34 completed, 2 not yet recruiting, 1 enrolling by invitation, 1 recruiting. 14 Phase 1, 11 Not applicable, 6 Early Phase 1, 6 Phase 2, 2 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Endotoxin Exposure to Examine the Role of Inflammation in Alcohol Use Endotoxin, Placebo saline - Alcohol Use Disorder, Inflammatory Response | Phase 2 | Not yet recruiting | University of California, Los Angeles | 64 | 2026-09-01 | 2026-08-28 |
| Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function Short-Chain Fatty Acid Colon-Delivery Capsules, Placebo capsules, Lipopolysaccharide (LPS) - Endotoxemia, Inflammation | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 56 | 2025-10-24 | 2026-07-20 |
| Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia Dexamethasone, Tocilizumab, Anakinra - Sepsis, Neuroinflammatory Response | Phase 4 | Unknown | Radboud University Medical Center | 52 | 2024-10-24 | 2025-04-04 |
| Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma Lipopolysaccharides - Asthma; Eosinophilic, Asthma | Phase 1 | Not yet recruiting | National Jewish Health | 60 | 2024-04-01 | 2024-02-21 |
| Aging and Reward System Response to Inflammation and Anxiety Study Endotoxin, Placebo - Anhedonia, Inflammation | Phase 1 | Completed | University of California, Los Angeles | 40 | 2023-03-29 | 2025-12-11 |
| Effect of Endotoxin on Alcohol Consumption Endotoxin - Alcohol Use Disorder | Phase 2 | Completed | Yale University | 27 | 2022-02-27 | 2025-11-03 |
| An Inflammatory Challenge Using Endotoxin Placebo, Endotoxin - Alcohol Use Disorder, Inflammatory Response | Phase 2 | Completed | University of California, Los Angeles | 20 | 2021-10-19 | 2025-05-01 |
| The Innate Central Nervous System Immune Response to an Experimental Immune Challenge in People With Fibromyalgia Endotoxin, Escherichia Coli, Magnetic Resonance Spectroscopy - Fibromyalgia | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 36 | 2020-03-11 | 2023-04-14 |
| Sleep and Healthy Aging Research on Depression for Younger Women Endotoxin, Placebo - Anhedonia, Depression | Phase 1 | Completed | University of California, Los Angeles | 40 | 2019-10-02 | 2026-01-27 |
| A Study Exploring the Use of Vaccine and Antigen Challenges for Immune Monitoring in Healthy Participants Imvanex, Shingrix, LPS - Healthy | Early Phase 1 | Completed | Janssen Research & Development, LLC | 48 | 2019-04-08 | 2025-02-03 |
| Effects of 20,000 EU of Clinical Center Reference Endotoxin (CCRE) Versus Placebo(ENDOHEART) Clinical Center Reference Endotoxin (CCRE), Normal saline - Healthy | Phase 1 | Completed | University of North Carolina, Chapel Hill | 15 | 2018-10-17 | 2019-09-20 |
| The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor Cells LPS, Placebo - Sepsis, Endotoxemia, Immunosuppression | Not applicable | Completed | Radboud University Medical Center | 12 | 2018-01-05 | 2022-10-06 |
| Sleep and Healthy Aging Research for Depression (SHARE-D) Study Endotoxin, Placebo - Depression in Old Age | Phase 1 | Completed | Michael Irwin, MD | 160 | 2017-08-23 | 2024-09-05 |
| Adrecizumab-LPS Study Endotoxin, Placebo, Adrecizumab - Healthy Volunteers | Phase 1 | Completed | Adrenomed AG | 24 | 2017-01-04 | 2021-02-01 |
| Dose-Related Inflammatory Effects of Intravenous Endotoxin in Humans Endotoxin, Placebo - Healthy | Phase 1 | Completed | Robert J Noveck, M.D. | 23 | 2016-08-01 | 2017-04-11 |
| Effects of Bronchial Segmental Endotoxin Instillation in Humans Saline, Endotoxin - Acute Lung Inflammation | Phase 2 | Enrolling by invitation | National Institutes of Health Clinical Center (CC) | 58 | 2015-06-18 | 2026-10-16 |
| Endotoxin-induced Inflammatory and Behavioral Responses and Predictors of Individual Differences Endotoxin, Placebo - Sickness Behavior | Not applicable | Completed | Karolinska Institutet | 22 | 2015-02-01 | 2015-08-20 |
| PK/PD of EA-230 During Endotoxemia EA-230, Endotoxin, Placebo - Endotoxemia, Systemic Inflammatory Response | Phase 1 | Completed | Radboud University Medical Center | 60 | 2015-02-01 | 2016-06-23 |
| Sleep Health, Inflammation, and Emotion Study Endotoxin, Partial sleep deprivation, Placebo - Depression | Early Phase 1 | Completed | University of California, Los Angeles | 95 | 2014-10-01 | 2021-02-18 |
| The Role of the Gut Microbiota in the Systemic Immune Response During Human Endotoxemia Endotoxin, Vancomycin, Metronidazole, Ciprofloxacin - Endotoxemia | Not applicable | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 16 | 2014-06-01 | 2015-12-30 |
Showing 20 of 40. Sign in to see all of them.
Endotoxemia (10) · Inflammation (8) · Depression (6) · Sepsis (5) · Alcoholism (3) · Illness Behavior (3) · Anhedonia (2) · Asthma (2) · Insulin Resistance (2) · Neuroinflammatory Diseases (2) · Pneumonia (2) · Anemia (1) · Anxiety Disorders (1) · Chronic Pain (1) · Consciousness Disorders (1)
Radboud University Medical Center (9) · University of California, Los Angeles (7) · Karolinska Institutet (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · National Institutes of Health Clinical Center (CC) (2) · University of North Carolina, Chapel Hill (2) · Aarhus University Hospital (1) · Adrenomed AG (1) · Copenhagen University Hospital, Rigshospitalet (1) · Janssen Research & Development, LLC (1) · Michael Irwin, MD (1) · National Cancer Institute (NCI) (1) · National Jewish Health (1) · Pfizer (1) · Robert J Noveck, M.D. (1)
United States (18) · Netherlands (10) · Belgium (2) · Denmark (2) · United Kingdom (2)
Peter Pickkers, MD, PhD (4) · Anthony F Suffredini, M.D. (2) · Lara Ray, PhD (2) · Michael R Irwin, MD (2) · Boushra Dalile, PhD (1) · Chloe C Boyle, PHD (1) · Chloe C Boyle, PhD (1) · David Peden, MD (1) · Delphine L Chen, MD (1) · Hans Hoeven, Prof (1) · Hyong Jin Cho, MD, PhD (1) · Jarred M Younger, PhD (1) · Kristin Verbeke, PhD (1)
PMID 41298372, PMID 16864730, PMID 19376240, PMID 19574441, PMID 20719303, PMID 23060625, PMID 23835341, PMID 25770082, PMID 26360770, PMID 26515417, PMID 27307305, PMID 28515092, PMID 29298938, PMID 30217536, PMID 30418539, PMID 30919998, PMID 31103547, PMID 31632316, PMID 35868533, PMID 35871638, PMID 37256193, PMID 40668551, PMID 41192236
2023 (1), K01AG072049 (1), K24AA025704 (1), R01MH091352 (1), R03AA028361 (1)