14 completed, 4 not yet recruiting, 4 recruiting, 1 withdrawn. 10 Phase 4, 9 Not applicable, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 10 | Completed 7, Recruiting 2, Withdrawn 1 |
| Not applicable | 9 | Completed 4, Not yet recruiting 3, Recruiting 2 |
| Phase 3 | 3 | Completed 3 |
Follow Oliceridine: new trials by email Literature Review of Oliceridine trials Research Report on Oliceridine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oliceridine Versus Sufentanil Analgesia for Postoperative Patients With Obstructive Sleep Apnea Oliceridine, Sufentanil - Obstructive Sleep Apnea, Postoperative Analgesia | Not yet recruiting | Peking University First Hospital | 851 | 2026-09-01 | 2026-08-11 | |
| Remimazolam Combined With Oliceridine for Sedation in Elderly Patients Undergoing Gastrointestinal Endoscopy Remimazolam Tosilate for Injection, Oliceridine Fumarate - Sedation, Gastrointestinal Endoscopy | Not applicable | Completed | Baoshan Branch, Renji Hospital, Shanghai Jiao Tong University School of Medicine | 240 | 2026-07-17 | 2026-11-03 |
| Oliceridine vs Sufentanil for Cough During Anesthesia Induction Oliceridine, Sufentanil - Cough, Anesthesia | Phase 4 | Recruiting | Shiyou Wei | 62 | 2026-06-27 | 2026-07-21 |
| Dexmedetomidine-Enhanced PCIA After Lobectomy in Nicotine-Dependent Patients Oliceridine, Dexmedetomidine - Postoperative Pain Management | Phase 4 | Withdrawn | Shenyang Sixth People's Hospital | 2026-06-01 | 2026-04-13 | |
| Oliceridine Versus Sufentanil for Blood Pressure Control During Anesthesia Induction in Older Women With Hypertension Undergoing Gynecological Laparoscopic Surgery Oliceridine, Sufentanil - Hypotension, Hypertension | Phase 4 | Completed | Xingguo Xu | 134 | 2026-05-15 | 2026-10-13 |
| Oliceridine for Remifentanil-Induced Postoperative Hyperalgesia Oliceridine, sufentanil - Postoperative Hyperalgesia | Phase 4 | Completed | Xingguo Xu | 130 | 2026-05-01 | 2026-11-03 |
| Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery Oliceridine, Sufentanil - PONV, Cerebellopontine Angle Tumor | Not applicable | Recruiting | Xuanwu Hospital, Beijing | 174 | 2026-03-25 | 2026-05-22 |
| Effect of Oliceridine Patient-Controlled Intravenous Analgesia on Postoperative Chronic Pain After Video-Assisted Thoracoscopic Lung Resection Oliceridine, Sufentanil - Chronic Postsurgical Pain | Phase 4 | Recruiting | Tianjin Medical University General Hospital | 320 | 2026-01-06 | 2026-09-01 |
| Effects and Safety of Oliceridine in Anesthesia Induction:A Randomised Controlled Trial Oliceridine, Sufentanil - Gynecological Laparoscopic Surgery, General Anesthetic | Not applicable | Completed | Tangshan Maternal and Child Health Hospital | 120 | 2025-10-01 | 2026-01-28 |
| Respiratory Safety of Oliceridine During Sedated Gastrointestinal Endoscopy Oliceridine, Sufentanil - Hypoxemia During Surgery, Gastrointestinal Endoscopy | Not applicable | Completed | Shiyou Wei | 508 | 2025-09-22 | 2026-09-04 |
| Efficacy of Oxalidine and Sufentanil in Strabismus Correction Oliceridine, Sulfentanil - Strabismus Surgery | Not applicable | Not yet recruiting | Henan Provincial People's Hospital | 290 | 2025-08-01 | 2025-08-08 |
| Comparison of the Efficacy and Safety of Oliceridine and Sufentanil in Patients Undergoing Outpatient Hysteroscopy Sufentanil, Oliceridine - Hysteroscopy, Analgeisa | Not applicable | Completed | Tangshan Maternal and Child Health Hospital | 225 | 2025-08-01 | 2026-07-20 |
| Oliceridine on Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery Oliceridine, Sufentanil - Gynecologic Surgical Procedures, Postoperative Nausea and Vomiting (PONV) | Phase 4 | Completed | YanYing Xiao | 96 | 2025-07-21 | 2026-06-09 |
| Analgesic Effect and Safety of Oliceridine and Oxycodone in Vitrectomy Oliceridine, Oxycodone - Vitrectomy | Not applicable | Not yet recruiting | Henan Provincial People's Hospital | 120 | 2025-07-01 | 2025-07-31 |
| Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia in Lumbar Surgeries: a Randomized Control Trial Oliceridine, Morphine, Sufentanil - Sufentanil, Morphine | Not applicable | Recruiting | Anqing Municipal Hospital | 90 | 2025-06-01 | 2026-06-01 |
| Clinical Study of G Protein Biased Μ - Opioid Receptor Agonist Oliceridine for Optimizing Postoperative Analgesia Under General Anesthesia Oliceridine, Sulfentanil - Old Age | Not applicable | Not yet recruiting | Henan Provincial People's Hospital | 150 | 2024-11-01 | 2024-10-31 |
| To Evaluate the Efficacy and Safety of Tegileridine and Oliceridine Injections in the Treatment of Postoperative Pain Tegileridine, Oliceridine, Morphine - Analgesia | Phase 4 | Completed | Yuwei Qiu | 75 | 2024-07-03 | 2025-01-01 |
| Effect of Oliceridine Analgesia on Postoperative Nause and Vomiting Oliceridine, Morphine - Laparoscopic Colorectal Surgery, Postoperative Analgesia | Phase 4 | Completed | Peking University First Hospital | 252 | 2024-07-02 | 2026-06-24 |
| Oliceridine in Patients With Acute Burn Injuries Oliceridine, Historical opioid use - Acute Pain, Burns | Phase 4 | Completed | University of Tennessee | 31 | 2023-04-01 | 2023-10-26 |
| Intravenous Oliceridine and Opioid-related Complications Oliceridine - Major Surgery | Phase 4 | Completed | The Cleveland Clinic | 204 | 2021-09-15 | 2026-05-14 |
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Acute Pain (4) · Postoperative Nausea and Vomiting (4) · Agnosia (2) · Hypoxia (2) · Respiratory Insufficiency (2) · Burns (1) · Cough (1) · Drug-Related Side Effects and Adverse Reactions (1) · Hypertension (1) · Hypotension (1) · Neuroma, Acoustic (1) · Pain (1) · Pain, Postoperative (1) · Sleep Apnea, Obstructive (1)
Henan Provincial People's Hospital (3) · Trevena Inc. (3) · Peking University First Hospital (2) · Shiyou Wei (2) · Tangshan Maternal and Child Health Hospital (2) · Xingguo Xu (2) · Anqing Municipal Hospital (1) · Baoshan Branch, Renji Hospital, Shanghai Jiao Tong University School of Medicine (1) · Shenyang Sixth People's Hospital (1) · The Cleveland Clinic (1) · Tianjin Medical University General Hospital (1) · University of Tennessee (1) · Xuanwu Hospital, Beijing (1) · YanYing Xiao (1) · Yuwei Qiu (1)
China (15) · United States (5)
Franck Skobieranda, MD (3) · Daniel I Sessler, MD (1) · Dong-Xin Wang, MD, PhD (1) · Dong-Xin Wang, PHD (1) · Jiaqiang Zhang (1) · Shiyou Wei (1) · Shiyou Wei, PhD (1) · Yang Jiao, Doctor (1)
PMID 31162798, PMID 10740539, PMID 16846542, PMID 23300227, PMID 24157979, PMID 28420629, PMID 30426190, PMID 30881102, PMID 31388805, PMID 31567573, PMID 31814753, PMID 32467512, PMID 33025536, PMID 33210266, PMID 34351590, PMID 36909334, PMID 37556070, PMID 37629444, PMID 37892882, PMID 37927993, PMID 40446423