15 completed, 3 active not recruiting, 2 terminated, 2 unknown. 11 Not applicable, 7 Phase 2, 7 Phase 3, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Differential Thrombogenesis by EPA and DHA Mediated by HDL EPA, DHA - Lipid Metabolism Disorders, Hypertriglyceridemia | Early Phase 1 | Recruiting | The Miriam Hospital | 80 | 2025-07-10 | 2025-10-01 |
| Cardiometabolic Properties of Omega-3 Functionalized With Hydroxytyrosol EPA + HT, EPA, Sunflower Oil - Hypertriglyceridemia, Normal | Not applicable | Active not recruiting | National Research Council, Spain | 68 | 2025-02-17 | 2025-05-28 |
| Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression Omega 3, Placebo - Treatment Resistant Depression, Inflammation | Phase 2 | Active not recruiting | Massachusetts General Hospital | 14 | 2025-01-30 | 2026-07-01 |
| The Efficacy of Long-Chain Fatty Acids, Eicosapentaenoic Acid (EPA) and Specialized Pro-Resolving Mediators (SPMs), in Treating Long COVID Neuropsychiatric Symptoms Eicosapentaenoic acid (omega-3 fatty acid), Specialized Pro-Resolving Lipid Mediator, Placebo - COVID - 19, Depression - Major Depressive Disorder | Not applicable | Completed | National Science and Technology Council, Taiwan | 54 | 2024-06-01 | 2026-07-21 |
| Efficacy and Safety of Omega 3 Fatty Acid Supplements on Heavy Smokers Omega 3 fatty acid - Lung Cancer | Phase 2 | Unknown | British Columbia Cancer Agency | 42 | 2019-06-01 | 2019-05-07 |
| The Long-term Effect of Marine Omega-3 Fatty Acid Supplementation in Renal Transplantation Omacor, Placebo Oral Capsule - Kidney Transplantation | Phase 3 | Completed | Joe Chan | 174 | 2017-09-01 | 2025-04-03 |
| Role of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Inflammation and Lipids EPA, DHA, sunflower oil - Metabolic Syndrome | Not applicable | Completed | Tufts University | 24 | 2016-03-01 | 2021-04-14 |
| Impact of Smoking Information on Concerns About Radon Radon & Smoking Synergistic, Radon Only, Radon and Smoking Isolated - Lung Neoplasms, Radon Exposure | Not applicable | Completed | Paul Windschitl | 1390 | 2015-08-07 | 2019-04-19 |
| Effects of Eicosapentaenoic Acid on Endothelial Function in Diabetic Subjects Icosapent ethyl - Type 2 Diabetes, Coronary Artery Disease | Phase 3 | Terminated | Brigham and Women's Hospital | 2 | 2015-04-01 | 2022-03-18 |
| Effects of EPA on Prostate Cancer Cells Proliferation and Quality of Life EPA, Placebo - Prostate Cancer | Phase 2 | Active not recruiting | CHU de Quebec-Universite Laval | 130 | 2015-02-12 | 2026-10-23 |
| Clinical Trial of the Effects of DHA in the Treatment of Seizure Disorders Fish Oil, Safflower Oil - Epilepsy (Treatment Refractory) | Phase 2 / Phase 3 | Terminated | The Canadian College of Naturopathic Medicine | 6 | 2013-01-01 | 2023-02-10 |
| The Protective Effect of Omega-3 Fatty Acid on Cognitive Function Among Patients With Mild Dementia EPA, DHA, Placebo - Alzheimer Disease, Dementia Disorder | Not applicable | Completed | Taichung Veterans General Hospital | 163 | 2012-09-23 | 2021-07-26 |
| The Impact of Fish-oil Fatty Acids on Postprandial Vascular Reactivity EPA, DHA, Placebo - Cardiovascular Physiological Phenomena, Endothelial Nitric Oxide Synthase | Not applicable | Completed | University of East Anglia | 28 | 2012-09-01 | 2013-10-16 |
| Phospholipid Hypothesis of Depression: From Molecular Biology, Neuroimaging to Behaviour EPA, DHA, Placebo - Major Depressive Disorder | Not applicable | Completed | National Science and Technology Council, Taiwan | 240 | 2012-08-01 | 2015-11-26 |
| Olive Oil and Nampt on Postprandial Inflammation and Atherosclerosis in the Setting of Metabolic Syndrome Niacin, Saturated meal, Monounsaturated meal - Metabolic Syndrome | Not applicable | Completed | National Research Council, Spain | 40 | 2012-01-01 | 2019-03-13 |
| Study of Vitamin D and Omega-3 Supplementation for Preventing Diabetes Vitamin D3, Omega-3 fatty acid (fish oil), Vitamin D3 placebo - Type 2 Diabetes | Phase 3 | Completed | Brigham and Women's Hospital | 22220 | 2011-11-01 | 2026-04-03 |
| Study on the Possible Effects of Diet Supplementation With Essential Fatty Acids in Chocolate Craving Volunteers Flaxseed oil, Paraffin + # 2 dye - Addictive Behavior, Abstinence Syndrome | Phase 2 / Phase 3 | Completed | Federal University of São Paulo | 30 | 2010-08-01 | 2011-07-12 |
| Time and Dose Evaluation of Stearidonic Acid (SDA) to Eicosapentaenoic Acid (EPA) in Red Blood Cells Safflower Oil, EPA, SDA - Sudden Cardiac Death, Sudden Cardiac Arrest | Not applicable | Completed | Solae, LLC | 137 | 2009-08-01 | 2012-06-18 |
| The Effects of EPA/DHA Supplementation on Cognitive Control in Children With ADHD Eicosapentaenoic acid / Docosahexaenoic acid, Placebo dietary intervention (MUFA) in ADHD group, Placebo dietary intervention (MUFA) in healthy control group - Attention Deficit Hyperactivity Disorder, Healthy | Not applicable | Completed | Unilever R&D | 79 | 2009-01-01 | 2013-12-11 |
| Omega-3 Fatty Acid Deficiency Replacement in Early Schizophrenia Omega-3 Fatty Acids, Olive oil placebo, EPA fish oil concentrate; DHA fish oil concentrate - Schizophrenia, Fatty Acid Deficiency | Phase 2 / Phase 3 | Completed | University of Cincinnati | 2008-01-01 | 2011-08-02 |
Showing 20 of 23. Sign in to see all of them.
Depressive Disorder, Major (3) · Inflammation (3) · Coronary Artery Disease (2) · Diabetes Mellitus, Type 2 (2) · Hypertriglyceridemia (2) · Lung Neoplasms (2) · Metabolic Syndrome (2) · Schizophrenia (2) · Alzheimer Disease (1) · Arthritis, Rheumatoid (1) · Attention Deficit Disorder with Hyperactivity (1) · Behavior, Addictive (1) · Bipolar Disorder (1) · COVID-19 (1) · Cardiovascular Diseases (1)
Brigham and Women's Hospital (2) · National Research Council, Spain (2) · National Science and Technology Council, Taiwan (2) · British Columbia Cancer Agency (1) · CHU de Quebec-Universite Laval (1) · Federal University of São Paulo (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Joe Chan (1) · Massachusetts General Hospital (1) · National Center for Complementary and Integrative Health (NCCIH) (1) · Paul Windschitl (1) · Solae, LLC (1) · Taichung Veterans General Hospital (1) · The Canadian College of Naturopathic Medicine (1) · The Miriam Hospital (1)
United States (9) · Taiwan (3) · Canada (2) · Spain (2) · Brazil (1) · Netherlands (1) · Norway (1) · United Kingdom (1)
Anne Marie Minihane, PhD (1) · Aruna Pradhan, MD, MPH (1) · Branimir Draganov, MD (1) · Ivar Anders Eide, MD, PhD (1) · Jeffrey K Yao, Ph.D., FACB (1) · Joe Chan, MD (1) · Kuan-Pin Su, MD PhD (1) · Mac Burnham, PhD (1) · Marco Hoeksma, PhD (1) · Mark H Rapaport, MD (1) · Morten Reier-Nilsen, MD (1) · My Svensson, MD, PhD (1) · Nagi Kumar, Ph.D. (1)
PMID 25790022, PMID 28648567, PMID 29321047, PMID 34817851, PMID 36532545, PMID 37058600, PMID 37787025, PMID 38519581, PMID 40199888
2016 (1), R01DK088078 (1), R01HL159204 (1)