7 completed, 7 unknown, 4 recruiting, 4 withdrawn. 28 Phase 2, 5 Phase 3, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 28 | Completed 7, Unknown 7, Recruiting 4, Withdrawn 4, Active not recruiting 3, Terminated 3 |
| Phase 3 | 5 | Unknown 2, Completed 1, Recruiting 1, Terminated 1 |
| Phase 1 | 3 | Unknown 3 |
Follow Saline injection: new trials by email Literature Review of Saline injection trials Research Report on Saline injection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SCARFREE-001: Verteporfin for Scar Prevention Verteporfin Injection, Saline injection - Surgical Scar | Phase 2 | Recruiting | Odense University Hospital | 12 | 2026-10-01 | 2026-10-27 |
| Cleft Lip Scarring After Botox Botulinum Toxin Type A (BOTOX) Injection, Normal Saline - Cleft Lip, Cleft Lip Scar | Phase 2 | Recruiting | Children's National Research Institute | 40 | 2026-02-19 | 2026-10-19 |
| Phase II Clinical Trial: Multi-dosing the BCG Vaccine for Fibromyalgia Bacillus Calmette Guerin Vaccine, Saline Injection - Fibromyalgia | Phase 2 | Withdrawn | Massachusetts General Hospital | 2026-01-01 | 2024-11-21 | |
| Mesenchymal Stem Cell and Exosome Therapy for Diabetic Erectile Dysfunction Umbilical Cord-Derived Mesenchymal Stem Cells, Umblical Cord-Derived Mesenchymal Stem Cell-Derived Exosomes, Placebo Intracavernosal Injection - Erectile Dysfunction With Diabetes Mellitus | Phase 2 / Phase 3 | Recruiting | Ankara City Hospital Bilkent | 90 | 2025-12-29 | 2026-03-18 |
| Improving Vaccine Protection for Adults AS01 adjuvant (0.5 mL intramuscular), YF17D (Stamaril, Sanofi-Pasteur), Placebo (NaCl 09%, 0.5mL) - Immune System Responses and Trained Immunity After AS01 Administration, Healthy Adult | Phase 2 | Recruiting | Singapore General Hospital | 40 | 2025-11-06 | 2026-06-15 |
| Peripheral Nerve Injections for CRPS Triamcinolone Acetonide 40mg/mL, Saline Injection, Bupivacaine - Complex Regional Pain Syndromes | Phase 2 | Unknown | Ottawa Hospital Research Institute | 50 | 2024-05-30 | 2024-09-19 |
| Repeat BCG Vaccinations for the Treatment of New Onset Type 1 Diabetes in Children Age 8-<18 Years Bacillus Calmette-Guérin, Saline Injection - Diabetes Mellitus, Type 1 Diabetes | Phase 2 | Active not recruiting | Massachusetts General Hospital | 100 | 2023-05-04 | 2026-06-26 |
| Repeat BCG Vaccinations For The Treatment Of Pediatric Type 1 Diabetes Bacillus Calmette-Guérin, Saline Injection - Diabetes Mellitus, Type 1, Diabetes type1 | Phase 2 | Active not recruiting | Massachusetts General Hospital | 150 | 2022-03-22 | 2026-06-26 |
| PRP Versus Saline in Lateral Epicondylitis Platelet rich plasma injection, Saline injection - Lateral Epicondylitis, Unspecified Elbow | Phase 2 / Phase 3 | Unknown | Singapore General Hospital | 70 | 2021-11-01 | 2021-11-18 |
| INVINCIBLE TRIAL: Intratumoral INT230-6 in Breast Cancer INT230-6, Saline injection - Breast Cancer | Phase 2 | Unknown | Ottawa Hospital Research Institute | 90 | 2021-03-25 | 2021-11-17 |
| Comparison of Non-Surgical Treatment Options for Chronic Exertional Compartment Syndrome (CECS) Supervised Gait Retraining, Home Based Gait Retraining, Saline Injection - Chronic Exertional Compartment Syndrome | Phase 2 | Completed | Walter Reed National Military Medical Center | 35 | 2020-11-05 | 2026-03-06 |
| Adductor Canal Block Ropivacaine injection, Saline Injection, Total Knee Arthroplasty - Osteoarthritis, Total Knee Replacement | Phase 2 / Phase 3 | Terminated | OrthoCarolina Research Institute, Inc. | 93 | 2020-10-09 | 2026-04-06 |
| Use of Autologous Platelet-Rich Plasma to Treat Hypertrophic Burn Scars PRP Injection, Saline Injection - Hypertrophic Scar | Phase 2 | Terminated | Vanderbilt University Medical Center | 3 | 2020-09-18 | 2023-01-09 |
| Treatment of Breast Cancer-related Lymphedema With Stem Cells and Fat Grafting Liposuction, Fat graft, Sham graf (Saline injection) - Lymphedema | Phase 2 | Completed | Odense University Hospital | 80 | 2018-12-18 | 2021-06-25 |
| Stellate Ganglion Blockade in Post-Menopausal Women Stellate Ganglion Block Injection with Bupivicaine, Saline injection - Hot Flashes, Hot Flushes | Phase 2 | Withdrawn | Northwestern University | 2018-07-10 | 2025-07-23 | |
| Intracavernosal Injection of Botulinum Toxin Type A (50 and 100 Unit) in the Treatment of Erectile Dysfunction saline injection, Botulinum toxin type A 50 units, Botulinum toxin type A 100 units - Erectile Dysfunction, Botulinum Toxin | Phase 2 | Completed | Benha University | 200 | 2016-07-12 | 2019-11-26 |
| Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes Bacillus Calmette-Guérin, Saline injection - Diabetes Mellitus, Type One, Diabetes Mellitus, Type I | Phase 2 | Active not recruiting | Massachusetts General Hospital | 150 | 2015-06-01 | 2026-04-13 |
| Micronized dHACM Injectable for the Treatment of Plantar Fasciitis AmnioFix® Injectable, Saline Injection - Fasciitis, Plantar | Phase 2 / Phase 3 | Completed | MiMedx Group, Inc. | 147 | 2015-03-31 | 2020-11-17 |
| Subcutaneous Sterile Water Injection for Relief of Low Back Pain Subcutaneous sterile water injection, saline injection - Low Back Pain | Phase 1 / Phase 2 | Unknown | Woman's Health University Hospital, Egypt | 336 | 2015-02-01 | 2016-06-27 |
| Botulinum Toxin for the Management of Chronic Orchialgia Botox Injection, Normal saline injection - Chronic Testicular Pain | Phase 2 | Completed | Wake Forest University Health Sciences | 8 | 2014-11-01 | 2018-09-05 |
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Diabetes Mellitus, Type 1 (4) · Diabetes Mellitus (3) · Erectile Dysfunction (2) · Low Back Pain (2) · Arterial Occlusive Diseases (1) · Back Pain (1) · Breast Neoplasms (1) · COVID-19 (1) · Chronic Exertional Compartment Syndrome (1) · Cicatrix (1) · Cicatrix, Hypertrophic (1) · Cleft Lip (1) · Colorectal Neoplasms (1) · Complex Regional Pain Syndromes (1) · Diabetic Foot (1)
Massachusetts General Hospital (4) · Odense University Hospital (2) · Ottawa Hospital Research Institute (2) · Singapore General Hospital (2) · Ankara City Hospital Bilkent (1) · Baylor College of Medicine (1) · Benha University (1) · CHU de Quebec-Universite Laval (1) · Children's National Research Institute (1) · Emory University (1) · Franziskus-Krankenhaus (1) · Hadassah Medical Organization (1) · Mesoblast, Ltd. (1) · MiMedx Group, Inc. (1) · Northwestern University (1)
United States (14) · Canada (3) · Denmark (2) · Australia (1) · Chile (1) · China (1) · Germany (1) · Israel (1) · Singapore (1) · Turkey (Türkiye) (1)
Denise L Faustman, MD, PhD (3) · Alejandro D. Mesples, MD (1) · Amit Singhal, B.Sc., M.Sc., Ph.D. (1) · Angel Arnaout, MD (1) · Arif Awan, MD (1) · Berthold Amann, MD (1) · Bryan D Springer, MD (1) · Candice Y.Y. Chan, MBChB, MRCP (1) · Charles W Hogue, MD (1) · Christopher P. Smith, MD (1) · Craig Campbell, MD MSc FRCPC (1) · David Hebbelstrup Jensen, MD, Ph.d. (1) · Erkan Olcucuoglu, MD, Associate Professor (1) · Galen Perdikis, MD (1) · Jack Puymirat, MD (1)
PMID 25926350, PMID 36027906, PMID 39591365
2025 (1)