17 completed, 4 terminated, 4 unknown, 2 recruiting. 31 Phase 3, 9 Phase 2.
Follow Mannitol: new trials by email Literature Review of Mannitol trials Research Report on Mannitol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Trial on Bowel Preparation Comparing Mannitol 100g to Plenvu Both in a Same Day Regimen (CLEARWAY) 100g of Mannitol, 1L PEG-Asc - Elective Colonoscopy | Phase 3 | Recruiting | NTC srl | 412 | 2025-09-02 | 2026-03-13 |
| Memantine as an Additive Therapy in Patients With Traumatic Brain Injury Memantine, Mannitol - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI) | Phase 2 / Phase 3 | Not yet recruiting | Mansoura University | 80 | 2025-03-25 | 2025-04-06 |
| Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma. Tezepelumab, Budesonide/formoterol, Albuterol/budesonide (AIRSUPRA®) - Severe Asthma | Phase 3 | Active not recruiting | AstraZeneca | 310 | 2024-09-30 | 2026-10-13 |
| Adding Dexmedetomidine to Mannitol to Attenuate the Increase of Intracranial Pressure Dexmedetomidine with Mannitol, Mannitol (20%) - Dexmedetomidine | Phase 2 / Phase 3 | Completed | Cairo University | 60 | 2024-07-12 | 2026-01-21 |
| The Effect of Mannitol Volume With Changes in Osmolarity in Traumatic Brain Injury Mannitol - Anesthesia, Traumatic Brain Injury | Phase 3 | Completed | Universitas Diponegoro | 64 | 2023-11-01 | 2026-06-11 |
| Retrograde Autologous Priming and Mannitol for Reducing Hemodilution in Cardiac Surgery Retrograde autologous priming, Mannitol, Conventional Priming - Hemodilution, Coronary Artery Disease | Phase 3 | Withdrawn | Hamilton Health Sciences Corporation | 2022-09-21 | 2023-02-28 | |
| #StayHome: Early Hydroxychloroquine to Reduce Secondary Hospitalisation and Household Transmission in COVID-19 Hydroxychloroquine, Mannitol - COVID-19 | Phase 2 / Phase 3 | Withdrawn | Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland | 2022-01-01 | 2025-01-07 | |
| MAnnitol for Blood Pressure Stability in HemoDialysis (MAP-HD) Mannitol, 0.9% saline - Hemodialysis Complication, Hemodynamic Instability | Phase 2 / Phase 3 | Completed | Brigham and Women's Hospital | 31 | 2021-04-06 | 2025-11-24 |
| Effect of AD128 to Treat Obstructive Sleep Apnea AD128, Mannitol - Sleep Apnea, Obstructive | Phase 2 / Phase 3 | Completed | Raphael Heinzer | 15 | 2020-10-20 | 2021-08-06 |
| Sodium Lactate and Brain Relaxation (LSD) Sodium Lactate, Mannitol 20% Infusion - Sodium Lactate, Intracranial Hypertension | Phase 3 | Completed | Centre Hospitalier Universitaire de Besancon | 50 | 2020-09-29 | 2023-09-13 |
| Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass Allopurinol, Mannitol - Congenital Heart Disease in Children, Neuroprotection | Phase 3 | Recruiting | dr. M.J.N.L. Benders | 236 | 2020-02-14 | 2024-05-16 |
| The Effect of Intravenous Mannitol Plus Saline on the Prevention of Cisplatin-induced Nephrotoxicity: A Randomized, Double-blind, Placebo Controlled Trial Mannitol, Placebo - Cis-Platinum Nephropathy, Mannitol Adverse Reaction | Phase 2 / Phase 3 | Completed | Phramongkutklao College of Medicine and Hospital | 48 | 2018-12-01 | 2022-01-21 |
| The Effect of Deep Inhalation on Mannitol Responsiveness Deep inhalation technique, Tidal breathing technique, Methacholine - Asthma | Phase 3 | Completed | University of Saskatchewan | 26 | 2018-06-01 | 2019-05-15 |
| Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome Allopurinol, Mannitol - Encephalopathy, Hypoxic-Ischemic, Infant, Newborn, Diseases | Phase 3 | Unknown | University Hospital Tuebingen | 760 | 2018-03-25 | 2023-07-11 |
| Effects of Mannitol on Delayed Graft Function After Cadaveric Renal Transplantation Mannitol - Kidney Transplantation, Mannitol | Phase 3 | Completed | Medical University of Vienna | 34 | 2018-01-01 | 2018-11-07 |
| Mannitol Versus Supportive Care in Ciguatera Fish Poisoning Mannitol - Ciguatoxin | Phase 3 | Unknown | University of South Florida | 200 | 2015-10-01 | 2015-10-07 |
| A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy Droxidopa, Placebo - Symptomatic Neurogenic Orthostatic Hypotension, Parkinson's Disease | Phase 3 | Terminated | Chelsea Therapeutics | 61 | 2013-11-01 | 2016-01-08 |
| Efficacy and Safety of BCD-063 and Copaxone-Teva in Patients With Relapsing-Remitting Multiple Sclerosis BCD-063, Copaxone-Teva, Placebo - Relapsing-remitting Multiple Sclerosis | Phase 3 | Completed | Biocad | 158 | 2013-10-01 | 2021-09-16 |
| Gait Analysis Following Knee Viscosupplementation hyaluronic acid with mannitol, hyaluronic acid with sorbitol, Placebos - Gait, Knee Osteoarthritis | Phase 2 / Phase 3 | Completed | Brigitte Jolles, MD | 22 | 2013-05-01 | 2018-08-17 |
| Effect of Addition of Mannitol to Bupivacaine on IANB Success and Post-endodontic Pain bupivacaine plus mannitol, bupivacaine alone - Irreversible Pulpitis | Phase 2 / Phase 3 | Completed | Cairo University | 60 | 2012-12-01 | 2018-11-23 |
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Brain Injuries, Traumatic (5) · Asthma (3) · Intracranial Hypertension (3) · Brain Injuries (2) · Hypoxia-Ischemia, Brain (2) · Parkinson Disease (2) · Asthenia (1) · Brain Concussion (1) · Bronchiectasis (1) · COVID-19 (1) · Coronary Artery Disease (1) · Cystic Fibrosis (1) · Dizziness (1) · Edema (1) · Fatigue (1)
Syntara (3) · Cairo University (2) · Chelsea Therapeutics (2) · AstraZeneca (1) · Biocad (1) · Brigham and Women's Hospital (1) · Brigitte Jolles, MD (1) · Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland (1) · Centre Hospitalier Universitaire de Besancon (1) · Direction Centrale du Service de Santé des Armées (1) · Hamilton Health Sciences Corporation (1) · Institut d'Anesthesiologie des Alpes Maritimes (1) · Makerere University (1) · Mansoura University (1) · Medical University of Vienna (1)
United States (7) · France (4) · Switzerland (4) · United Kingdom (4) · Belgium (3) · Canada (3) · Italy (3) · Netherlands (3) · Spain (3) · Australia (2) · Austria (2) · Egypt (2) · Germany (2) · Poland (2) · Argentina (1)
Andre Lamy, MD (1) · Aria P Hayanto, Sp.An-TI (1) · Axel Franz, Prof. Dr. (1) · Ben WJ Mol, MD, PhD (1) · Blaise Genton, MD-PhD (1) · Brett Charlton (1) · Brett Charlton, MBBS (1) · Brigitte Brigitte (1) · Carin MA Rademaker, PhD (1) · Cristiano Spada, Prof. (1) · David Pearlman, MD (1) · Dr Diana Bilton (1) · Dr Philip Robinson (1) · Dr. Don Cockcroft, MD (1)
PMID 17958887, PMID 19564319, PMID 21478216, PMID 23429964, PMID 24326693, PMID 24352085, PMID 25212745, PMID 25512466, PMID 27538531, PMID 28153869, PMID 28494751, PMID 28822586, PMID 30003579, PMID 30138355, PMID 31024734, PMID 31542451, PMID 31785175, PMID 32358807, PMID 32723374, PMID 32966587, PMID 33735508, PMID 36221362, PMID 36861433, PMID 38267942, PMID 39147988, PMID 42109031
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