32 completed, 15 unknown, 7 recruiting, 5 terminated. 66 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 66 | Completed 32, Unknown 15, Recruiting 7, Terminated 5, Not yet recruiting 3, Enrolling by invitation 2, Active not recruiting 1, Withdrawn 1 |
Follow Norepinephrine: new trials by email Literature Review of Norepinephrine trials Research Report on Norepinephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| OB VEGA-Phenylephrine vs Norepinephrine Outcomes Phenylephrine, Norepinephrine - Hypotension During Surgery, Cesarean Birth | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 1500 | 2027-01-01 | 2026-10-28 |
| Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock Angiotensin II, Norepinephrine - Septic Shock | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 78 | 2026-11-01 | 2026-09-24 |
| Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE) Dopamine administration, Norepinephrine - Hypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN) | Phase 4 | Recruiting | University of California, Davis | 30 | 2026-10-30 | 2026-08-18 |
| Phenotype Guided Vasoactive Medication During Kidney Transplantation Phenotype-Guided Vasoactive Management - Kidney Transplant, Fluid Management | Phase 4 | Enrolling by invitation | Jennifer Cutler | 255 | 2026-06-01 | 2026-10-22 |
| Comparison of Norepinehrine Versus Phenylepherine Infusion for Prevention of Post-spinal Hypotension Norepinephrine, Phenylephrine - Patients Undergoing Orthopedic Hip Surgery Under Spinal Anesthesia, Orthopedic Hip Sugery in Eldely Patients | Phase 4 | Recruiting | Sohag University | 62 | 2026-05-22 | 2026-06-23 |
| Low-dose Norepinephrine Infusion for Prevention of Post-induction Hypotension in Emergency Surgery for Peritonitis Norepinephrine (0.05 μg/kg/min), Placebo - Secondary Peritonitis, Post-induction Hypotension | Phase 4 | Not yet recruiting | Bach Mai Hospital | 60 | 2026-04-01 | 2026-04-14 |
| Ephedrine Versus Norepinephrine and Fetal Acid-Base Status During Cesarean Delivery Under Spinal Anesthesia Norepinephrine, Ephedrine - Cesarean Delivery Affecting Newborn, Acidosis | Phase 4 | Completed | mehmet özkılıç | 155 | 2025-09-01 | 2026-10-08 |
| The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery Norepinephrine, Phenylephrine - Anesthesia, Surgery With General Anesthesia | Phase 4 | Recruiting | University of California, San Francisco | 18000 | 2025-04-01 | 2026-05-26 |
| Norepinephrine ED90 Bolus After Spinal Anesthesia in Cesarean Section Norepinephrine - Hypotension, Hypertension | Phase 4 | Completed | Pontificia Universidad Catolica de Chile | 60 | 2025-04-01 | 2025-08-29 |
| Management of Post-Induction Hypotension in Emergency Abdominal Surgery Ephedrine (6 mg boluses), Norepinephrine (10 µg boluses) - Post-induction Hypotension | Phase 4 | Terminated | Hopital Charles Nicolle | 100 | 2025-03-06 | 2025-12-11 |
| Leg Wrapping and Norepinephrine for Prevention of Post Spinal Hypotension in C.S Norepinephrine, Leg wrapping - Post Spinal Hypotension | Phase 4 | Completed | Fayoum University | 168 | 2024-08-01 | 2025-05-30 |
| Norepinephrine on Maternal Hypotension After Combined Lumbar and Epidural Anaesthesia Norepinephrine - Maternal Hypotension | Phase 4 | Unknown | The Third People's Hospital of Bengbu | 100 | 2024-07-01 | 2024-07-12 |
| Norepinephrine vs. Phenylephrine for Hypotension in Low-Dose Spinal Anesthesia for Cesarean Delivery Norepinephrine, Phenylephrine - Anesthesia, Spinal | Phase 4 | Completed | Tam Anh Research Institute | 100 | 2024-06-06 | 2026-01-21 |
| Inotropic Effects of Vasopressin Versus Noradrenaline In Patients With Vasoplegic Syndrome After Cardiac Surgery Vasopressin intravenous infusion, Norepinephrine intravenous infusion - Vasoplegic Syndrome of Cardiac Surgery | Phase 4 | Recruiting | University of Sao Paulo | 350 | 2024-04-01 | 2025-04-30 |
| Efficacy of the Use of Vasopressin as a Primary Vasoconstrictor in Critically Ill Patients Initiation of vasopressine as a first vasoconstrictive drug, Initiation of noradrenaline as a first vasoconstrictive drug - Circulatory Shock | Phase 4 | Unknown | University of Thessaly | 145 | 2023-12-15 | 2024-03-06 |
| Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction Plasma-lyte (static group), Norepinephrine (static group), Plasma-lyte (dynamic group) - Hypotension During Surgery | Phase 4 | Terminated | Algemeen Ziekenhuis Maria Middelares | 41 | 2023-11-23 | 2026-10-28 |
| Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate - Vasoconstriction, Vasodilation | Phase 4 | Recruiting | University of Alberta | 30 | 2023-10-31 | 2026-01-08 |
| Norepinephrine Prevent Post-induction Hypotension in High-risk Patients Norepinephrine Hydrochloride, Placebo - Anesthesia, Blood Pressure | Phase 4 | Unknown | First Affiliated Hospital of Kunming Medical University | 180 | 2023-10-01 | 2023-09-08 |
| Hypotension Prediction Index vs Norepinephrine Infusion for Prevention of Spinal Hypotension for Cesarean Delivery Hypotension Prediction Index, Norepinephrine - Hypotension During Surgery, Hypotension Drug-Induced | Phase 4 | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 150 | 2023-09-01 | 2023-08-03 |
| Early Administration of Norepinephrine in Sepsis Norepinephrine Bitartrate, Placebo - Sepsis, Severe | Phase 4 | Recruiting | Tunis University | 200 | 2023-08-01 | 2024-12-04 |
Showing 20 of 66. Sign in to see all of them.
Hypotension (16) · Shock, Septic (9) · Diabetes Insipidus (6) · Sepsis (5) · Shock (5) · Acute Kidney Injury (2) · Arrhythmias, Cardiac (2) · Critical Illness (2) · Head and Neck Neoplasms (2) · Hypertension (2) · Postoperative Complications (2) · Tachycardia (2) · Acidosis (1) · Aneurysm (1) · Atrial Fibrillation (1)
Cairo University (5) · Kasr El Aini Hospital (3) · University Tunis El Manar (3) · Algemeen Ziekenhuis Maria Middelares (2) · Medical University of Vienna (2) · Sahlgrenska University Hospital (2) · University of California, San Francisco (2) · Wake Forest University Health Sciences (2) · Bach Mai Hospital (1) · Centre Hospitalier Régional d'Orléans (1) · Cukurova University (1) · Fayoum University (1) · Federal University of São Paulo (1) · First Affiliated Hospital of Kunming Medical University (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1)
United States (12) · Egypt (10) · China (6) · Tunisia (5) · Belgium (4) · Brazil (4) · Netherlands (3) · Turkey (Türkiye) (3) · Austria (2) · Canada (2) · France (2) · Greece (2) · Sweden (2) · Vietnam (2) · Chile (1)
Ahmed Mukhtar, Professor (2) · Ahlem Trifi (1) · Ahmed Hasanin, Professor (1) · Ahmed M Hasanin, Professor (1) · Ahmed M Mukhtar, Professor (1) · Alain F Kalmar, MD, PhD (1) · Allison Janda, MD (1) · Ashish Khanna, MD (1) · B. S Segal, MD (1) · Carmen A Pfortmueller, MD (1) · Cassio Mallmann, MD (1) · Christiaan Boerma, Dr (1) · Craig Steinback, PhD (1)
PMID 18305265, PMID 27483065, PMID 28973220, PMID 29600824, PMID 32303180, PMID 34605781, PMID 36279409, PMID 11529214, PMID 12519925, PMID 12794416, PMID 14980943, PMID 16192766, PMID 16879732, PMID 19926252, PMID 20156348, PMID 20725823, PMID 22518026, PMID 22929242, PMID 23796235, PMID 25004265, PMID 25032942, PMID 25635593, PMID 25887027, PMID 26903338, PMID 27398737, PMID 28618919, PMID 28678073, PMID 28750598, PMID 28820036, PMID 28903154, PMID 29319721, PMID 29328496, PMID 29406176, PMID 29784057, PMID 29859008, PMID 30335625, PMID 31008870, PMID 31060591, PMID 31094744, PMID 31958982, PMID 31983763, PMID 33483132, PMID 33977793, PMID 34404892, PMID 34752520, PMID 35780092, PMID 36018257, PMID 36925330, PMID 38242802, PMID 38264276
2008 (1), 2019 (1), R01DK139484 (1), R01HL177834 (1), UL1RR024975-01 (1), UL1TR000445-06 (1)