14 completed, 5 unknown, 3 terminated, 3 withdrawn. 27 Phase 1, 13 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 27 | Completed 14, Unknown 5, Terminated 3, Withdrawn 3, Enrolling by invitation 1, Not yet recruiting 1 |
| Phase 2 | 13 | Completed 5, Unknown 4, Withdrawn 3, Enrolling by invitation 1 |
Follow Mannitol: new trials by email Literature Review of Mannitol trials Research Report on Mannitol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Novel endOvascular Therapy With beVAcizumab and Cannabinoids for Glioblastoma Bevacizumab - GBM | Phase 1 | Not yet recruiting | Unity Health Toronto | 6 | 2026-12-01 | 2026-11-02 |
| A Dose-Image Optimization Trial Evaluating Mannitol and Voluven as Adjuncts for Indocyanine Green Voluven-assisted Indocyanine green fluorescence guided sentinel lymph node biopsy for breast cancer, Mannitol (20%) - Breast Cancer Early Stage Breast Cancer (Stage 1-3) | Phase 1 / Phase 2 | Enrolling by invitation | National Taiwan University Hospital | 30 | 2025-01-01 | 2025-04-16 |
| Dose-finding PKPD Trial for RE02 in Healthy Subjects RE02, Manitol - Healthy | Phase 1 | Terminated | Reconnect Labs | 4 | 2023-11-20 | 2024-11-27 |
| A Randomized Phase 1 of of MZE001 in Healthy Volunteers MZE001, Placebo - Healthy | Phase 1 | Completed | Maze Therapeutics | 121 | 2022-02-07 | 2023-02-06 |
| A Study of Two Formulations (Both Refrigerated and Room Temperature) Using an Autoinjector Device in Healthy Participants Sodium chloride, Citrate buffer, Mannitol - Healthy Participants | Phase 1 | Completed | Eli Lilly and Company | 44 | 2021-11-24 | 2022-01-13 |
| The Optimal Dose of Mannitol for Intraoperative Brain Relaxation During the Operation of Aneurysmal Subarachnoid Hemorrhage Mannitol - Aneurysmal Subarachnoid Hemorrhage | Phase 1 / Phase 2 | Unknown | Beijing Tiantan Hospital | 99 | 2019-04-20 | 2023-11-30 |
| Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy Mannitol, Menthol - Diabetic Peripheral Neuropathy | Phase 1 / Phase 2 | Completed | University of British Columbia | 72 | 2017-03-15 | 2021-03-02 |
| Mannitol Cream for Post Herpetic Neuralgia Mannitol cream, Placebo - Neuralgia, Postherpetic | Phase 1 / Phase 2 | Completed | University of British Columbia | 20 | 2015-09-30 | 2018-10-23 |
| Phase 1 Study Assessing the Safety and Tolerability of CTX-4430 in Cystic Fibrosis Patients CTX-4430, Placebo - Cystic Fibrosis | Phase 1 | Completed | Celtaxsys, Inc. | 17 | 2013-09-01 | 2015-03-06 |
| Repeatability and Response Study of Absorptive Clearance Scans Absorptive clearance scan, inhaled hypertonic saline (7%), mannitol inhalation powder - Cystic Fibrosis | Phase 1 | Completed | Tim Corcoran | 24 | 2013-06-01 | 2018-11-06 |
| Trial of Mannitol Cream for Pain Relief After a Long Run Mannitol cream, Placebo Cream - Pain | Phase 1 | Completed | University of British Columbia | 170 | 2013-05-01 | 2013-10-11 |
| Phase 1 Study Assessing the Safety and Tolerability of CTX-4430 CTX-4430, Mannitol, Placebo - Pulmonary Inflammation | Phase 1 | Completed | Celtaxsys, Inc. | 96 | 2012-12-01 | 2013-09-10 |
| Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury Induced, sustained hypernatremia using hypertonic saline, Standard of care (hypertonic saline and mannitol; serum sodium) - Traumatic Brain Injury, Subdural Hematoma | Phase 1 / Phase 2 | Withdrawn | Massachusetts General Hospital | 2012-07-01 | 2016-12-12 | |
| Controlled Trial of ABELADRUG200 in Closed, Severe Head Injury AbelaDrug200, mannitol - Severe Head Trauma | Phase 1 / Phase 2 | Unknown | Abela Pharmaceuticals, Inc. | 30 | 2010-10-01 | 2010-12-08 |
| Norwalk Vaccine Study Norwalk VLP vaccine, mannitol and sucrose, Norwalk virus - Acute Gastroenteritis, Norwalk Virus Infection | Phase 1 / Phase 2 | Completed | Takeda | 98 | 2009-08-04 | 2017-08-08 |
| Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Carboplatin, Mannitol, Melphalan - Central Nervous System Embryonal Neoplasm, Embryonal Tumor With Multilayered Rosettes, C19MC-Altered | Phase 1 / Phase 2 | Unknown | OHSU Knight Cancer Institute | 17 | 2009-07-09 | 2021-10-26 |
| High Dose Inhaled Mannitol Study mannitol - Bronchiectasis | Phase 1 / Phase 2 | Completed | Syntara | 10 | 2009-01-01 | 2010-02-26 |
| Pharmacokinetics of Inhaled Mannitol in Cystic Fibrosis Patients Mannitol - Cystic Fibrosis | Phase 1 | Completed | Syntara | 18 | 2008-12-01 | 2010-02-02 |
| Effect of Continuous GHRP-3 Infusion at on GH-IGF-I System, Blood Pressure, Glucose, and Insulin Resistance GHRP-3 low dose, GHRP-3 high dose, Saline - Insulin Resistance, Endothelial Dysfunction | Phase 1 / Phase 2 | Withdrawn | Tulane University Health Sciences Center | 2008-07-01 | 2021-01-08 | |
| Boron Phenylalanine With or Without Mannitol in Treating Patients With Glioblastoma Multiforme boron phenylalanine, mannitol, biologic sample preservation procedure - Brain and Central Nervous System Tumors | Phase 1 | Terminated | Cancer Research UK | 36 | 2007-10-01 | 2013-10-08 |
Showing 20 of 27. Sign in to see all of them.
Cystic Fibrosis (3) · Astrocytoma (2) · Brain Injuries, Traumatic (2) · Central Nervous System Neoplasms (2) · Craniocerebral Trauma (2) · Head Injuries, Closed (2) · Medulloblastoma (2) · Oligodendroglioma (2) · Pain (2) · Brain Contusion (1) · Brain Diseases (1) · Brain Edema (1) · Brain Injuries (1) · Breast Neoplasms (1) · Bronchiectasis (1)
OHSU Knight Cancer Institute (4) · Syntara (4) · University of British Columbia (3) · Celtaxsys, Inc. (2) · Abela Pharmaceuticals, Inc. (1) · Beijing Tiantan Hospital (1) · Cancer Research UK (1) · Eli Lilly and Company (1) · Massachusetts General Hospital (1) · Maze Therapeutics (1) · National Taiwan University Hospital (1) · Reconnect Labs (1) · Takeda (1) · Thomas Jefferson University (1) · Tim Corcoran (1)
United States (9) · Australia (4) · Canada (4) · United Kingdom (3) · China (1) · Switzerland (1) · Taiwan (1)
Edward A Neuwelt (3) · Andrew Humberstone (1) · Brian P Walcott, MD (1) · Brian V Nahed, MD (1) · Clayton D Harro, MD (1) · David Barnes, MBBS FRACP (1) · David I Bernstein, MD (1) · Edward A. Neuwelt, MD (1) · Erich Seifritz, Prof (1) · Garth Cruickshank (1) · Helene Bertrand, MD, CCFP (1) · Helene Bertrand, MD, CM, CCFP (1) · J Stuart Elborn, MD, FRCP (1) · Janakan Krishnarajah, MB, BS FRACP (1) · Mohamed S Al-Ibrahim, MD (1)
PMID 22150036, PMID 22236612, PMID 27009167
R01CA137488 (1), R01HL108929 (1), R01NS044687 (1)