13 completed, 3 terminated, 3 withdrawn, 2 recruiting. 24 Phase 2, 3 Phase 3, 1 Phase 1.
Follow Nitrous Oxide: new trials by email Literature Review of Nitrous Oxide trials Research Report on Nitrous Oxide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of EMONO as an add-on Therapy to Conventional Antidepressants for the Treatment of Depressive Symptoms in Nursing-home Residents With Neurocognitive Disorders: a Randomized Controlled Trial- EMONO, Medical air - Depression, Neurocognitive Disorders | Phase 2 | Not yet recruiting | University Hospital, Tours | 96 | 2026-09-01 | 2026-06-17 |
| N2O for Acute Suicidality and Depression in the ED Nitrous oxide gas for inhalation, Placebo - Suicidal Ideation, Major Depressive Disorder | Phase 2 | Withdrawn | University of Chicago | 2026-02-27 | 2026-03-04 | |
| Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide Nitrous oxide, Medical air - Suicidal Ideation, Emergency Psychiatric | Phase 2 | Unknown | University Hospital, Tours | 30 | 2024-06-01 | 2024-06-07 |
| Effect of Nitrous Oxide on Aggression. Nitrous oxide, Room Air - Intermittent Explosive Disorder | Phase 2 | Recruiting | Ohio State University | 50 | 2022-09-06 | 2025-03-27 |
| Nitrous Oxide as Treatment for Fibromyalgia Nitrous oxide gas for inhalation, Placebo - Fibromyalgia, Central Neuropathic Pain | Phase 2 | Withdrawn | University of Chicago | 2021-11-12 | 2026-05-14 | |
| Nitrous Oxide for PTSD Nitrous Oxide, Midazolam, Nitrogen - PTSD | Phase 2 | Terminated | VA Office of Research and Development | 1 | 2021-10-07 | 2023-03-03 |
| Antidepressant Effects of Nitrous Oxide Nitrous oxide gas for inhalation, Placebo - Major Depressive Disorder, Treatment Resistant Depression | Phase 2 | Withdrawn | University of Chicago | 2021-06-30 | 2026-05-14 | |
| Efficacy of Nitrous Oxide in OCD: Pilot Study Nitrous Oxide, Nitrogen - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Stanford University | 45 | 2021-04-17 | 2025-08-27 |
| Nitrous Oxide for Major Depressive Disorder Nitrous Oxide, Placebo - Depressive Disorder, Major Depressive Disorder | Phase 2 | Completed | Lingjiang Li | 44 | 2019-04-01 | 2021-04-08 |
| Nitrous Oxide for the Treatment of Major Depressive Disorder Nitrous Oxide, Placebo - Depression, Major Depressive Disorder | Phase 2 | Completed | Bayside Health | 81 | 2019-01-22 | 2024-12-16 |
| TIVA vs Inhalational Mode of Anaesthesia Injection dexmedetomidine, Injection, Propofol, 10 Mg, sevoflurane - Anesthesia Awareness | Phase 2 | Completed | Rajiv Gandhi Cancer Institute & Research Center, India | 100 | 2019-01-10 | 2020-02-19 |
| Exploring Nitrous Oxide Effects for Post Traumatic Stress Disorder (PTSD) Nitrous Oxide - Post Traumatic Stress Disorder | Phase 2 | Completed | Stanford University | 3 | 2018-04-01 | 2020-07-24 |
| CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery) Epidural delivery system, Entonox, Meperidine - Depression, Postpartum, Analgesia, Obstetrical | Phase 2 / Phase 3 | Active not recruiting | KK Women's and Children's Hospital | 881 | 2017-06-15 | 2026-08-06 |
| Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies Nitrous Oxide 25%, Nitrous Oxide 50%, Placebo Gas - Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant | Phase 2 | Completed | Washington University School of Medicine | 24 | 2016-11-22 | 2022-04-04 |
| EMONO for the Treatment of Peripheral Neuropathic Pain Medical Air, EMONO - Neuralgia | Phase 2 | Completed | Air Liquide Santé International | 287 | 2016-11-01 | 2018-09-21 |
| Mixture Nitrous Oxide - Oxygen 50-50% in Transrectal Prostate Biopsy Guided by Ultrasound Nitrous Oxide NO, O2 - Anesthesia | Phase 1 / Phase 2 | Completed | Universidade Federal Fluminense | 84 | 2016-04-01 | 2018-05-09 |
| Nitrous Oxide as a Putative Novel Dual-Mechanism Treatment for Bipolar Disorder Nitrous Oxide, Midazolam - Bipolar Disorder | Phase 2 | Terminated | Sunnybrook Health Sciences Centre | 25 | 2015-08-01 | 2023-04-06 |
| Efficacy of Premixed Nitrous Oxide and Oxygen in Elderly Patient With Out-of-hospital Severe Acute Pain Premixed 50% nitrous oxide and oxygen, Medical Air - Pain Acute | Phase 2 / Phase 3 | Terminated | University Hospital, Toulouse | 43 | 2013-07-01 | 2018-02-05 |
| Nitrous Oxide as Treatment for Major Depression - a Pilot Study Nitrous Oxide, Placebo - Depression, Major Depressive Disorder | Phase 2 | Completed | Washington University School of Medicine | 21 | 2012-11-01 | 2020-01-27 |
| Analgesic Effect of IV Acetaminophen in Tonsillectomies Acetaminophen (paracetamol), Normal Saline Flush, Midazolam - Adenotonsillitis, Tonsillitis | Phase 2 | Completed | Nationwide Children's Hospital | 250 | 2012-10-01 | 2017-04-06 |
Showing 20 of 24. Sign in to see all of them.
Depression (7) · Depressive Disorder, Major (6) · Depressive Disorder, Treatment-Resistant (4) · Opioid-Related Disorders (3) · Substance-Related Disorders (3) · Agnosia (2) · Stress Disorders, Post-Traumatic (2) · Suicidal Ideation (2) · Acute Pain (1) · Alcohol-Related Disorders (1) · Bipolar Disorder (1) · Depression, Postpartum (1) · Depressive Disorder (1) · Disruptive, Impulse Control, and Conduct Disorders (1) · Fibromyalgia (1)
University of Chicago (6) · Stanford University (2) · University Hospital, Tours (2) · Washington University School of Medicine (2) · Air Liquide Santé International (1) · Baxter Healthcare Corporation (1) · Bayside Health (1) · KK Women's and Children's Hospital (1) · Lingjiang Li (1) · Nationwide Children's Hospital (1) · Ohio State University (1) · Rajiv Gandhi Cancer Institute & Research Center, India (1) · Sunnybrook Health Sciences Centre (1) · Universidade Federal Fluminense (1) · University Hospital, Toulouse (1)
United States (14) · France (3) · Australia (2) · Brazil (1) · Canada (1) · China (1) · Germany (1) · India (1) · Japan (1) · Reunion (1) · Singapore (1)
Peter Nagele, MD, MSc (4) · James Zacny, Ph.D. (3) · Paul Myles, MD (2) · Arlyne Thung, MD (1) · Ban Leong Sng, FANZCA (1) · Ben Palanca, MD (1) · Benjamin I Goldstein, MD (1) · Carolyn I Rodriguez, MD PhD (1) · Carolyn Rodriguez, MD, PhD (1) · Didier Bouhassira, MD (1) · Emil Coccaro, M.D. (1) · Lingjiang Li, MD (1)
PMID 37585253, PMID 32609959, PMID 32637725, PMID 33044394, PMID 35050957, PMID 36579458, PMID 37491196, PMID 37990597, PMID 39732915, PMID 40113655, PMID 42049811, PMID 42092800, PMID 42314868
R01DA008391 (3), 2023 (1), I01CX001789 (1)