26 completed, 6 unknown, 5 withdrawn, 4 recruiting. 46 Phase 2, 13 Phase 1, 9 Phase 3.
Follow Mannitol: new trials by email Literature Review of Mannitol trials Research Report on Mannitol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Dose-ranging Study of TTI-0102 in Adults and Children With Leigh Syndrome Spectrum (LSS) TTI-0102: cysteamine-pantetheine disulfide, D-Mannitol - Leigh Syndrome | Phase 2 | Not yet recruiting | Thiogenesis Therapeutics, Inc. | 18 | 2026-10-01 | 2026-07-24 |
| Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy Smart Ankle-Foot Orthosis, 5-Azacitidine, Placebo - Cerebral Palsy | Phase 2 | Recruiting | Shirley Ryan AbilityLab | 60 | 2026-05-28 | 2026-06-01 |
| tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy tSCS, 5-Azacitidine, Mannitol - Cerebral Palsy | Phase 2 | Recruiting | Shirley Ryan AbilityLab | 80 | 2026-05-28 | 2026-11-05 |
| Manipulating the Peri-Infarct Area Using Maraviroc to Enhance Motor Skills After Stroke Maraviroc, Mannitol - Ischemic Stroke, Stroke | Phase 2 | Recruiting | Emmanuel Carrera | 80 | 2025-07-14 | 2025-08-12 |
| Memantine as an Additive Therapy in Patients With Traumatic Brain Injury Memantine, Mannitol - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI) | Phase 2 / Phase 3 | Not yet recruiting | Mansoura University | 80 | 2025-03-25 | 2025-04-06 |
| A Dose-Image Optimization Trial Evaluating Mannitol and Voluven as Adjuncts for Indocyanine Green Voluven-assisted Indocyanine green fluorescence guided sentinel lymph node biopsy for breast cancer, Mannitol (20%) - Breast Cancer Early Stage Breast Cancer (Stage 1-3) | Phase 1 / Phase 2 | Enrolling by invitation | National Taiwan University Hospital | 30 | 2025-01-01 | 2025-04-16 |
| Adding Dexmedetomidine to Mannitol to Attenuate the Increase of Intracranial Pressure Dexmedetomidine with Mannitol, Mannitol (20%) - Dexmedetomidine | Phase 2 / Phase 3 | Completed | Cairo University | 60 | 2024-07-12 | 2026-01-21 |
| A Study to Select the Dose and Evaluate the Effectiveness and Safety of the Drug Refralon®, Tablets, 1 mg for Long-term Use to Prevent Recurrence of Atrial Fibrillation/Flutter After Terminating Its Persistent Form 4-Nitro-N-[(1RS)-1-(4-fluorophenyl)-2-(1-ethylpiperidin-4-yl)ethyl]benzamide hydrochloride, Mannitol - Atrial Fibrillation, Atrial Flutter | Phase 2 | Active not recruiting | National Medical Research Center for Cardiology, Ministry of Health of Russian Federation | 175 | 2024-06-03 | 2026-04-08 |
| A Study To Evaluate The Efficacy, Safety, Pharmacokinetics, And Pharmacodynamic Effects Of GDC-6599 In Patients With Chronic Cough GDC-6599, GDC-6599-matching placebo, Mannitol - Chronic Refractory Cough (CRC) With Non-atopic Asthma, CRC With Atopic Asthma | Phase 2 | Completed | Genentech, Inc. | 49 | 2023-03-22 | 2025-12-16 |
| Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy Sodium Thiosulfate + Mannitol - Ototoxic Hearing Loss | Phase 2 | Recruiting | Sunnybrook Health Sciences Centre | 92 | 2023-02-15 | 2023-04-14 |
| Assessment of the Efficacy of Calcium Dobesilate vs. Placebo on SARS-CoV-2 Viral Load Amongst Outpatients With COVID-19. Calcium Dobesilate, Mannitol - COVID-19 Virus Disease | Phase 2 | Completed | Hervé SPECHBACH | 74 | 2022-05-17 | 2024-02-28 |
| #StayHome: Early Hydroxychloroquine to Reduce Secondary Hospitalisation and Household Transmission in COVID-19 Hydroxychloroquine, Mannitol - COVID-19 | Phase 2 / Phase 3 | Withdrawn | Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland | 2022-01-01 | 2025-01-07 | |
| MAnnitol for Blood Pressure Stability in HemoDialysis (MAP-HD) Mannitol, 0.9% saline - Hemodialysis Complication, Hemodynamic Instability | Phase 2 / Phase 3 | Completed | Brigham and Women's Hospital | 31 | 2021-04-06 | 2025-11-24 |
| Effect of AD128 to Treat Obstructive Sleep Apnea AD128, Mannitol - Sleep Apnea, Obstructive | Phase 2 / Phase 3 | Completed | Raphael Heinzer | 15 | 2020-10-20 | 2021-08-06 |
| The Optimal Dose of Mannitol for Intraoperative Brain Relaxation During the Operation of Aneurysmal Subarachnoid Hemorrhage Mannitol - Aneurysmal Subarachnoid Hemorrhage | Phase 1 / Phase 2 | Unknown | Beijing Tiantan Hospital | 99 | 2019-04-20 | 2023-11-30 |
| The Effect of Intravenous Mannitol Plus Saline on the Prevention of Cisplatin-induced Nephrotoxicity: A Randomized, Double-blind, Placebo Controlled Trial Mannitol, Placebo - Cis-Platinum Nephropathy, Mannitol Adverse Reaction | Phase 2 / Phase 3 | Completed | Phramongkutklao College of Medicine and Hospital | 48 | 2018-12-01 | 2022-01-21 |
| Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy Mannitol, Menthol - Diabetic Peripheral Neuropathy | Phase 1 / Phase 2 | Completed | University of British Columbia | 72 | 2017-03-15 | 2021-03-02 |
| Low-dose Intra-arterial Bevacizumab for Edema and Radiation Necrosis Therapeutic Intervention (LIBERTI) 25% Mannitol, Low-dose Intra-arterial Bevacizumab - Radiation Necrosis | Phase 2 | Completed | Norton Healthcare | 10 | 2016-11-23 | 2022-05-24 |
| Influence of Triflusal on Cognitive Functions in Subjects Under Chronic Stress Triflusal, Placebo - Healthy | Phase 2 | Completed | Prof. Dominique de Quervain, MD | 41 | 2016-09-13 | 2017-03-01 |
| Nalmefene, Baclofen and Impulsivity in Subjects With Alcohol Use Disorder and Healthy Control Subjects Nalmefene, Baclofen, Placebo Oral Capsule - Alcohol Use Disorder | Phase 2 | Completed | Prof. Daniele Zullino | 37 | 2016-07-01 | 2020-10-29 |
Showing 20 of 46. Sign in to see all of them.
Brain Injuries, Traumatic (4) · Cystic Fibrosis (4) · Stroke (3) · Brain Edema (2) · COVID-19 (2) · Cerebral Palsy (2) · Craniocerebral Trauma (2) · Head Injuries, Closed (2) · Acute Kidney Injury (1) · Alcoholism (1) · Amyloidosis (1) · Arteriovenous Malformations (1) · Astrocytoma (1) · Atrial Fibrillation (1) · Atrial Flutter (1)
Syntara (5) · OHSU Knight Cancer Institute (3) · Prof. Dominique de Quervain, MD (3) · Brigham and Women's Hospital (2) · Cairo University (2) · Shirley Ryan AbilityLab (2) · University of British Columbia (2) · Abela Pharmaceuticals, Inc. (1) · Ain Shams University (1) · Beijing Tiantan Hospital (1) · Brigitte Jolles, MD (1) · Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland (1) · Emmanuel Carrera (1) · Florian Michel (1) · Genentech, Inc. (1)
United States (12) · Switzerland (9) · Canada (5) · Australia (3) · China (3) · United Kingdom (3) · Egypt (2) · Germany (2) · Argentina (1) · France (1) · Russia (1) · Taiwan (1) · Thailand (1)
Edward A Neuwelt (3) · Andrew Bush, FRCPCH (1) · Anne Munck, Dr (1) · Arun Jayaraman, PhD (1) · Blaise Genton, MD-PhD (1) · Brett Charlton, MBBS PhD (1) · Brian P Walcott, MD (1) · Brian V Nahed, MD (1) · Brigitte Brigitte (1) · Chirag R Parikh, MD, PhD (1) · Christiane De Boeck (1) · Clayton D Harro, MD (1)
PMID 17337677, PMID 18972410, PMID 19996349, PMID 22150036, PMID 25142813, PMID 26218852, PMID 31024734, PMID 31040088, PMID 33735508, PMID 35426830, PMID 36861433, PMID 37875429, PMID 38719313, PMID 41124168, PMID 42082248
2008 (1), 2015 (1), R01CA137488 (1), R01NS044687 (1)