45 completed, 15 unknown, 7 active not recruiting, 5 recruiting. 31 Phase 4, 22 Phase 3, 16 Phase 2, 7 Phase 1, 2 Not applicable.
Follow Forxiga: new trials by email Literature Review of Forxiga trials Research Report on Forxiga
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Dapagliflozin for the Regulation of Immunological Activity in Membranous Nephropathy Forxiga - Glomerulonephritis | Phase 2 | Not yet recruiting | Centre Hospitalier Universitaire de Nice | 20 | 2026-11-01 | 2026-06-22 |
| Dapagliflozin for Anemia in Lower-Risk Myelodysplastic Syndromes Dapagliflozin (10mg Tab) - Myelodysplastic Syndromes (MDS), Anemia | Phase 2 | Not yet recruiting | Seug yun Yoon, MD | 37 | 2026-09-01 | 2026-04-08 |
| Adjuvant Therapy With Letrozole in Induction of Ovulation With Polycystic Ovarian Syndrome Metformin, Dapagliflozin, Dapagliflozin/Metformin - Polycystic Ovary | Phase 3 | Completed | Beni-Suef University | 200 | 2026-03-30 | 2026-06-02 |
| Evaluating Safe Ketone Thresholds To Minimise Ketosis in People With Type 1 Diabetes Using Dapagliflozin FORXIGA - Type 1 Diabetes Mellitus | Phase 2 | Not yet recruiting | St Vincent's Hospital Melbourne | 115 | 2026-02-01 | 2025-11-06 |
| Use of Flozins (Empagliflozin/Dapagliflozin) for Prevention of AKI Flozin - Coronary Artery Disease, Acute Kidney Injury | Recruiting | Collegium Medicum w Bydgoszczy | 4000 | 2025-11-01 | 2025-11-17 | |
| Protecting the Kidney's Proximal Tubules From Platinum-Based Chemotherapy Toxicity Dapagliflozin 10 MG Oral Tablet, Placebo Oral Tablet - Solid Tumors, Cisplatin Nephrotoxicity | Phase 2 | Recruiting | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | 46 | 2025-05-07 | 2026-03-11 |
| Improving Cardiovascular Disease Diagnosis and Treatment in Kazakhstan Using Metabolic Correction With GLP-1 Drugs Tirzepatide (Mounjaro), dapagliflozin, empagliflozin, metformin - Heart Failure, Diabete Type 2 | Not applicable | Active not recruiting | Nazarbayev University | 120 | 2024-12-18 | 2026-01-28 |
| Optimising Metabolic Management for People With Human Immunodeficiency Virus (HIV) on Integrase Based Antiretroviral Therapy (ART) Dapagliflozin 10mg Tab, Pitavastatin 4 Mg Oral Tablet, Rosuvastatin and Ezetimibe - HIV Infections, Weight Gain | Phase 3 | Active not recruiting | Kirby Institute | 300 | 2024-12-16 | 2026-07-22 |
| Acetazolamide Versus Dapagliflozin in Acute Decompensated Heart Failure Patients Acetazolamide, Dapagliflozin 10mg - Acute Decompensated Heart Failure | Phase 3 | Unknown | Helwan University | 60 | 2024-08-24 | 2024-08-05 |
| Effect of the Use of Dapagliflozin in Patients With Refractory Heart Failure Dapagliflozin - Heart Failure | Phase 4 | Active not recruiting | Fundación para la Investigación del Hospital Clínico de Valencia | 31 | 2024-07-30 | 2026-09-09 |
| IV Iron and SGLT2 Inhibitor on Ventricular Function and Myocardial Iron Content in Heart Failure With Iron Deficiency Iron Carboxymaltose, Dapagliflozin 10mg Tab, Placebo of Iron Carboxymaltose - Heart Failure, Systolic, Iron Deficiencies | Phase 3 | Not yet recruiting | Hospital de Clinicas de Porto Alegre | 99 | 2024-05-24 | 2024-06-03 |
| The Effect of Dapagliflozin on Weight Loss in Obese Adults Without Diabetes Dapagliflozin 10mg Tab, Metformin 1000 mg (ttd), Placebo - Obesity, Dapagliflozin Adverse Reaction | Phase 4 | Active not recruiting | Oman Ministry of Health | 150 | 2024-04-22 | 2025-03-26 |
| CardioPROTECTion with Dapagliflozin in Breast Cancer Patients Treated with AnthrAcycline - PROTECTAA TRIAL Dapagliflozin, Placebo - Breast Cancer, Heart Failure | Phase 3 | Recruiting | 4th Military Clinical Hospital with Polyclinic, Poland | 188 | 2024-04-15 | 2024-12-04 |
| SGLT2 Inhibitor TrEatment iN Patients Awaiting cOronary arTery bYpass Surgery to Reduce Post-opErative AF Dapagliflozin 10mg Tab, Placebo Tab - Chronic Coronary Syndrome, Atrial Fibrillation | Phase 3 | Recruiting | Region Örebro County | 800 | 2024-04-04 | 2025-04-08 |
| Association of SGLT2 Inhibitors Therapy With Elastographic and Molecular Markers of Liver Injury in Type 2 Diabetes Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor - Non-Alcoholic Fatty Liver Disease, Diabetes Mellitus, Type 2 | Completed | Josip Juraj Strossmayer University of Osijek | 67 | 2024-03-22 | 2025-12-08 | |
| Effect of Genetic Polymorphisms on the Clinical Response to SGLT2 Inhibitors in Heart Failure Patients SGLT2 inhibitors (Dapagliflozin and Empagliflozin) - Genetic Polymorphisms, Heart Failure | Unknown | October 6 University | 282 | 2023-12-27 | 2024-02-07 | |
| A Study to Investigate the Mechanistic Effects of Dapagliflozin Alone or in Combination With Balcinrenone, Compared to Balcinrenone and Placebo on Body Fluid and Electrolyte Handling and Energy Metabolism in Participants Over 50 Years of Age With Chronic Kidney Disease. Dapagliflozin 10mg Tab, Balcinrenone 50mg Capsule, Balcinrenone 100mg Capsule - Chronic Renal Failure, Mechanistic Effects of SGLT2 Inhibition and/ or MR Antagonism on Body Fluid and Electrolyte Homeostatis | Phase 2 | Completed | Klinikum Nürnberg | 103 | 2023-07-13 | 2026-04-27 |
| Effect of Dapagliflozin on Cardiac Structure, Function and Secondary Mitral Regurgitation in Patients with Left Ventricle Dysfunction Dapagliflozin Farxiga®, Ramipril Tritace®, Carvedilol Carvid®,and Spironolactone Aldactone® - Dilated Cardiomyopathy | Phase 3 | Completed | October 6 University | 150 | 2023-04-27 | 2024-10-16 |
| Clinical Trial to Evaluate the Efficacy and Safety of DA-2811 When Added to Ongoing Metformin Monotherapy in Patients with Type 2 Diabetes Who Have Inadequate Glycemic Control DA-2811, Forxiga - Diabetes Mellitus | Phase 4 | Completed | Dong-A ST Co., Ltd. | 231 | 2023-04-25 | 2025-03-14 |
| SGLT2 Inhibitor in Lupus Nephritis Patients With Chronic Kidney Disease Dapagliflozin 10mg Tab, Standard maintenance therapy - Lupus Nephritis, Chronic Kidney Diseases | Phase 2 | Recruiting | The University of Hong Kong | 150 | 2023-01-04 | 2024-12-16 |
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Diabetes Mellitus, Type 2 (30) · Diabetes Mellitus (12) · Heart Failure (12) · Diabetes Mellitus, Type 1 (6) · Renal Insufficiency, Chronic (4) · Insulin Resistance (3) · Acute Kidney Injury (2) · Anemia (2) · Atherosclerosis (2) · Heart Failure, Systolic (2) · Hyperglycemia (2) · Hypertension (2) · Hypoglycemia (2) · Ketosis (2) · Metabolic Syndrome (2)
AstraZeneca (7) · Dong-A ST Co., Ltd. (5) · University of Guadalajara (5) · Kinderkrankenhaus auf der Bult (3) · October 6 University (2) · Seoul National University Bundang Hospital (2) · The University of Hong Kong (2) · University Medical Center Groningen (2) · University of Dundee (2) · University of Milan (2) · 4th Military Clinical Hospital with Polyclinic, Poland (1) · Amsterdam UMC, location VUmc (1) · Assistance Publique - Hôpitaux de Paris (1) · AstraZeneca Turkey (1) · Beni-Suef University (1)
Mexico (12) · Germany (9) · South Korea (9) · United Kingdom (7) · Italy (6) · Netherlands (6) · Australia (5) · Poland (5) · United States (5) · Egypt (4) · Russia (4) · Brazil (3) · Canada (3) · Czechia (3) · France (3)
Thomas Danne, MD (2) · Adriana Marton, MD (1) · Ahmed Essam Abou Warda (1) · Alexander Ametov, prof., MD (1) · Allan Struthers, MD, FRCP (1) · Alparslan K Tuzcu, Prof.Dr. (1) · Anders Rosengren (1) · Andre GD Vianna, MD (1) · Andrea Di Lenarda, MD (1) · Andrea Mortara, MD (1) · Andrea Ungar, MD (1)
PMID 28605608, PMID 31535829, PMID 11239408, PMID 18599344, PMID 20204386, PMID 20980548, PMID 21398642, PMID 23040716, PMID 25424969, PMID 25937196, PMID 26378978, PMID 26606676, PMID 27422625, PMID 28095900, PMID 28231831, PMID 28376855, PMID 28606345, PMID 28835229, PMID 28950419, PMID 29016744, PMID 29301520, PMID 29371333, PMID 29446769, PMID 29573529, PMID 29947099, PMID 30231923, PMID 30415602, PMID 30559238, PMID 30689697, PMID 30935417, PMID 30990260, PMID 31236801, PMID 31248555, PMID 31412874, PMID 31504439, PMID 31707794, PMID 31816432, PMID 31843945, PMID 32115470, PMID 32144994, PMID 32178931, PMID 32200854, PMID 32245746, PMID 32317958, PMID 32352644, PMID 32403130, PMID 32516291, PMID 32559474, PMID 32578850, PMID 32736592
2015 (4), 2014 (3), 2023 (2), 2016 (1), 2017 (1), 2019 (1), U01DK143330 (1)