bicarbonate in 0.9% physiologic saline) - Surgical Site Infections, Venous Thromboembolism | Phase 2 / Phase 3 | Unknown | Klein, Jeffrey A., M.D. | 400 | 2015-10-01 | 2015-07-21 |
| The BASE Study: Bicarbonate Administration to Stabilize Estimated Glomerular Filtration Rate (eGFR) Lower Dose Sodium Bicarbonate, Higher Dose Sodium Bicarbonate, Placebo - Chronic Kidney Disease | Phase 3 | Completed | Jennifer Gassman, PhD | 194 | 2015-10-01 | 2020-10-20 |
| Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill Sodium Bicarbonate - Metabolic Acidosis | Phase 3 | Completed | University Hospital, Montpellier | 400 | 2015-05-05 | 2026-06-15 |
| PrevenTion of Contrast-inducEd nephroAThy With urinE Alkalinization isotonic saline, i.v. sodium bicarbonate, oral sodium bicarbonate - Acute Kidney Injury, Contrast Media Reaction | Phase 3 | Completed | G. d'Annunzio University | 240 | 2015-03-01 | 2022-05-23 |
| Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block sodium bicarbonate, Lidocaine, sterile distilled water - Local Anesthesia | Phase 3 | Completed | Masoud Saatchi | 100 | 2014-12-01 | 2016-04-05 |
| Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis 2% lidocaine with 1:80,000 epinephrine, sodium bicarbonate, placebo - Local Anesthesia | Phase 3 | Completed | Masoud Saatchi | 80 | 2013-02-01 | 2016-08-31 |
| Alkali Therapy in Chronic Kidney Disease Sodium bicarbonate, Placebo - Chronic Kidney Disease, Metabolic Acidosis | Phase 2 / Phase 3 | Completed | Albert Einstein College of Medicine | 149 | 2011-10-01 | 2020-01-07 |
| Efficacy and Safety Clinical Trial of the Combination of Acetylsalicylic Acid, Sodium Bicarbonate and Citric Acid, Produced by Geolab Pharmaceutical Industries Ltd., Compared to Acetylsalicylic Acid (Aspirin ® - Bayer) in Patients With Episodic Tension-type Headache. Association: acetylsalicylic acid (500mg), sodium bicarbonate (1625) and citric acid (965), Aspirin - Bayer - Treatment of Episodic Tension Headache | Phase 2 / Phase 3 | Unknown | Azidus Brasil | 152 | 2011-02-01 | 2011-01-28 |
| Safety and Efficacy Study of CitraFleet (Sodium Picosulphate) as an Evacuating Treatment Prior to Colonoscopy. Sodium picosulphate, light magnesium oxide and anhydride citric acid., Polyethylene glycol, KCl, NaCl, sodium sulphate anhydrous and sodium bicarbonate. - Subjects Undergoing a Complete Exploratory Diagnostic Colonoscopy for the First Time. | Phase 3 | Completed | Laboratorios Casen-Fleet S.L.U. | 547 | 2010-01-01 | 2011-04-15 |
| Evaluation of Sodium Bicarbonate to Reduce the Incidence of Contrast Induced Chronic Kidney Injury in Patients With Kidney Disease sodium bicarbonate - Contrast Induced Kidney Injury. | Phase 3 | Terminated | MD Scientific | 391 | 2010-01-01 | 2012-08-23 |
Showing 20 of 34. Sign in to see all of them.
Renal Insufficiency, Chronic (6) · Acidosis (4) · Acute Kidney Injury (4) · Kidney Diseases (2) · Obstetric Labor Complications (2) · Pain (2) · Shock (2) · Constipation (1) · Cutis Laxa (1) · Failed Back Surgery Syndrome (1) · Gastroesophageal Reflux (1) · Infections (1) · Irritable Bowel Syndrome (1) · Renal Insufficiency (1) · Surgical Wound Infection (1)
Albert Einstein College of Medicine (2) · Bayer (2) · Masoud Saatchi (2) · Assaf-Harofeh Medical Center (1) · Austin Health (1) · Australian and New Zealand Intensive Care Research Centre (1) · Azidus Brasil (1) · CHU de Reims (1) · Clinica Mediterranea (1) · Eurofarma Laboratorios S.A. (1) · G. d'Annunzio University (1) · Hospital Sao Lucas da PUCRS (1) · Instituto Nacional de Cardiologia Ignacio Chavez (1) · Jennifer Gassman, PhD (1) · Kaiser Permanente (1)
United States (5) · Brazil (4) · France (4) · Italy (3) · Australia (2) · Canada (2) · Germany (2) · Iran (2) · Japan (2) · Poland (2) · Saudi Arabia (2) · Czechia (1) · Egypt (1) · Hong Kong (1) · India (1)
Thomas Hostetter, MD (2) · Ahmad Iaminisharif, M.D. (1) · Ahsan Alam, MD (1) · Akbar Fotuhi, M.D. (1) · Ali Vasheghani-Farahani, M.D. (1) · Alireza Amirzadegan, M.D. (1) · Amir Hossein Razavi, M.D. (1) · Anson Chun Long Wu (1) · Ary Serpa Neto, PhD (1) · Benoit de Varennes, MD (1) · Carlo Briguori, MD, PhD (1) · Daisuke Hachinohe, MD (1) · Ebrahim Kassaian, M.D. (1) · Emma Miranda Malpica, PhD (1)
PMID 12010907, PMID 15150204, PMID 18768415, PMID 21518686, PMID 21816077, PMID 21844075, PMID 23062413, PMID 23349296, PMID 23393105, PMID 23610561, PMID 26301645, PMID 26333343, PMID 2643041, PMID 29910040, PMID 31699517, PMID 34028701, PMID 34543256, PMID 34784301, PMID 35620986, PMID 38170601, PMID 40032397, PMID 40487345, PMID 42283370
R01DK087783 (1), U01DK099877 (1)