18 completed, 3 terminated, 3 unknown, 2 not yet recruiting. 32 Phase 2, 9 Phase 3, 3 Phase 1.
Follow Sodium Bicarbonate: new trials by email Literature Review of Sodium Bicarbonate trials Research Report on Sodium Bicarbonate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones Potassium Citrate, Sodium Bicarbonate - Kidney Stones, Urolithiasis, Hypocitraturia, Nephrolithiasis | Phase 1 / Phase 2 | Not yet recruiting | University of California, Los Angeles | 30 | 2026-02-01 | 2026-02-12 |
| The Effect of Sodium Bicarbonate (Nephrotrans®) on Calcification Propensity of Serum in Kidney Transplant Recipients Low dose sodium bicarbonate, High dose sodium bicarbonate - Kidney Transplant; Complications | Phase 2 | Withdrawn | Prim. Priv. Doz. Dr. Daniel Cejka | 2025-12-31 | 2026-04-27 | |
| Sodium Bicarbonate in Intra-dialytic Hypertension in Chronic Hemodialysis Patients Sodium Bicarbonate (NaHCO3), Placebo - Hypertension in Dialysis Patients | Phase 2 / Phase 3 | Not yet recruiting | Assaf-Harofeh Medical Center | 40 | 2025-11-10 | 2025-11-17 |
| Efficacy and Safety of Sodium Hyaluronate Gel Combined With Sodium Bicarbonate Versus Sodium Bicarbonate Alone in Prevention of Failed Back Surgery Syndrome Sodium hyaluronate jell, Sodium Bicarbonate, Saline - Postdiscectomy Epidural Fibrosis, Pain | Phase 2 / Phase 3 | Active not recruiting | Misr University for Science and Technology | 60 | 2025-06-20 | 2025-07-29 |
| Buffered Lidocaine for Reducing Pain in Patients Undergoing Prostate Biopsy, BURN Trial Buffered Lidocaine (1% Lidocaine + 8.4% Sodium Bicarbonate, in a 3:1 ratio), Lidocaine, Biopsy of Prostate - Prostate Cancer | Phase 1 / Phase 2 | Completed | University of Washington | 350 | 2025-01-09 | 2026-02-17 |
| Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD Sodium bicarbonate, placebo - Chronic Kidney Diseases, Metabolic Acidosis | Phase 2 | Recruiting | University of California, Davis | 80 | 2023-09-08 | 2026-05-06 |
| Atorvastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease Atorvastatin 20 Mg Oral Tablet, Sodium Bicarbonate 600 Mg Oral Tablet - Autosomal Dominant Polycystic Kidney Disease, Chronic Kidney Diseases | Phase 2 | Enrolling by invitation | Taipei Medical University Shuang Ho Hospital | 30 | 2023-05-01 | 2023-05-23 |
| Neurovascular Regulation During Exercise in Humans With Chronic Kidney Disease: Sympatholysis in CKD Sodium Bicarbonate, Exercise Training, Placebo - Chronic Kidney Disease | Phase 2 | Recruiting | Emory University | 156 | 2022-11-11 | 2026-10-30 |
| Quick Epidural Top-up With Alkalinized Lidocaine for Emergent Caesarean Delivery Lidocaine epinephrine buffered with sodium bicarbonate, Lidocaine epinephrine - Obstetric Labor Complications | Phase 2 / Phase 3 | Completed | University Hospital, Bordeaux | 65 | 2022-07-14 | 2026-07-31 |
| Study of Sodium Bicarbonate in Restoring Blocked Catheters Sodium Bicarbonate 8.4% Solution for Injection, Alteplase Injectable Solution - Cancer, Central Venous Catheterization | Phase 2 | Withdrawn | University Health Network, Toronto | 2020-06-01 | 2020-09-16 | |
| Lidocaine as an Endotracheal Tube (ETT) Cuff Media 1.8% lidocaine plus 0.76% sodium bicarbonate, Air - Cardiac Disease | Phase 2 | Completed | Mayo Clinic | 32 | 2018-07-27 | 2019-09-27 |
| Painless Local Anaesthesia With Bicarbonate Admixture Lidocaine and sodium bicarbonate, Lidocaine, Sodium cloride 0.9% - Local Infiltration, Anesthesia | Phase 2 | Completed | University of Zurich | 48 | 2017-08-01 | 2017-12-21 |
| Tumescent Antibiotic Delivery for Prevention of Surgical Site Infection Concomitant Tumescent Antibiotic Delivery & IV Delivery, Subcutaneous Tumescent Infiltration, cecefazolin and metronidazole (in a dilute solution of tumescent lidocaine, epinephrin and sodium bicarbonate in 0.9% physiologic saline) - Surgical Site Infections, Venous Thromboembolism | Phase 2 / Phase 3 | Unknown | Klein, Jeffrey A., M.D. | 400 | 2015-10-01 | 2015-07-21 |
| Bicarbonate in Patients With Out-of-hospital Cardiac Arrest Sodium bicarbonate, Normal saline - Cardiac Arrest, Metabolic Acidosis | Phase 2 | Completed | Asan Medical Center | 50 | 2014-10-01 | 2022-03-25 |
| To Evaluate Efficacy and Tolerability of Sodium Bicarbonate Toothpaste and Its Effect on Opportunistic or Resistant Organisms Sodium bicarbonate and sodium fluoride, Sodium fluoride - Oral Hygiene | Phase 2 | Completed | GlaxoSmithKline | 246 | 2014-08-25 | 2018-07-31 |
| To Evaluate the Efficacy and Tolerability of Sodium Bicarbonate Toothpaste Sodium bicarbonate plus sodium fluoride, Sodium fluoride - Oral Hygiene | Phase 2 | Completed | GlaxoSmithKline | 247 | 2014-08-01 | 2017-04-13 |
| The Effect of Nebulization of Alkaline Solution on Treating XDRAB Pneumonia With C/S Plus Minocycline C/S plus minocycline., nebulization with pH 7.4 solution, nebulization with pH 7.8 solution - Pneumonia | Phase 1 / Phase 2 | Unknown | Xijing Hospital | 90 | 2014-03-01 | 2014-02-11 |
| Sodium Bicarbonate to Prevent Acute Kidney Injury in Children Undergoing Cardiac Surgery Sodium Bicarbonate, Sodium Chloride - Acute Kidney Injury, Congenital Heart Disease | Phase 2 | Terminated | Northwell Health | 51 | 2013-09-01 | 2022-11-02 |
| Alkali Therapy in Chronic Kidney Disease Sodium bicarbonate, Placebo - Chronic Kidney Disease, Metabolic Acidosis | Phase 2 / Phase 3 | Completed | Albert Einstein College of Medicine | 149 | 2011-10-01 | 2020-01-07 |
| Efficacy and Safety Clinical Trial of the Combination of Acetylsalicylic Acid, Sodium Bicarbonate and Citric Acid, Produced by Geolab Pharmaceutical Industries Ltd., Compared to Acetylsalicylic Acid (Aspirin ® - Bayer) in Patients With Episodic Tension-type Headache. Association: acetylsalicylic acid (500mg), sodium bicarbonate (1625) and citric acid (965), Aspirin - Bayer - Treatment of Episodic Tension Headache | Phase 2 / Phase 3 | Unknown | Azidus Brasil | 152 | 2011-02-01 | 2011-01-28 |
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Renal Insufficiency, Chronic (5) · Acidosis (4) · Acute Kidney Injury (4) · Kidney Diseases (2) · Neoplasms (2) · Calculi (1) · Diabetes Mellitus (1) · Failed Back Surgery Syndrome (1) · Fatigue (1) · Heart Arrest (1) · Heart Defects, Congenital (1) · Heart Diseases (1) · Infections (1) · Insulin Resistance (1) · Kidney Calculi (1)
Austin Health (4) · Albert Einstein College of Medicine (2) · GlaxoSmithKline (2) · Asan Medical Center (1) · Assaf-Harofeh Medical Center (1) · Azidus Brasil (1) · Barretos Cancer Hospital (1) · Community Medical Center, Scranton, PA (1) · Emory University (1) · Klein, Jeffrey A., M.D. (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1) · Misr University for Science and Technology (1) · National University Hospital, Singapore (1) · Northwell Health (1)
United States (13) · Australia (4) · Canada (3) · Brazil (2) · Iran (2) · Austria (1) · China (1) · Egypt (1) · France (1) · Germany (1) · Iceland (1) · Ireland (1) · Israel (1) · New Zealand (1) · Singapore (1)
Rinaldo Bellomo, MD, FRACP (3) · Thomas Hostetter, MD (2) · Abbas Soleimani, M.D. (1) · Ahmad Iaminisharif, M.D. (1) · Akbar Fotuhi, M.D. (1) · Alexander Zhu, DO (1) · Ali Farahani Vasheghani, M.D. (1) · Ali Kazemisaeid, M.D. (1) · Alireza Amirzadegan, M.D. (1) · Amir Hossein Razavi, M.D. (1) · Baback Roshanravan, MD (1) · Daniela Cejka, MD (1)
PMID 15150204, PMID 16391986, PMID 18202091, PMID 19112278, PMID 21816077, PMID 23062413, PMID 23393105, PMID 23553549, PMID 23610561, PMID 26301645, PMID 29758155, PMID 29850134, PMID 31699517, PMID 34028701, PMID 34543256, PMID 34784301, PMID 39356039
R01DK087783 (1), R01DK129793 (1), R01HL135183 (1)