57 completed, 15 terminated, 10 unknown, 6 recruiting. 29 Phase 2, 27 Phase 4, 26 Not applicable, 12 Phase 3, 5 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial testosterone cypionate, finasteride, placebo injection - Spinal Cord Injury, Spinal Cord Injuries | Phase 2 / Phase 3 | Not yet recruiting | VA Office of Research and Development | 300 | 2027-10-01 | 2026-08-04 |
| Ginger's Therapeutic Potential in Asthma Ginger Extract, Placebo - Asthma | Phase 2 | Not yet recruiting | Emily DiMango, MD | 32 | 2026-11-01 | 2026-08-28 |
| Methylphenidate and Response to Alcohol Cues Methylphenidate Pill, Placebo Pill - Alcohol Use Disorder | Phase 2 | Not yet recruiting | University of Florida | 50 | 2026-10-01 | 2026-08-20 |
| NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease Droxidopa Oral Product, Placebo Control - Menkes Disease | Phase 1 / Phase 2 | Recruiting | Stephen G. Kaler | 6 | 2026-08-10 | 2026-10-05 |
| Analgesic Efficacy of Pre-Operative Dose of Palmitoylethanolamide in Patients Undergoing Total Knee Arthroplasty Effect of two different drugs on post operative pain after TKA - Total Knee Replacement | Phase 1 / Phase 2 | Not yet recruiting | Abdelrahman Gaber Sayed Elkhateeb | 1 | 2026-01-13 | 2026-01-09 |
| Pramipexole to Enhance Social Connections Pramipexole Pill, Placebo Pill - Anxiety Disorders, Anxiety | Phase 2 | Active not recruiting | University of California, San Diego | 108 | 2024-05-13 | 2026-10-13 |
| Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2) Ketamine, Naltrexone Pill, Placebo pill - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Stanford University | 150 | 2024-02-24 | 2026-04-24 |
| RCT of an Oral Acne Supplement for Adult Women Skin Nutraceutical Supplement, Placebo pill - Acne | Not applicable | Completed | Nutraceutical Wellness Inc. | 102 | 2024-01-15 | 2024-09-25 |
| D-cycloserine Augmented Treatment for Youth With Tic Disorders d-cycloserine, Placebo pill, Behavior Therapy - Tourette Syndrome | Early Phase 1 | Withdrawn | Johns Hopkins University | 2023-04-15 | 2023-04-14 | |
| Benefits of Nicotinamide Riboside Upon Cognition and Sleep Nicotinamide riboside, Placebo - Cognitive Impairment, Sleep Quality | Not applicable | Recruiting | State University of New York at Buffalo | 50 | 2023-04-04 | 2026-09-24 |
| Celecoxib in Postoperative Analgesia for Radius Fracture Surgery Celecoxib 100 mg, Placebo - Pain, Postoperative | Phase 4 | Completed | Charles University, Czech Republic | 42 | 2022-02-10 | 2024-02-07 |
| Oral Tamoxifen vs. TamGel vs. Control in Women With Atypical Hyperplasia, Lobular Carcinoma In Situ, or Increased Breast Cancer Risk Tamoxifen, Topical 4-OHT( 4-hydroxytamoxifen)gel 4 mg/each breast/day, Placebo - Breast Atypical Hyperplasia, Breast Lobular Carcinoma in Situ | Phase 2 | Terminated | Mayo Clinic | 65 | 2021-07-26 | 2026-09-24 |
| Antibiotic Prophylaxis for Bladder Botox Ciprofloxacin, Placebo Pill - Idiopathic Overactive Bladder, Postoperative Urinary Tract Infection | Phase 4 | Recruiting | University of Alberta | 202 | 2021-06-28 | 2026-09-22 |
| Dapagliflozin Effects on Coronary Calcium and Epicardial Fat Assessed by Cardiotomography Dapagliflozin 10Mg Tab, Placebo - Diabete Type 2, Unstable Angina | Phase 3 | Completed | Hilda Elizabeth Macías Cervantes | 54 | 2021-06-21 | 2023-08-21 |
| Efficacy and Safety of Gushen Antai Pill on Ongoing Pregnancy Rate in Women With Normal Ovarian Reserve Undergoing IVF-ET Gushen Antai Pill, Placebo pill - Infertility, Female | Phase 4 | Recruiting | Shandong University of Traditional Chinese Medicine | 800 | 2021-06-15 | 2026-03-10 |
| Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms Accelerometer, placebo pill, Midodrine or atomoxetine pill - Orthostatic; Hypotension, Neurogenic, Autonomic Failure | Not applicable | Recruiting | Vanderbilt University Medical Center | 29 | 2021-02-05 | 2026-07-02 |
| Studying the Role of Brain Molecules for Decision Making Methylphenidate, Reboxetine, Nicotine gum - Decision Making, Healthy | Not applicable | Completed | University of Zurich | 160 | 2020-12-17 | 2024-05-08 |
| Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients Midodrine, Placebo pill, Abdominal compression - Neurogenic Orthostatic Hypotension, Autonomic Failure | Early Phase 1 | Completed | Vanderbilt University Medical Center | 31 | 2020-11-09 | 2026-08-07 |
| Saved From COVID-19 - Chloroquine (CQ) Prophylaxis for Health Care Workers at Risk for COVID Chloroquine, Placebo oral tablet - COVID, Coronavirus Infection | Phase 2 | Terminated | Columbia University | 5 | 2020-04-21 | 2025-02-27 |
| Cocoa-rich Bioflavanol Supplementation Effects During Cold Exposure CocoaVia supplement, Placebo Pill - Cold Exposure, Manual Dexterity | Not applicable | Unknown | United States Army Research Institute of Environmental Medicine | 40 | 2020-01-13 | 2021-04-30 |
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Diabetes Mellitus, Type 2 (5) · Tobacco Use Disorder (5) · Alcoholism (4) · Insulin Resistance (4) · Motor Activity (4) · Vitamin D Deficiency (4) · Diabetes Mellitus (3) · Hypotension, Orthostatic (3) · Multiple System Atrophy (3) · Pure Autonomic Failure (3) · Sleep Apnea, Obstructive (3) · Smoking Cessation (3) · Stress Disorders, Post-Traumatic (3) · Acne Vulgaris (2) · Alzheimer Disease (2)
Brigham and Women's Hospital (5) · Columbia University (4) · Hospital de Clinicas de Porto Alegre (3) · University of Guelph (3) · Vanderbilt University Medical Center (3) · Duke University (2) · NYU Langone Health (2) · Stanford University (2) · The Mind Research Network (2) · TriHealth Inc. (2) · Tulane University School of Medicine (2) · United States Army Research Institute of Environmental Medicine (2) · University of California, San Francisco (2) · University of Colorado, Boulder (2) · University of Pennsylvania (2)
United States (62) · Brazil (5) · Canada (5) · Switzerland (3) · China (2) · Egypt (2) · Mexico (2) · Turkey (Türkiye) (2) · Australia (1) · Bangladesh (1) · Czechia (1) · Denmark (1) · France (1) · Israel (1) · Peru (1)
Christian Hendershot, Ph.D. (2) · Eric Claus, Ph.D. (2) · Italo Biaggioni, MD (2) · Joshua F Yarrow, PhD MS BS (2) · Lawrence L Spriet, PhD (2) · Michael S Scheeringa, MD, MPH (2) · Philippe Tobler, PhD (2) · Adam L. Boxer, M.D., Ph.D. (1) · Ali Ahiskalioglu, Ass.Prof. (1) · Amy Degnim, M.D. (1) · Amy Janes, Ph.D. (1) · Anca Askanase, MD, MPH (1) · Andrea Bonny, MD (1) · Andrea Nackley, PhD (1) · Ann Duerr, MD, PhD, MPH (1)
PMID 24506079, PMID 28569390, PMID 11239408, PMID 17846259, PMID 19755697, PMID 20716308, PMID 20817153, PMID 21148807, PMID 21797916, PMID 21816786, PMID 22266332, PMID 22341881, PMID 22694905, PMID 23290598, PMID 24081940, PMID 24401940, PMID 25003376, PMID 25564570, PMID 25719754, PMID 25906818, PMID 25937196, PMID 26555871, PMID 26606676, PMID 26867076, PMID 27367832, PMID 27634790, PMID 28212390, PMID 28323960, PMID 28409851, PMID 28473401, PMID 29275373, PMID 29468508, PMID 29635383, PMID 29661838, PMID 29669139, PMID 30149332, PMID 30877851, PMID 31504439, PMID 31699704, PMID 32151567, PMID 32559759, PMID 32583982, PMID 33184328, PMID 33303068, PMID 33618922, PMID 34134828, PMID 34420816, PMID 34665204, PMID 35082139, PMID 36269028
R01HL144568 (2), UH3TR000958 (2), 1RC1MH088969-01 (1), I01RX001449 (1), K23AG019161 (1), P01HL095491 (1), P30DK019525 (1), R01AA032400 (1), R01AR059086 (1), R01CA237607 (1), R01DA027151 (1), R01DK084986 (1), R01HD096331 (1), R01HL102321 (1), R01HL109031 (1)