16 completed, 9 recruiting, 6 unknown, 2 withdrawn. 25 Not applicable, 4 Phase 2, 3 Phase 1, 3 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Psilocybin-Assisted Therapy psilocybin, Supportive Therapy, Prolonged Exposure Therapy - PTSD | Phase 2 | Recruiting | Emory University | 150 | 2026-06-08 | 2026-10-01 |
| Service Dogs and Prolonged Exposure Therapy for Military-Connected PTSD Psychiatric Service Dog, Prolonged Exposure Therapy - Stress Disorders, Post-Traumatic, PTSD | Not applicable | Enrolling by invitation | University of Arizona | 216 | 2025-09-23 | 2026-02-20 |
| Shared Decision Making in PTSD Treatment Prolonged Exposure Therapy, Cognitive Processing Therapy, Written Exposure Therapy - Post Traumatic Stress Disorder PTSD | Not applicable | Recruiting | The University of Texas Health Science Center at San Antonio | 200 | 2025-05-09 | 2026-08-19 |
| Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure Trauma Informed Guilt Reduction Therapy, Prolonged Exposure Therapy - Stress Disorders, Post-Traumatic | Not applicable | Recruiting | Veterans Medical Research Foundation | 158 | 2024-12-01 | 2026-08-25 |
| Deep Brain Stimulation for Refractory PTSD Open Label Deep Brain Stimulation, Double blinded Deep Brain Stimulation, Prolonged exposure therapy - PTSD | Phase 1 | Recruiting | Sunnybrook Health Sciences Centre | 20 | 2024-11-01 | 2024-11-26 |
| Massed Prolonged Exposure for PTSD in Substance Use Treatment Prolonged Exposure Therapy - Stress Disorders, Post-Traumatic, Substance Use Disorders | Not applicable | Recruiting | Veterans Medical Research Foundation | 200 | 2024-09-01 | 2026-08-27 |
| Evaluating Treatments for Suicidal Veterans With PTSD Dialectical Behavior Therapy, Dialectical Behavior Therapy Prolonged Exposure protocol, Prolonged Exposure therapy - Self-directed Violence, Post-traumatic Stress Disorder (PTSD) | Not applicable | Recruiting | VA Office of Research and Development | 125 | 2024-07-08 | 2026-07-16 |
| Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD Prolonged exposure therapy, Financial incentives, Treatment as usual - Opioid Use Disorder, Posttraumatic Stress Disorder | Not applicable | Recruiting | University of Vermont | 135 | 2024-06-03 | 2026-05-18 |
| PT-STRESS Study: Predicting Treatment Success and Dealing With Non-response in the Treatment of PTSD Prolonged Exposure therapy, Eye Movement Desensitization Reprocessing (EMDR), Interpersonal Psychotherapy (IPT) - Stress Disorders, Post-Traumatic | Not applicable | Recruiting | University of Groningen | 442 | 2024-01-01 | 2024-02-28 |
| MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress Disorder Prolonged exposure therapy, MDMA, Niacin - PTSD, Alcohol Use Disorder | Phase 2 | Unknown | University of Sydney | 120 | 2023-09-19 | 2023-11-07 |
| A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD Prolonged Exposure Therapy, Pharmacotherapy with paroxetine or venlafaxine XR - Posttraumatic Stress Disorder | Phase 4 | Active not recruiting | University of Pennsylvania | 304 | 2022-05-25 | 2026-06-09 |
| General Psychological Distress, PTSD, and Co-Morbidities in Healthcare Workers Consequent to Occupational Trauma Medical Music, Narrative Writing, Prolonged Exposure Therapy - Post-traumatic Stress Disorder, Moral Injury | Not applicable | Recruiting | Weill Medical College of Cornell University | 120 | 2022-01-20 | 2026-06-22 |
| TDCS-Augmented Prolonged Exposure Therapy Transcranial Direct Current Stimulation (tDCS), Prolonged Exposure Therapy - Posttraumatic Stress Disorder, PTSD | Not applicable | Withdrawn | Medical University of South Carolina | 2021-10-01 | 2024-10-24 | |
| Psychotherapy for PTSD Among Veterans Also Receiving Drug or Alcohol Treatment Prolonged Exposure Therapy, Cognitive Processing Therapy, Present Centered Therapy - Stress Disorders, Post-Traumatic, Substance Use Disorders | Not applicable | Completed | Center for Veterans Research and Education | 426 | 2020-12-08 | 2024-06-25 |
| Management of Chronic Pain and PTSD in Gulf War Veterans With tDCS+Prolonged Exposure Home-based tDCS, Prolonged Exposure Therapy - Chronic Pain, PTSD | Not applicable | Completed | The University of Texas Health Science Center, Houston | 21 | 2020-01-15 | 2023-02-03 |
| Prolonged Exposure Therapy for PTSD and Opioid Use Disorder Prolonged Exposure Therapy, Attendance-based monetary incentives - Post Traumatic Stress Disorder, Opioid-use Disorder | Not applicable | Completed | University of Vermont | 82 | 2019-11-08 | 2026-06-11 |
| Outcomes After Spinal Cord Injury (OASIS) Prolonged Exposure Therapy - Posttraumatic Stress Disorder, Spinal Cord Injuries | Not applicable | Completed | Baylor Research Institute | 30 | 2018-02-21 | 2026-01-23 |
| Shortened Prolonged Exposure Therapy for Chronic PTSD in Taiwanese Adults Prolonged Exposure Therapy - Posttraumatic Stress Disorder | Not applicable | Unknown | Chang Gung University | 8 | 2018-01-10 | 2018-01-08 |
| A fMRI Study of the Treatment of Danish Veterans With PTSD With Prolonged Exposure Therapy Prolonged Exposure Therapy, Observation, fMRI - Stress Disorders, Post-Traumatic | Not applicable | Unknown | Aalborg University Hospital | 60 | 2016-01-01 | 2016-08-10 |
| Efficacy of 60-minute Versus 90-minute Sessions in Treating PTSD Using Prolonged Exposure Prolonged Exposure Therapy - Posttraumatic Stress Disorder, PTSD | Not applicable | Completed | University of Pennsylvania | 160 | 2013-09-01 | 2021-09-17 |
Showing 20 of 35. Sign in to see all of them.
Stress Disorders, Post-Traumatic (34) · Wounds and Injuries (7) · Anxiety Disorders (6) · Substance-Related Disorders (5) · Combat Disorders (3) · Depression (2) · Opioid-Related Disorders (2) · Alcoholism (1) · Behavior, Addictive (1) · Brain Concussion (1) · Brain Injuries, Traumatic (1) · Chronic Pain (1) · HIV Infections (1) · Human-Animal Bond (1) · Mental Disorders (1)
University of Pennsylvania (3) · Veterans Medical Research Foundation (3) · Emory University (2) · University of Vermont (2) · Aalborg University Hospital (1) · Baylor Research Institute (1) · Bronx VA Medical Center (1) · Center for Veterans Research and Education (1) · Chang Gung University (1) · Duke University (1) · Johns Hopkins University (1) · Kent State University (1) · Massachusetts General Hospital (1) · Medical University of South Carolina (1) · National Institute of Mental Health (NIMH) (1)
United States (27) · Israel (2) · Australia (1) · Canada (1) · Netherlands (1) · Taiwan (1)
Shannon Kehle-Forbes, PhD (3) · Edna B. Foa, Ph.D. (2) · Adam R. Cobb, Ph.D. (1) · Alan L Peterson, PhD (1) · Anna Wise, PhD (1) · Barbara O Rothbaum, PhD, ABPP (1) · Bethany C. Wangelin, Ph.D. (1) · Douglas L Delahanty, PhD (1) · Edna B. Foa, PhD (1) · Eva Gilboa-Schechtman, PhD (1) · Franklin Schneier, MD (1) · Hildi Hagedorn, PhD (1) · Jessica Peirce, Ph.D. (1) · JoAnn Difede, PhD (1) · John C. Markowitz, MD (1)
PMID 12182270, PMID 14629992, PMID 16551156, PMID 20855048, PMID 21908494, PMID 25677355, PMID 26115532, PMID 26439430, PMID 28376282, PMID 28743198, PMID 29081351, PMID 30516797, PMID 30773148, PMID 32216142, PMID 32278278, PMID 32306485, PMID 32446108, PMID 32668087, PMID 34133087, PMID 34147766, PMID 35771512, PMID 35808998, PMID 35842108, PMID 35987487, PMID 37585569, PMID 38698315, PMID 39207423, PMID 39642783, PMID 42115843, PMID 42409408, PMID 42603614, PMID 42766718
P20GM103644 (1), R01DA057308 (1), R01MH051509 (1), R01MH062003 (1), R01MH068173 (1), R01MH079078 (1)