23 completed, 5 recruiting, 2 unknown, 1 active not recruiting. 18 Not applicable, 7 Phase 4, 5 Phase 2, 3 Phase 1, 3 Phase 3.
Follow Nicotine Replacement Therapy (NRT): new trials by email Literature Review of Nicotine Replacement Therapy (NRT) trials Research Report on Nicotine Replacement Therapy (NRT)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT) - Tobacco Use Cessation, Tobacco Use Disorder | Not applicable | Not yet recruiting | University of Virginia | 120 | 2026-09-01 | 2026-07-10 |
| Smart Olfaction App to Reduce Relapse Ad Libitum Use followed by Instructed Use of the Inspire Device, Instructed Use followed by Ad Libitum Use of the Inspire Device, Smart-T Smoking Cessation App with the Inspire Device Condition - Nicotine Dependence | Early Phase 1 | Recruiting | University of Houston | 132 | 2026-04-22 | 2026-07-08 |
| Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness Nicotine Replacement Therapy (NRT), Wellness Coaching - Tobacco Cessation, Tobacco Abstinence | Phase 4 | Recruiting | University of California, San Francisco | 150 | 2025-11-14 | 2025-11-21 |
| Cytisine vs Nicotine Replacement Therapy Cytisine, Nicotine replacement therapy (NRT) - Tobacco Dependence, COPD Asthma | Not applicable | Enrolling by invitation | Ottawa Hospital Research Institute | 200 | 2025-11-04 | 2026-03-17 |
| E-cigarette Harm Reduction Among PLWHA in South Africa Nicotine Replacement Therapy (NRT), E-Cigarette (EC), Counseling - Tobacco Smoking | Phase 1 | Completed | NYU Langone Health | 106 | 2025-04-15 | 2026-06-09 |
| Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy Electronic Cigarettes (EC), Nicotine replacement therapy (NRT) - Smoking Cessation, Obesity and Obesity-related Medical Conditions | Not applicable | Recruiting | Brown University | 60 | 2025-04-01 | 2026-05-18 |
| The "Quit-for-Kids" Project: to Increase Abstinence and Protect Children From Tobacco Smoke Exposure Brief cessation advice (AWARD), Nicotine Replacement Therapy (NRT), Instant messaging Support (IM) - Smoking Cessation, Second Hand Tobacco Smoke | Not applicable | Recruiting | The University of Hong Kong | 1200 | 2024-02-05 | 2026-05-04 |
| E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling - Cigarette Smoking | Not applicable | Recruiting | NYU Langone Health | 60 | 2023-11-13 | 2026-09-29 |
| Integrating Tobacco Use Cessation Into HIV Care and Treatment in Kisumu County, Kenya Tobacco Use Cessation Counselling Sessions, Bupropion, Nicotine patch - Tobacco Use Cessation, Tobacco Use | Phase 4 | Completed | University of California, San Francisco | 580 | 2023-05-16 | 2025-07-02 |
| Comparative Effectiveness of Cystine Versus Nicotine Replacement Therapy Cytisine, Nicotine Replacement Therapy (NRT) - Nicotine Addiction | Phase 4 | Completed | Loma Linda University | 1307 | 2022-01-27 | 2024-09-19 |
| Evaluating Smoking Cessation Protocols in Cancer Patients: NRT, MI, CBT or Hypnotherapy Motivational Interviewing (MI), Cognitive Behavioural Therapy (CBT), Hypnotherapy - Breast Cancer, Gynecologic Cancer | Not applicable | Terminated | Institut Cancerologie de l'Ouest | 21 | 2021-09-29 | 2026-08-07 |
| STARS (Smoking Treatment And Remote Sampling) Study Varenicline 0.5 MG, Nicotine Replacement Therapy (NRT) - Smoking, Smoking Cessation | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 652 | 2021-02-08 | 2026-02-17 |
| Electronic Cigarettes as a Harm Reduction Strategy Among Patients With COPD E-cigarette (EC), Nicotine Replacement Therapy (NRT), Smoking Harm Reduction Counseling Sessions - COPD | Not applicable | Completed | NYU Langone Health | 146 | 2020-11-09 | 2023-06-15 |
| Heart Rate Variability Biofeedback for Smoking Cessation Cognitive-Behavioral Smoking Cessation, Heart Rate Variability Biofeedback (HRVB), Transdermal Nicotine patch - Tobacco Smoking | Phase 2 | Completed | Rutgers, The State University of New Jersey | 10 | 2019-04-24 | 2020-08-25 |
| Preventing Smoking Relapse After Total Joint Replacement Surgery Comprehensive Relapse Prevention Intervention, Standard Treatment Counseling, Nicotine Replacement Therapy (NRT) - Smoking, Smoking Cessation | Not applicable | Completed | NYU Langone Health | 21 | 2019-01-15 | 2021-11-12 |
| Innovations to Prevent Relapse Among Low-income African American Smokers Nicotine replacement therapy (NRT), CS-CBT intervention, Path2Quit - Smoking Cessation | Not applicable | Completed | Case Comprehensive Cancer Center | 18 | 2019-01-01 | 2021-11-04 |
| Nicotine Patch as an Adjunctive Intervention to Reduce Secondhand Smoke Among NICU Families nicotine replacement therapy (NRT), motivational advice, Quitline referral - Environmental Tobacco Smoke, Smoking Cessation | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 32 | 2017-10-29 | 2024-12-11 |
| Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites Motivational Interviewing (MI), Nicotine Replacement Therapy (NRT), Nicotine Lozenge - Smoking Cessation | Phase 4 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 807 | 2017-10-10 | 2026-11-03 |
| Integrating Financial Management Counseling and Smoking Cessation Counseling to Reduce Health and Economic Disparities in Low-Income Immigrants Integrated Smoking Cessation and Financial Counseling, Waitlist Integrated Smoking Cessation and Financial Counseling, Nicotine Replacement Therapy (NRT) - Smoking Cessation | Phase 4 | Completed | NYU Langone Health | 410 | 2017-09-22 | 2021-06-18 |
| Optimizing Tobacco Dependence Treatment in the Emergency Department Brief Negotiated Interview (BNI), Nicotine replacement therapy (NRT), CT Smokers Quitline (QL) - Tobacco Use Disorder | Phase 3 | Completed | Yale University | 1056 | 2017-02-13 | 2020-12-04 |
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Smoking Cessation (26) · Smoking (8) · Tobacco Use Disorder (8) · Tobacco Use Cessation (5) · Tobacco Smoking (3) · Tobacco Use (3) · Vaping (3) · Cigarette Smoking (2) · Harm Reduction (2) · Substance-Related Disorders (2) · Anthracosis (1) · Breast Neoplasms (1) · Cardiovascular Diseases (1) · Gastrointestinal Neoplasms (1) · Insulin Resistance (1)
NYU Langone Health (5) · Johns Hopkins University (2) · M.D. Anderson Cancer Center (2) · Medical University of South Carolina (2) · Ottawa Hospital Research Institute (2) · The University of Hong Kong (2) · University of California, San Francisco (2) · Brown University (1) · Case Comprehensive Cancer Center (1) · Evotec Neurosciences GmbH (1) · Institut Cancerologie de l'Ouest (1) · Loma Linda University (1) · Memorial Sloan Kettering Cancer Center (1) · Rutgers, The State University of New Jersey (1) · The University of Texas Health Science Center, Houston (1)
United States (23) · Canada (2) · China (1) · France (1) · Germany (1) · Kenya (1) · Mongolia (1) · South Africa (1)
Omar El-Shahawy (2) · Alla Radicke, MD (1) · Amanda L Graham, PhD (1) · Angela L Stotts, PhD (1) · Anne Joseph, MD (1) · Christian K Roberts, Ph.D (1) · Davaalkham Dambadarjaa, MD (1) · David Wetter, PhD, MS, BA (1) · Dawn Beaulieu, MD (1) · Drew Harris, MD (1) · Elizabeth Stevens, PhD, MPH (1) · Eric A Dedert, PhD (1) · Erin Rogers (1) · Hilary Tindle, MD (1) · Jamie Ostroff, PhD (1)
PMID 22123796, PMID 24075893, PMID 24716466, PMID 25361769, PMID 26931362, PMID 29287665, PMID 29878062, PMID 30664539, PMID 31363948, PMID 32614201, PMID 34323541, PMID 34991693, PMID 35018561, PMID 35932394, PMID 35978334, PMID 37142273, PMID 37335995, PMID 40442834, PMID 41331201, PMID 41805956, PMID 42101840
P20GM130414 (1), P30CA044579 (1), P60MD000503 (1), R01CA141527 (1), R01CA141613 (1), R01CA155489 (1), R01CA201873 (1), R01DA021619 (1), R01DA026823 (1), R34DA043751 (1), U01CA261620 (1), UL1TR000124 (1)