25 completed, 8 terminated, 3 recruiting, 2 active not recruiting. 21 Phase 4, 10 Phase 3, 4 Not applicable, 2 Phase 1, 2 Phase 2.
Follow Metoprolol Succinate: new trials by email Literature Review of Metoprolol Succinate trials Research Report on Metoprolol Succinate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score Metoprolol Succinate, Beta-Blocker Polygenic Score, Illumina Infinium Global Diversity Array with Enhanced Pharmacogenomics (PGx) - Heart Failure With Reduced Ejection Fraction | Phase 4 | Recruiting | University of Michigan | 100 | 2026-12-01 | 2026-10-15 |
| Pharmacological Intervention to Prevent NOAF After TAVR Metoprolol succinate, Amiodarone - Atrial Fibrillation | Not applicable | Not yet recruiting | Shanghai East Hospital | 198 | 2026-04-07 | 2026-04-15 |
| Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF) Placebo (matching), Beta-blockers - Heart Failure, HFpEF | Phase 4 | Enrolling by invitation | Weill Medical College of Cornell University | 240 | 2026-02-02 | 2026-10-16 |
| Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator Metoprolol Succinate, Carvedilol - Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death | Phase 4 | Recruiting | University of Rochester | 2000 | 2025-08-17 | 2025-09-18 |
| Beta-1 Adrenergic Inhibition to Reduce Cardiac Injury and Inflammation After Subarachnoid Hemorrhage (BADCATS) Metoprolol, Placebo - Non-Traumatic Subarachnoid Hemorrhage | Phase 4 | Active not recruiting | Madeleine Puissant | 20 | 2024-09-23 | 2026-10-19 |
| CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes Metoprolol Succinate, Carvedilol - End-Stage Kidney Disease, End-Stage Renal Disease | Phase 3 | Recruiting | VA Office of Research and Development | 2540 | 2024-05-22 | 2026-10-13 |
| Medicine-induced Cardiac Hemodialysis on COVID-19 Nifedipine 30 MG, Kangzhu BPCB0A-3A, Low Mobility - Severe Acute Respiratory Syndrome-related Coronavirus, Renal Dialysis | Phase 4 | Completed | Yang I. Pachankis | 1 | 2023-01-02 | 2023-02-03 |
| Post-Acute Sequelae of Coronavirus-19 (COVID-19) With Dyspnea on Exertion And Associated TaChycardia TrEatment Study Metoprolol Succinate - Tachycardia, Dyspnea | Early Phase 1 | Terminated | Hackensack Meridian Health | 14 | 2022-03-23 | 2024-12-03 |
| Are Carvedilol and Metoprolol Succinate Comparable Treatments in Heart Failure Patients With Reduced Ejection Fraction Carvedilol, Metoprolol Succinate - Chronic Heart Failure | Not yet recruiting | Odense University Hospital | 5600 | 2022-01-03 | 2021-08-16 | |
| BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in HFpEF Amlodipine Besylate, Metoprolol Succinate - Heart Failure With Preserved Ejection Fraction, Hypertension | Phase 4 | Completed | University of Pennsylvania | 50 | 2021-12-01 | 2026-01-30 |
| The Efficacy and Safety of Metoprolol as add-on Treatment to Standard of Care in Preventing Cardiomyopathy in Patients With DMD Metoprolol Succinate, Placebo - Muscular Dystrophy, Duchenne | Phase 3 | Unknown | Medical University of Gdansk | 150 | 2021-08-18 | 2021-10-04 |
| Impact of Beta-blockers on Physical Function in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2023-09-08 |
| Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2024-04-09 |
| Danish Trial of Beta Blocker Treatment After Myocardial Infarction Without Reduced Ejection Fraction Metoprolol Succinate, Bisoprolol, Carvedilol - Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction (nSTEMI) | Phase 4 | Active not recruiting | Bispebjerg Hospital | 2760 | 2018-12-17 | 2025-06-10 |
| Evaluation of Metoprolol Pharmacokinetics in Patients Receiving Hi Flux Hemodialysis Metoprolol Succinate - Hemodialysis, Pharmacokinetics | Completed | University of Michigan | 8 | 2018-06-30 | 2019-07-29 | |
| The Effect of Metoprolol in Patients With Hypertrophic Obstructive Cardiomyopathy. Metoprolol Succinate, Placebo oral capsule - Hypertrophic Cardiomyopathy | Phase 2 | Completed | Steen Hvitfeldt Poulsen | 30 | 2018-05-01 | 2021-03-29 |
| Evaluation of Decreased Usage of Betablockers After Myocardial Infarction in the SWEDEHEART Registry (REDUCE-SWEDEHEART) Metoprolol Succinate, Bisoprolol - Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction | Phase 4 | Unknown | Karolinska Institutet | 5000 | 2017-09-11 | 2024-03-05 |
| Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Metoprolol succinate, Placebo - Pulmonary Disease, Chronic Obstructive | Phase 3 | Terminated | University of Minnesota | 532 | 2016-05-01 | 2021-01-25 |
| Pharmacogenetic Prediction of Metoprolol Effectiveness metoprolol succinate, Genotyping, CYP2D6 Phenotyping - Hypertension | Not applicable | Terminated | University of Colorado, Denver | 462 | 2014-09-01 | 2021-09-16 |
| Genetically Targeted Therapy for the Prevention of Symptomatic Atrial Fibrillation in Patients With Heart Failure bucindolol hydrochloride, metoprolol succinate, Placebo oral capsule - Current or Recent History of Atrial Fibrillation | Phase 2 | Completed | ARCA Biopharma, Inc. | 267 | 2014-04-01 | 2022-09-26 |
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Hypertension (18) · Heart Failure (7) · Heart Diseases (3) · Atrial Fibrillation (2) · Cardiomyopathies (2) · Cardiovascular Diseases (2) · Heart Failure, Diastolic (2) · Non-ST Elevated Myocardial Infarction (2) · ST Elevation Myocardial Infarction (2) · Arrhythmias, Cardiac (1) · Atrial Flutter (1) · COVID-19 (1) · Cardiomyopathy, Dilated (1) · Cardiomyopathy, Hypertrophic (1) · Death, Sudden, Cardiac (1)
AstraZeneca (4) · Weill Medical College of Cornell University (3) · Dr. Reddy's Laboratories Limited (2) · GlaxoSmithKline (2) · Mayo Clinic (2) · University of Colorado, Denver (2) · University of Michigan (2) · University of Texas Southwestern Medical Center (2) · ARCA Biopharma, Inc. (1) · Berlin-Chemie AG Menarini Group (1) · Bispebjerg Hospital (1) · Boehringer Ingelheim (1) · Brigham and Women's Hospital (1) · Creighton University (1) · East Coast Institute for Research (1)
United States (27) · Denmark (3) · Canada (2) · Dominican Republic (2) · India (2) · Poland (2) · Sweden (2) · Brazil (1) · China (1) · Estonia (1) · Hungary (1) · Netherlands (1) · Puerto Rico (1) · Serbia (1)
Dr. P. Vijaya Lakshmi, Clinical Investigator (2) · Parag Goyal, MD (2) · Wanpen Vongpatanasin, MD (2) · Andrew Ambrosy, MD, MPH (1) · Andrew Monte, MD (1) · Anna Meta D Kristensen, MD (1) · Areef Ishani, MD MS (1) · Arshed Quyyumi, MD (1) · Benjamin Epstein, PharmD (1) · Bertil Lindahl, MD PhD (1) · Bjorn Eriksson, MD (1) · Danielle Duffy, MD (1)
PMID 17236889, PMID 21306286, PMID 21536983, PMID 22708640, PMID 23547240, PMID 25637602, PMID 25681236, PMID 27199121, PMID 27267111, PMID 28138556, PMID 29754666, PMID 31633896, PMID 32160915, PMID 32446298, PMID 34270905, PMID 34915981, PMID 35363600, PMID 35450573, PMID 36526898, PMID 37265820, PMID 38419159, PMID 38587241, PMID 38717556, PMID 38733447, PMID 39570238, PMID 40888716, PMID 41286053, PMID 41934630, PMID 42137945
2018 (1), K23GM110516 (1), K76AG064428 (1), R01AG091005 (1), R01HL048013 (1), R01HL178410 (1)