12 completed, 4 unknown, 3 recruiting, 2 not yet recruiting. 20 Not applicable, 4 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 20 | Completed 9, Unknown 4, Recruiting 3, Not yet recruiting 2, Active not recruiting 1, Terminated 1 |
| Phase 2 | 4 | Completed 3, Terminated 1 |
| Phase 1 | 2 | Completed 2 |
Follow Non-invasive brain stimulation: new trials by email Literature Review of Non-invasive brain stimulation trials Research Report on Non-invasive brain stimulation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue Transcranial Direct Current Stimulation - Long COVID, Post-COVID Conditions | Not applicable | Not yet recruiting | University of Las Palmas de Gran Canaria | 20 | 2026-09-15 | 2026-07-22 |
| Using Non-invasive Brain Stimulation to Explore Potential Treatments to Reduce Speech Errors in Adults Who Stutter High - Definition Transcranial Direct Current Stimulation - Stuttering, Fluency Disorder | Not applicable | Recruiting | The University of Texas at Dallas | 50 | 2026-03-17 | 2026-10-26 |
| The Efficacy of Non-invasive Brain Stimulation (NIBS) on Cognitive Functions in Patients With Chronic Obstructive Pulmonary Disease (COPD) Non-invasive brain stimulation, Sham Non-Invasive brain stimulation - COPD, COPD (Chronic Obstructive Pulmonary Disease) | Not applicable | Active not recruiting | Ministry of Health, Kuwait | 22 | 2026-01-20 | 2026-10-20 |
| Brain Stimulation in Long COVID Repetitive Transcranial Magnetic Stimulation, Sham device - Long COVID, PASC Post Acute Sequelae of COVID 19 | Not applicable | Recruiting | Amsterdam UMC, location VUmc | 66 | 2025-11-17 | 2025-12-19 |
| Closed-loop rTMS-EEG During Visuomotor Integration. repetitive transcranial magnetic stimulation (rTMS) - Visuomotor Skills, Brain Lesion (General) | Not applicable | Recruiting | Medical University of South Carolina | 20 | 2025-11-01 | 2026-09-15 |
| The Effects of tDCS Combined With rTMS on Post-stroke Cognitive Impairment routine treatment, Non-invasive brain stimulation - Stroke | Not applicable | Unknown | The Second Affiliated Hospital of Dalian Medical University | 60 | 2023-11-01 | 2024-02-12 |
| Non-invasive Brain Stimulation and Strategic Memory Training Non-invasive brain stimulation, Sham non-invasive brain stimulation - Cognitive Decline, Healthy Aging | Not applicable | Not yet recruiting | IRCCS National Neurological Institute "C. Mondino" Foundation | 56 | 2023-07-30 | 2023-07-03 |
| Modulating Prospective Memory in Older Adults With Non-invasive Brain Stimulation Non-invasive brain stimulation, Sham stimulation - Healthy Aging | Not applicable | Completed | University of Bern | 106 | 2021-06-28 | 2023-12-12 |
| IMPULSE - StIMulation of Brain Plasticity to Improve Upper Limb Recovery After StrokE Cerebrolysin, non-invasive brain stimulation, Placebo - Chronic Stroke, Subacute Stroke | Phase 2 | Terminated | Ever Neuro Pharma GmbH | 4 | 2021-06-25 | 2022-07-28 |
| Gamma-Induction in FrontoTemporal Dementia Trial Transcranial Alternating Current Stimulation (tACS), Sham Transcranial Alternating Current Stimulation (sham tACS) - Frontotemporal Dementia | Not applicable | Unknown | Massachusetts General Hospital | 70 | 2020-12-30 | 2024-09-26 |
| Cognitive Improvement Through tDCS for Patients With Multiple Sclerosis Active transcranial direct current stimulation, Sham transcranial direct current stimulation - Multiple Sclerosis | Not applicable | Unknown | University Medicine Greifswald | 30 | 2020-12-08 | 2023-05-15 |
| Home-based Brain Stimulation for Memory Transcranial alternating current stimulation (tACS) - Alzheimer Disease, Memory Loss | Not applicable | Completed | Hebrew SeniorLife | 20 | 2020-07-06 | 2024-06-25 |
| Memory Functions in Mild Alzheimer's Disease transcranial alternating current stimulation (tACS) - Alzheimer Disease | Not applicable | Completed | Hebrew SeniorLife | 34 | 2020-06-22 | 2024-06-26 |
| Gamma Induction for Alzheimer's Disease Transcranial Alternating Current Stimulation (tACS), Sham Transcranial Alternating Current Stimulation - Alzheimer Disease, Mild Cognitive Impairment | Phase 1 / Phase 2 | Completed | Massachusetts General Hospital | 17 | 2019-08-05 | 2026-03-11 |
| tDCS in Pediatric Acquired Brain Injury tDCS - Acquired Brain Injury, Disorders of Consciousness | Not applicable | Terminated | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 1 | 2019-08-01 | 2024-02-02 |
| Enhancing Sleep Dependent Consolidation by Non-invasive Brain Stimulation Non-invasive brain stimulation - Stroke, Aging | Not applicable | Completed | Friedhelm Hummel | 62 | 2019-03-20 | 2023-05-06 |
| Effect of Modulating Gamma Oscillations Using tACS Transcranial Alternating Current Stimulation (tACS) - Alzheimer Disease | Not applicable | Completed | Massachusetts General Hospital | 5 | 2018-08-02 | 2022-08-22 |
| Cathodal tDCS in MCI: A Randomized, Double-Blind, Sham-Controlled Pilot Study Soterix Medical 1x1 Low Intensity Transcranial Electrical Stimulator (tES) Model 2001 - Mild Cognitive Impairment, Cognitive Impairment | Not applicable | Completed | Mayo Clinic | 16 | 2018-02-20 | 2020-03-25 |
| Cognitive Abilities in Brain Damaged Patients Cognitive evaluation, Non-invasive brain stimulation - Brain Damage | Not applicable | Unknown | Neuromed IRCCS | 100 | 2017-12-15 | 2022-10-31 |
| Non-invasive Stimulation in Neurofibromatosis Type 1 Transcranial direct current stimulation - Neurofibromatosis 1 | Not applicable | Completed | University of Manchester | 16 | 2017-10-13 | 2019-04-24 |
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Cognitive Dysfunction (5) · Alzheimer Disease (4) · Stroke (3) · Brain Injuries (2) · Post-Acute COVID-19 Syndrome (2) · Alcoholism (1) · Behavior, Addictive (1) · Brain Infarction (1) · Brain Ischemia (1) · Central Nervous System Diseases (1) · Cerebrovascular Disorders (1) · Cocaine-Related Disorders (1) · Cognition Disorders (1) · Consciousness Disorders (1) · Fatigue (1)
Massachusetts General Hospital (3) · Federal University of Espirito Santo (2) · Hebrew SeniorLife (2) · Amsterdam UMC, location VUmc (1) · Beth Israel Deaconess Medical Center (1) · Ever Neuro Pharma GmbH (1) · Friedhelm Hummel (1) · Hugo W. Moser Research Institute at Kennedy Krieger, Inc. (1) · IRCCS National Neurological Institute "C. Mondino" Foundation (1) · King's College London (1) · Mayo Clinic (1) · Medical University of South Carolina (1) · Ministry of Health, Kuwait (1) · Neuromed IRCCS (1) · The Second Affiliated Hospital of Dalian Medical University (1)
United States (10) · Brazil (2) · Italy (2) · Switzerland (2) · Austria (1) · China (1) · Germany (1) · Netherlands (1) · Saudi Arabia (1) · United Kingdom (1)
Emiliano Santarnecchi, PhD (3) · Alvaro Pascual-Leone, Dr. (2) · Ester M Nakamura-Palacios, MD, PhD (2) · Andreas Winkler, MD, MSc (1) · Diego Centonze, MD (1) · Gottfried Schlaug, MD, PhD (1) · Jessica Peter, PD Dr. (1) · Juan Francisco Vigueras, MD (1) · Kirstin-Friederike Heise, Ph.D. (1) · Marcus Meinzer, Prof., PhD (1) · Matthias Kliegel, Prof. Dr. (1) · Nadine Schmidt, MSc. (1)
PMID 24345389, PMID 30902640, PMID 10945804, PMID 12784889, PMID 19007738, PMID 21068427, PMID 24139147, PMID 25797650, PMID 26648859, PMID 28709880, PMID 30720478, PMID 31277878, PMID 31401607, PMID 31739167, PMID 32265551, PMID 34930421, PMID 37333833, PMID 37549139, PMID 37608248, PMID 37732853, PMID 40574976, PMID 9153480
2017 (1), 2019 (1), P50HD118628 (1), R01AG060981 (1), R01NS045049 (1)