9 completed, 3 unknown, 2 withdrawn, 1 enrolling by invitation. 18 Phase 2, 7 Phase 3, 2 Phase 1.
Follow Norepinephrine: new trials by email Literature Review of Norepinephrine trials Research Report on Norepinephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Vasopressin Versus Norepinephrine on Post-operative Mean Pulmonary Arterial Pressure Following Pulmonary Endarterectomy Surgery, Vasopressin, Norepinephrine - Anesthesia, Pulmonary Hypertension | Phase 2 | Not yet recruiting | Fondation Hôpital Saint-Joseph | 90 | 2026-08-01 | 2026-06-02 |
| Early Norepinephrine in Trauma Patients With Hemorrhagic Shock Norepinephrine, Placebo - Trauma, Multiple | Phase 1 / Phase 2 | Enrolling by invitation | Visarat Palitnonkiat | 40 | 2025-05-20 | 2025-05-18 |
| The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock Norepinephrine, Ringer's Lactate - Septic Shock, Sepsis | Phase 2 / Phase 3 | Completed | Universitas Indonesia | 42 | 2024-03-25 | 2024-06-20 |
| Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia Noradrenalin, Phenylephrine - Hypotension | Phase 2 / Phase 3 | Recruiting | University of Aarhus | 32 | 2023-12-20 | 2026-03-19 |
| the Effect of Oral Vasopressors for Liberation From IV Vasopressors in Spinal Shock Midodrine Oral Tablet, Minirin oral tablet, Nor-Adrenaline - Spinal Shock | Phase 2 | Unknown | Ahmed talaat ahmed aly | 90 | 2020-10-15 | 2020-10-14 |
| The Phenylephrine vs. Norepinephrine Infusion Undergoing Cesarean Section Norepinephrine, Phenylephrine, Ringer's Solution - Cesarean Section Complications | Phase 2 / Phase 3 | Completed | China International Neuroscience Institution | 238 | 2019-02-20 | 2020-02-10 |
| Vasopressin or Norepinephrine in Vasoplegic Shock After Non-cardiac Surgery Vasopressin, Norepinephrine - Circulatory Shock, Non-cardiac Surgery | Phase 2 / Phase 3 | Withdrawn | University of Sao Paulo | 2019-01-01 | 2023-10-05 | |
| Norepinephrine or Phenylephrine in Bolus for Hypotension in Cesarean Delivery Phenylephrine 100 mcg, Norepinephrine 5 mcg - Hypotension, Spinal Anesthesia | Phase 2 | Completed | Hospital dos Servidores do Estado do Rio de Janeiro | 72 | 2018-10-01 | 2021-04-13 |
| The Effect of Norepinephrine Versus Dopamine in Renal Transplant Recipients on Postoperative Graft Function Norepinephrine, Dopamine - Renal Transplant | Phase 2 / Phase 3 | Unknown | Assiut University | 44 | 2017-11-01 | 2017-10-20 |
| Phenylephrine and Noradrenaline for Post Spinal Anesthesia Hypotension phenylephrine, Norepinephrine, Bupivacaine - Adverse Anesthesia Outcome | Phase 2 | Completed | Kasr El Aini Hospital | 200 | 2017-01-01 | 2017-05-03 |
| Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly Hemodynamic target, Phenylephrine, Intravenous fluids - Post-operative Cognitive Dysfunction | Phase 2 / Phase 3 | Suspended | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 1812 | 2014-10-01 | 2018-04-13 |
| Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury Norepinephrine, Dobutamine and norepinephrine - Severe Traumatic Brain Injury With High Cerebral Pressure | Phase 2 | Unknown | University Hospital, Grenoble | 20 | 2014-10-01 | 2015-08-17 |
| Exploratory Study of Topical Norepinephrine in Breast Cancer Patients Receiving Radiotherapy Norepinephrine - Radiodermatitis | Phase 1 / Phase 2 | Withdrawn | ProCertus BioPharm, Inc | 2012-03-01 | 2012-05-28 | |
| Hemodynamics and Extravascular Lung Water in Acute Lung Injury Diuresis (furosemide) part I, Fluid Bolus (crystalloid or albumin), Vasopressors (Norepinephrine, Vasopressin, Phenylephrine, Epinephrine) - Acute Lung Injury | Phase 2 | Completed | Oregon Health and Science University | 33 | 2008-02-01 | 2019-09-10 |
| Phenylephrine in Septic Shock Phenylephrine, Norepinephrine - Septic Shock | Phase 2 | Completed | University of Roma La Sapienza | 32 | 2007-11-01 | 2017-10-26 |
| Continuous Infusion of Terlipressin in Septic Shock Terlipressin, Vasopressin, Norepinephrine - Septic Shock | Phase 2 | Completed | University of Roma La Sapienza | 45 | 2007-01-01 | 2008-02-29 |
| Dopexamine and Norepinephrine Compared With Epinephrine Alone in Septic Shock Dopexamine and norepinephrine, Epinephrine - Septic Shock | Phase 2 | Completed | Rennes University Hospital | 20 | 2002-03-01 | 2006-01-02 |
| Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock norepinephrine and dobutamine, epinephrine plus placebo of dobutamine - Septic Shock, Severe Sepsis | Phase 2 / Phase 3 | Completed | University of Versailles | 330 | 1999-10-01 | 2010-07-22 |
Shock, Septic (5) · Sepsis (4) · Diabetes Insipidus (2) · Hypotension (2) · Acute Lung Injury (1) · Cognitive Dysfunction (1) · Delirium (1) · Hypertension, Pulmonary (1) · Infections (1) · Multiple Trauma (1) · Pulmonary Edema (1) · Radiodermatitis (1) · Respiratory Distress Syndrome (1) · Shock (1) · Wounds and Injuries (1)
University of Roma La Sapienza (2) · Ahmed talaat ahmed aly (1) · Assiut University (1) · China International Neuroscience Institution (1) · Fondation Hôpital Saint-Joseph (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Hospital dos Servidores do Estado do Rio de Janeiro (1) · Kasr El Aini Hospital (1) · Oregon Health and Science University (1) · ProCertus BioPharm, Inc (1) · Rennes University Hospital (1) · Universitas Indonesia (1) · University Hospital, Grenoble (1) · University of Aarhus (1) · University of Sao Paulo (1)
France (4) · Italy (3) · Egypt (2) · United States (2) · Brazil (1) · China (1) · Denmark (1) · Indonesia (1) · Thailand (1)
Eric Bellissant, MD, PhD (2) · Ahmed T Ahmed, lecture (1) · Alessandro Santini, MD (1) · Andrea Morelli, M.D. (1) · Andrea Morelli, MD (1) · Antonio Pesenti, MD (1) · Charles Phillips, M.D. (1) · Djillali Annane, MD, PhD (1) · Eleanor Harris, MD (1) · Juliano P Almeida, MD, PhD (1) · Luciano Gattinoni, MD, FRCP (1) · Mads Rasmussen, MD, PhD (1) · Michael Quintel, MD, PhD (1) · Philippe Seguin, MD (1)
PMID 16507156, PMID 16616623, PMID 17720019, PMID 19017409, PMID 19534818, PMID 19664253, PMID 21615299, PMID 25407570, PMID 27841822, PMID 28367008, PMID 30243062, PMID 32894044, PMID 36507525, PMID 40132839, PMID 9403749
2025 (1)