28 completed, 3 unknown, 2 terminated, 1 active not recruiting. 36 Phase 1, 9 Phase 2.
Follow Modafinil: new trials by email Literature Review of Modafinil trials Research Report on Modafinil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Modafinil to Improve Fatiguability Modafinil, Placebo - Cancer-related Cognitive Difficulties, Cancer-related Problem/Condition | Phase 1 / Phase 2 | Recruiting | Ottawa Hospital Research Institute | 40 | 2026-03-16 | 2026-07-27 |
| Reliability of Standardized IQ Testing Under Modafinil, Racetam-Class Compounds, Sleep Restriction and Daily Activity Modafinil, Oxiracetam, Pramiracetam - Healthy, Cognition | Phase 1 | Completed | Abdulraheem Mohamed Gouda | 70 | 2026-03-09 | 2026-10-01 |
| A Study of MK-6552 in Sleep Deprived Healthy Participants (MK-6552-003) MK-6552, MK-6552 placebo, Modafinil - Healthy, Narcolepsy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 18 | 2024-03-19 | 2024-10-01 |
| Psilocybin Therapy for Chronic Low Back Pain Psilocybin therapy with Zolpidem and Modafinil, Psilocybin therapy with Zolpidem, Psilocybin therapy with Modafinil - Chronic Low-back Pain | Phase 1 / Phase 2 | Completed | Joshua Woolley, MD, PhD | 40 | 2023-12-01 | 2026-11-04 |
| A Clinical Study of MK-6552 and Modafinil in Healthy Men (MK-6552-005) MK-6552, Modafinil - Healthy, Narcolepsy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 12 | 2023-09-20 | 2024-10-30 |
| Bioequivalence Study of Modafinil From Bravamax 200 mg Scored Tablets (Chemipharm Pharmaceutical Industries, Egypt) Versus Vigil 200 mg Tablets (Teva GmbH, Germany) Bravamax 200 mg (Modafinil), Vigil 200 mg (Modafinil) - Healthy | Phase 1 | Completed | Genuine Research Center, Egypt | 30 | 2022-11-15 | 2023-05-11 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of TAK-925 Study in Sleep-Deprived Healthy Adults TAK-925, TAK-925 Placebo, Modafinil - Healthy Volunteers | Phase 1 | Completed | Takeda | 20 | 2018-05-09 | 2021-03-26 |
| Touchscreen-based Cognitive Tests in Healthy Volunteers Ketamine 0.58, Ketamine 0.31, Modafinil - Cognitive Symptom, Schizophrenia | Phase 1 | Unknown | University of Eastern Finland | 16 | 2018-03-12 | 2018-10-16 |
| Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors losartan, dextromethorphan, caffeine - Advanced Solid Tumors, Metastatic Melanoma | Phase 1 | Completed | Pfizer | 56 | 2018-01-02 | 2024-09-27 |
| Effect of Armodafinil on Simulated Driving armodafinil, Placebo (for armodafinil) - Healthy Volunteers | Phase 1 | Completed | University of Florida | 12 | 2017-05-21 | 2018-12-31 |
| A Study of LY3154207 on Sleep in Healthy Male Participants LY3154207, Placebo, Modafinil - Healthy | Phase 1 | Completed | Eli Lilly and Company | 16 | 2015-11-01 | 2016-04-06 |
| Impact of THN102 on Attention, Wakefulness and Cognitive Performance During Total Sleep Deprivation Placebo, Modafinil, THN102 - Sleep Deprivation | Phase 1 | Completed | Theranexus | 20 | 2015-09-01 | 2017-06-09 |
| Complementary Combination Therapy for Cocaine Dependence Doxazosin, Modafinil, cocaine - Cocaine Dependence | Phase 1 | Completed | Baylor College of Medicine | 45 | 2015-08-01 | 2022-04-26 |
| Effect Of Modafinil And Pioglitazone On The Pharmacokinetics Of Palbociclib (PD-0332991) Palbociclib alone, Palbociclib plus Modafinil, Palbociclib plus pioglitazone - Healthy | Phase 1 | Completed | Pfizer | 14 | 2014-10-01 | 2015-02-20 |
| Pharmacokinetics and Pharmacodynamics (PK/PD) of CEP-26401 in Healthy Subjects CEP-26401, donepezil hydrochloride, modafinil - Cognitive Impairment | Phase 1 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 40 | 2013-08-01 | 2014-04-03 |
| Symptom Burden in Head and Neck Cancer Placebo, Armodafinil, Minocycline - Head And Neck Cancer | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 1 | 2013-03-01 | 2015-02-10 |
| Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Armodafinil in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy Armodafinil - Narcolepsy | Phase 1 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 40 | 2012-07-01 | 2021-11-09 |
| Effects of Donepezil and Memantine on Cognitive Functions After a Sleep Deprivation Challenge in Healthy Volunteers Modafinil, Donepezil, Memantine - Healthy | Phase 1 | Completed | Qualissima | 36 | 2011-11-01 | 2015-02-04 |
| Single Agent Armodafinil for Patient-Reported Fatigue Following Radiation Therapy for Head and Neck Cancer Armodafinil, Placebo, Questionnaires - Head And Neck Cancer, Fatigue | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 26 | 2011-05-19 | 2024-02-14 |
| Modafinil - Escitalopram Study for Cocaine Dependence Modafinil and Escitalopram, Placebo, Modafinil - Cocaine Dependence, Cocaine Abuse | Phase 1 | Completed | Baylor College of Medicine | 68 | 2010-08-01 | 2012-05-18 |
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Cocaine-Related Disorders (4) · Fatigue (4) · Narcolepsy (3) · Schizophrenia (3) · Sleep Deprivation (3) · Cognitive Dysfunction (2) · Head and Neck Neoplasms (2) · cyclopia sequence (2) · Amphetamine-Related Disorders (1) · Brain Injuries, Traumatic (1) · Carcinoma (1) · Carcinoma, Non-Small-Cell Lung (1) · Chronic Pain (1) · Hypotension, Orthostatic (1) · Laryngeal Diseases (1)
M.D. Anderson Cancer Center (3) · Merck Sharp & Dohme LLC (3) · Baylor College of Medicine (2) · Mylan Pharmaceuticals Inc (2) · National Institute on Drug Abuse (NIDA) (2) · Pfizer (2) · Teva Branded Pharmaceutical Products R&D, Inc. (2) · Abdulraheem Mohamed Gouda (1) · Catherine Martin, MD (1) · Craig Hospital (1) · Eli Lilly and Company (1) · Genuine Research Center, Egypt (1) · Joshua Woolley, MD, PhD (1) · Laval University (1) · Massachusetts General Hospital (1)
United States (25) · Canada (3) · Finland (2) · Netherlands (2) · Belgium (1) · Egypt (1) · France (1) · Spain (1) · United Kingdom (1)
Thomas S Clark, M.D. (2) · Ahmed Elshafeey, Ph.D. Pharma (1) · Catherine Martin, PhD (1) · Christine Audebert (1) · David I. Rosenthal, MD, MA, BA (1) · Edward Fitzgibbon, MD, MSc, CCFP(PC) (1) · Fabien Sauvet, MD, PhD (1) · Gary B. Gunn, MD (1) · Hartmut Derendorf, PhD (1) · Italo Biaggioni, MD (1) · James Downar, MDCM, MHSc (1)
PMID 10662747, PMID 11904109, PMID 11927799, PMID 12119802, PMID 12832331, PMID 15066944, PMID 15710782, PMID 15738343, PMID 15911704, PMID 17515447, PMID 17515448, PMID 19687359, PMID 20837887, PMID 21035624, PMID 22311903, PMID 24002370, PMID 24122944, PMID 24227635, PMID 24495468, PMID 24606242, PMID 24721800, PMID 27148676, PMID 27271310, PMID 31419329, PMID 32673517, PMID 36934366, PMID 36999619, PMID 38424308, PMID 38878209, PMID 39727053, PMID 9727818
1RC1DA028387 (1), 2017 (1), 2019 (1), R01DA021264 (1), R03DA015413 (1), UL1TR000445 (1)