11 completed, 2 not yet recruiting, 1 recruiting, 1 unknown. 15 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 15 | Completed 11, Not yet recruiting 2, Recruiting 1, Unknown 1 |
Follow Hydrocodone: new trials by email Literature Review of Hydrocodone trials Research Report on Hydrocodone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial of MK-6916 in Participants With Pain After Bunion Removal Surgery (MK-6916-007) MK-6916, Hydrocodone/acetaminophen (HB/APAP), MK-6916 Placebo - Pain Management | Phase 2 | Not yet recruiting | Merck Sharp & Dohme LLC | 380 | 2026-11-23 | 2026-10-07 |
| A Clinical Trial of GRT7040 in Adults With Acute Pain Following Bunionectomy GRT7040, Hydrocodone bitartrate/ acetaminophen (HB/APAP), Placebo (matched to HB/APAP) - Acute Pain, Bunionectomy | Phase 2 | Not yet recruiting | Grünenthal GmbH | 400 | 2026-09-01 | 2026-09-15 |
| Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients medrol dosepak, HYDROcodone Oral Tablet - Foot Injuries and Disorders, Ankle Injuries and Disorders | Phase 2 | Recruiting | Emory University | 180 | 2025-01-27 | 2026-03-09 |
| 5x-Multiplier vs 3-Tier Model for Discharge Opioid Prescriptions After Intra-abdominal Cancer Surgery: A Randomized Clinical Trial Hydrocodone, Tramadol, Oxycodone - Intra-abdominal Cancer | Phase 2 | Completed | M.D. Anderson Cancer Center | 165 | 2024-03-27 | 2026-09-09 |
| Naproxen Sodium/Acetaminophen Proof of Concept Dosing Study 440 mg naproxen sodium with 1000 mg acetaminophen, 220 mg naproxen sodium with 650 mg acetaminophen, 10 mg hydrocodone + 650 mg acetaminophen - Pain | Phase 2 | Completed | Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division | 290 | 2019-05-28 | 2022-12-05 |
| Bandage Contact Lenses for Corneal Abrasions Bandage contact lens, Eyedrop, Hydrocodone - Corneal Abrasion, Eye Trauma | Phase 2 | Unknown | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 60 | 2017-07-01 | 2018-02-01 |
| Phase 2 Chronic Low Back Pain Study hydrocodone/acetaminophen extended release, Placebo - Chronic Low Back Pain | Phase 2 | Completed | AbbVie (prior sponsor, Abbott) | 168 | 2011-06-01 | 2014-01-29 |
| Acute Pain Study Following Bunionectomy Hydrocodone/Acetaminophen Extended Release, Placebo - Pain | Phase 2 | Completed | AbbVie (prior sponsor, Abbott) | 100 | 2011-04-01 | 2014-04-08 |
| Hydrocodone/Acetaminophen for Acute Pain Following Bunionectomy Hydrocodone/Acetaminophen Extended Release, Acetaminophen, Morphine Extended Release - Pain | Phase 2 | Completed | AbbVie (prior sponsor, Abbott) | 250 | 2009-12-01 | 2014-04-08 |
| Hydrocodone/Acetaminophen for Acute Pain Following Third Molar Tooth Extraction ABT-712 Extended-release, Hydrocodone/Acetaminophen Immediate-release, Placebo - Pain | Phase 2 | Completed | AbbVie (prior sponsor, Abbott) | 122 | 2009-06-01 | 2014-04-08 |
| A Study Comparing Vicodin® CR and NORCO® to Placebo in Subjects With Acute Pain Following Bunionectomy Hydrocodone/Acetaminophen Extended-Release, Hydrocodone/Acetaminophen Immediate Release (NORCO®), Placebo - Pain | Phase 2 | Completed | Abbott | 90 | 2005-11-01 | 2011-07-25 |
| A Study Comparing the Analgesic Efficacy and Safety of Extended Release Hydrocodone/Acetaminophen (Vicodin® CR)and Placebo in Subjects With Osteoarthritis Extended-Release Hydrocodone/Acetaminophen, Placebo - Pain | Phase 2 | Completed | Abbott | 120 | 2004-08-01 | 2011-01-19 |
| A Study Comparing the Analgesic Activity of Extended Release Hydrocodone/Acetaminophen (Vicodin® CR) and Placebo in Subjects With Pain Following Bunionectomy Surgery Hydrocodone/Acetaminophen Extended Release, Placebo - Pain | Phase 2 | Completed | Abbott | 210 | 2003-10-01 | 2011-01-19 |
| A Safety, Tolerability and Pharmacokinetic Dose Escalation Study of HC-ER in Patients With Osteoarthritis Pain 10 mg of Hydrocodone Bitartrate Extended Release (HC-ER), 20 mg of Hydrocodone Bitartrate Extended Release (HC-ER) - Osteoarthrosis | Phase 2 | Completed | Zogenix, Inc. | 37 | 2002-09-01 | 2022-11-10 |
| A Multicenter Active Comparator Study of HC-ER in Adults Following Bunionectomy Surgery 10 mg HC-ER, 20 mg HC-ER, 30 mg HC-ER - Postoperative Pain | Phase 2 | Completed | Zogenix, Inc. | 241 | 2002-08-01 | 2022-11-10 |
Pain (7) · Pain, Postoperative (2) · Acute Pain (1) · Agnosia (1) · Ankle Injuries (1) · Corneal Injuries (1) · Disease (1) · Eye Injuries (1) · Foot Injuries (1) · Osteoarthritis (1) · Toothache (1)
AbbVie (prior sponsor, Abbott) (4) · Abbott (3) · Zogenix, Inc. (2) · Emory University (1) · Grünenthal GmbH (1) · Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division (1) · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (1) · M.D. Anderson Cancer Center (1) · Merck Sharp & Dohme LLC (1)
United States (9)
Pedro Quintana Diez, MD (4) · Rita Jain, MD (3) · Ching-Wei D Tzeng, MD (1) · Rishin Kadakia, MD (1) · Todd Bertoch, MD (1)