12 completed, 3 terminated, 2 active not recruiting, 2 recruiting. 21 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 21 | Completed 12, Terminated 3, Active not recruiting 2, Recruiting 2, Enrolling by invitation 1, Unknown 1 |
Follow Metoprolol Succinate: new trials by email Literature Review of Metoprolol Succinate trials Research Report on Metoprolol Succinate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score Metoprolol Succinate, Beta-Blocker Polygenic Score, Illumina Infinium Global Diversity Array with Enhanced Pharmacogenomics (PGx) - Heart Failure With Reduced Ejection Fraction | Phase 4 | Recruiting | University of Michigan | 100 | 2026-12-01 | 2026-10-15 |
| Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF) Placebo (matching), Beta-blockers - Heart Failure, HFpEF | Phase 4 | Enrolling by invitation | Weill Medical College of Cornell University | 240 | 2026-02-02 | 2026-10-16 |
| Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator Metoprolol Succinate, Carvedilol - Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death | Phase 4 | Recruiting | University of Rochester | 2000 | 2025-08-17 | 2025-09-18 |
| Beta-1 Adrenergic Inhibition to Reduce Cardiac Injury and Inflammation After Subarachnoid Hemorrhage (BADCATS) Metoprolol, Placebo - Non-Traumatic Subarachnoid Hemorrhage | Phase 4 | Active not recruiting | Madeleine Puissant | 20 | 2024-09-23 | 2026-10-19 |
| Medicine-induced Cardiac Hemodialysis on COVID-19 Nifedipine 30 MG, Kangzhu BPCB0A-3A, Low Mobility - Severe Acute Respiratory Syndrome-related Coronavirus, Renal Dialysis | Phase 4 | Completed | Yang I. Pachankis | 1 | 2023-01-02 | 2023-02-03 |
| BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in HFpEF Amlodipine Besylate, Metoprolol Succinate - Heart Failure With Preserved Ejection Fraction, Hypertension | Phase 4 | Completed | University of Pennsylvania | 50 | 2021-12-01 | 2026-01-30 |
| Impact of Beta-blockers on Physical Function in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2023-09-08 |
| Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2024-04-09 |
| Danish Trial of Beta Blocker Treatment After Myocardial Infarction Without Reduced Ejection Fraction Metoprolol Succinate, Bisoprolol, Carvedilol - Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction (nSTEMI) | Phase 4 | Active not recruiting | Bispebjerg Hospital | 2760 | 2018-12-17 | 2025-06-10 |
| Evaluation of Decreased Usage of Betablockers After Myocardial Infarction in the SWEDEHEART Registry (REDUCE-SWEDEHEART) Metoprolol Succinate, Bisoprolol - Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction | Phase 4 | Unknown | Karolinska Institutet | 5000 | 2017-09-11 | 2024-03-05 |
| Can Nebivolol Reverse Inappropriate Left Ventricular Mass in Hypertensive Patients? Nebivolol, Metoprolol succinate - Hypertension | Phase 4 | Terminated | Mayo Clinic | 1 | 2012-06-01 | 2014-05-19 |
| Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients Metoprolol succinate, Nebivolol, Non-invasive measurement of Cardiac Output (CO) - Hypertension | Phase 4 | Completed | University of Texas Southwestern Medical Center | 32 | 2010-08-01 | 2018-11-06 |
| Effect of Nebivolol on Oxidative Stress and Endothelial Progenitor Cells Nebivolol, Metoprolol succinate - Hypertension | Phase 4 | Completed | Emory University | 96 | 2009-12-01 | 2014-12-19 |
| Comparison of Nebivolol and Metoprolol With Exercise and Angiotensin II in Hypertensive Patients Metoprolol succinate, Nebivolol, Forearm blood flow - Hypertension | Phase 4 | Completed | University of Texas Southwestern Medical Center | 46 | 2009-04-01 | 2020-07-07 |
| Sympathetic Nervous System Modulation in Hypertension Metoprolol Succinate - Hypertension | Phase 4 | Terminated | University of Cincinnati | 24 | 2007-08-01 | 2018-02-07 |
| Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alone Captopril, Enalapril, Lisinopril - Heart Failure, Ventricular Dysfunction, Left | Phase 4 | Completed | AstraZeneca | 252 | 2006-10-01 | 2012-06-25 |
| Effects of Nebivolol Versus Metoprolol Succinate on Endothelial Function metoprolol succinate, Nebivolol - Hypertension | Phase 4 | Completed | Berlin-Chemie AG Menarini Group | 80 | 2006-03-01 | 2010-11-25 |
| Black Education and Treatment of Hypertension (BEAT HTN) Hydrochlorothiazide, Lisinopril, Lisinopril and Hydrochlorothiazide - Hypertension | Phase 4 | Completed | Creighton University | 99 | 2005-08-01 | 2012-12-04 |
| A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation. metoprolol succinate - Heart Valve Diseases | Phase 4 | Completed | Mayo Clinic | 60 | 2004-07-01 | 2008-07-24 |
| Telmisartan Effectiveness on Left Ventricular Mass Reduction (TELMAR) as Assessed by MRI, in Patients With Mild to Moderate Hypertension Telmisartan, Metoprolol succinate, Placebo - Hypertension | Phase 4 | Terminated | Boehringer Ingelheim | 24 | 2003-09-01 | 2014-09-17 |
Showing 20 of 21. Sign in to see all of them.
Hypertension (9) · Heart Failure (5) · Heart Diseases (2) · Heart Failure, Diastolic (2) · Non-ST Elevated Myocardial Infarction (2) · ST Elevation Myocardial Infarction (2) · Arrhythmias, Cardiac (1) · Cardiomyopathies (1) · Cardiomyopathy, Dilated (1) · Death, Sudden, Cardiac (1) · Genetic Risk Score (1) · Heart Valve Diseases (1) · Inflammation (1) · Severe Acute Respiratory Syndrome (1) · Ventricular Dysfunction (1)
Weill Medical College of Cornell University (3) · Mayo Clinic (2) · University of Texas Southwestern Medical Center (2) · AstraZeneca (1) · Berlin-Chemie AG Menarini Group (1) · Bispebjerg Hospital (1) · Boehringer Ingelheim (1) · Creighton University (1) · Emory University (1) · Karolinska Institutet (1) · Madeleine Puissant (1) · University of Cincinnati (1) · University of Colorado, Denver (1) · University of Michigan (1) · University of Pennsylvania (1)
United States (14) · Sweden (2) · China (1) · Denmark (1) · Estonia (1)
Parag Goyal, MD (2) · Wanpen Vongpatanasin, MD (2) · Andrew Ambrosy, MD, MPH (1) · Anna Meta D Kristensen, MD (1) · Arshed Quyyumi, MD (1) · Bertil Lindahl, MD PhD (1) · Bjorn Eriksson, MD (1) · Eva IB Prescott, MD, DMsC (1) · Hans Persson, MD, PhD (1) · Jaan Eha, Professor (1) · Jasmine Luzum, PharmD, PhD (1) · Madeleine Puissant, MD, PhD (1) · Marek Belohlavek, MD, PhD (1) · Maurice E Sarano, M.D. (1)
PMID 21536983, PMID 22708640, PMID 23547240, PMID 25637602, PMID 25681236, PMID 27199121, PMID 28138556, PMID 32446298, PMID 36526898, PMID 37265820, PMID 38587241, PMID 38717556, PMID 38733447, PMID 40888716, PMID 41286053, PMID 41934630, PMID 42137945
2018 (1), K76AG064428 (1), R01AG091005 (1), R01HL048013 (1), R01HL178410 (1)