10 completed, 1 recruiting. 11 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 10, Recruiting 1 |
Follow Endotoxin: new trials by email Literature Review of Endotoxin trials Research Report on Endotoxin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function Short-Chain Fatty Acid Colon-Delivery Capsules, Placebo capsules, Lipopolysaccharide (LPS) - Endotoxemia, Inflammation | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 56 | 2025-10-24 | 2026-07-20 |
| The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor Cells LPS, Placebo - Sepsis, Endotoxemia, Immunosuppression | Not applicable | Completed | Radboud University Medical Center | 12 | 2018-01-05 | 2022-10-06 |
| Endotoxin-induced Inflammatory and Behavioral Responses and Predictors of Individual Differences Endotoxin, Placebo - Sickness Behavior | Not applicable | Completed | Karolinska Institutet | 22 | 2015-02-01 | 2015-08-20 |
| The Role of the Gut Microbiota in the Systemic Immune Response During Human Endotoxemia Endotoxin, Vancomycin, Metronidazole, Ciprofloxacin - Endotoxemia | Not applicable | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 16 | 2014-06-01 | 2015-12-30 |
| Effect of Lipopolysaccharide on Skeletal Muscle Functions Lipopolysaccharide infusion, saline - Sepsis | Not applicable | Completed | University of Nottingham | 6 | 2011-07-01 | 2018-03-27 |
| Inflammation and Brain Function - Main Study Endotoxin, Placebo - Sickness Behavior | Not applicable | Completed | Karolinska Institutet | 52 | 2010-10-01 | 2018-06-11 |
| Endotoxin & Cytokines. Do Protein Loss and Metabolic Effects Depend on Central Nervous System (CNS) Activation of Stress Hormones or on Local Mechanisms in Muscle and Fat? TNF-alpha, Endotoxin - Inflammation, Glucose Metabolism Disorders | Not applicable | Completed | Aarhus University Hospital | 24 | 2010-06-01 | 2013-01-30 |
| Effects of Iron Loading and Iron Chelation Therapy on Innate Immunity During Human Endotoxemia iron sucrose, Deferasirox, endotoxin - Systemic Inflammatory Process, Anemia | Not applicable | Completed | Radboud University Medical Center | 30 | 2010-02-01 | 2015-11-17 |
| Inflammation and Brain Function - Pilot Study Lipopolysaccharide, Placebo - Sickness Behavior | Not applicable | Completed | Karolinska Institutet | 8 | 2009-10-01 | 2018-06-11 |
| Effect of Intrapulmonary Recombinant Human Activated Protein C (APC) on Coagulation and Inflammation After Lipopolysaccharide (LPS) Drotrecogin alpha, Saline (NaCl 0.9%), Endotoxin - Pneumonia, Lipopolysaccharides | Not applicable | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 52 | 2008-10-01 | 2011-03-16 |
| Anti-inflammatory Effects of GTS-21 After LPS GTS-21, [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], Placebo, Lipopolysaccharide E. Coli 113:H 10:K negative - Endotoxemia, Sepsis | Not applicable | Completed | Radboud University Medical Center | 12 | 2008-08-01 | 2010-11-05 |
Endotoxemia (5) · Inflammation (4) · Illness Behavior (3) · Sepsis (3) · Insulin Resistance (2) · Anemia (1) · Glucose Metabolism Disorders (1) · Inhibition, Psychological (1) · Pneumonia (1) · Van der Woude syndrome (1)
Karolinska Institutet (3) · Radboud University Medical Center (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Aarhus University Hospital (1) · Universitaire Ziekenhuizen KU Leuven (1) · University of Nottingham (1)
Netherlands (4) · Belgium (1) · Denmark (1) · United Kingdom (1)
Boushra Dalile, PhD (1) · Kristin Verbeke, PhD (1) · Lukas Van Oudenhove, MD, PhD (1) · Paul L Greenhaff, PhD (1) · Peter Pickkers, MD, PhD (1) · Tom Van der Poll, MD PhD (1) · W. J. Wiersinga, MD, PhD (1)
PMID 23060625, PMID 23835341, PMID 27307305, PMID 29298938, PMID 30217536, PMID 30418539