27 completed, 3 unknown, 1 enrolling by invitation, 1 recruiting. 33 Phase 1, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 33 | Completed 27, Unknown 3, Enrolling by invitation 1, Recruiting 1, Withdrawn 1 |
| Phase 2 | 6 | Completed 3, Enrolling by invitation 1, Recruiting 1, Withdrawn 1 |
Follow Diclofenac: new trials by email Literature Review of Diclofenac trials Research Report on Diclofenac
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease intra-nasal ketorolac, oral diclofenac - Post Operative Pain, Urolithiasis | Phase 1 / Phase 2 | Recruiting | University of Texas Southwestern Medical Center | 80 | 2025-03-01 | 2026-05-27 |
| Diclofenac Dose Response Study Diclofenac 100mg, Diclofenac 75mg, Diclofenac 50mg - Alcohol Use Disorder (AUD), Alcohol-Related Disorders | Phase 1 | Completed | University of Maryland, Baltimore | 23 | 2024-12-01 | 2026-09-08 |
| Comparison of the Efficacy of Diclofenac Sodium and Subcutaneous 5% Dextrose Injection in Low Back Pain. 5% dextrose prolotherapy, Diclofenac 75mg/ml - Low Back Pain, Mechanical | Phase 1 / Phase 2 | Enrolling by invitation | Aksaray University Training and Research Hospital | 150 | 2024-07-15 | 2025-02-19 |
| Comparative Usability Evaluation of Sustained Acoustic Medicine (SAM) Devices and Topical Gel for OA Knee Pain Sustained Acoustic Device with 2.5% Diclofenac Patch, 1% Diclofenac Topical Gel - Knee Osteoarthritis | Phase 1 / Phase 2 | Completed | ZetrOZ, Inc. | 60 | 2021-08-01 | 2025-05-02 |
| Bioequivalence Study to Compare Diclofenac Potassium Coated Tablet Versus Cataflam® 50 Coated Tablet Diclofenac Potassium coated tablet (50 mg Diclofenac Potassium), Cataflam® 50 coated tablet - Non-steroidal Anti-inflammatory (NSAID), Analgesic | Phase 1 / Phase 2 | Completed | Humanis Saglık Anonim Sirketi | 36 | 2020-08-25 | 2023-12-13 |
| Deflox Tablets Bioequivalence (BE) Trial Deflox®, Cataflam DD® - Healthy | Phase 1 | Completed | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 16 | 2019-09-21 | 2021-02-24 |
| Platelet Rich Plasma Injection Versus Surgical and Medical Treatment of Mild-moderate Carpel Tunnel Syndrome. 30 patients received conventional medical treatment (NSAIDs, diclofenac 150 mg/day for 2 weeks and 1500 g vitamin B 12 per day for 6 weeks) and hand support., 30 patients went to surgical procedure, Injection - Carpal Tunnel | Phase 1 | Unknown | Dalia Salah Saif | 90 | 2018-01-26 | 2020-01-22 |
| Comparative Bioavailability and Local Tolerability of Two Topical Diclofenac Plasters Applied Once and Twice a Day Diclofenac Sodium 140mg Medicated Plaster, Flector® topical plaster containing 180 mg of diclofenac hydroxyethylpyrrolidine equivalent to 140 mg of sodium diclofenac - Bioequivalence Study | Phase 1 | Completed | Fidia Farmaceutici s.p.a. | 52 | 2017-11-28 | 2020-10-14 |
| Comparison of the Bioavailability of Diclofenac in a Combination Product (Diclofenac 2% + Capsaicin 0.075% Topical Gel) With Two Diclofenac Only Products, Diclofenac Mono Gel 2% and Voltarol® 12 Hour Emulgel 2.32% Gel, in Healthy Volunteers Diclofenac Sodium, Diclofenac & Capsaicin, Diclofenac Sodium Topical Gel - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 48 | 2017-04-20 | 2019-03-01 |
| Phase 1 Study of the Effects of Combining Topical FDA-approved Drugs on Age-related Pathways on the Skin of Healthy Volunteers Sirolimus, Metformin, Diclofenac - Aging | Phase 1 | Completed | Anne Chang | 10 | 2017-03-01 | 2019-04-01 |
| To Compare Efficacy of Low Dose Diclofenac (25mg) in Management of Postoperative Pain After Periodontal Flap Surgery low dose diclofenac - Chronic Periodontitis | Phase 1 / Phase 2 | Completed | Tatyasaheb Kore Dental College | 20 | 2016-03-20 | 2018-05-14 |
| Delayed Release Diclofenac Sodium Formulation vs Voltaren® Radiolabelled Diclofenac Tablet A, Radiolabelled Diclofenac tablet B, Radiolabelled Diclofenac tablet C - Pain | Phase 1 | Completed | BDD Pharma Ltd | 36 | 2016-03-01 | 2016-09-28 |
| Pharmacokinetic Non-interaction Study With a Fixed-dose Combination Tablet With Tramadol and Diclofenac Diclofenac sodium 25 mg, Tramadol hydrochloride 25 mg, Diclofenac sodium 25 mg/Tramadol hydrochloride 25 mg - Pharmacokinetics | Phase 1 | Completed | Grünenthal GmbH | 36 | 2015-06-07 | 2018-12-11 |
| Drug Interaction Study of Safinamide and a BCRP Substrate, Diclofenac, Concomitantly Administered to Healthy Volunteers Diclofenac sodium, Diclofenac sodium and safinamide - Healthy | Phase 1 | Completed | Zambon SpA | 24 | 2015-05-01 | 2016-04-15 |
| Assess the Efficacy and Safety in Volunteers of DCF100, TIB200 and SPR300 vs. Placebo and Control(s) in a UV Pain Model Ibuprofen, Diclofenac, Methyl-salicylate / Menthol - Pain | Phase 1 | Completed | Futura Medical Developments Ltd. | 60 | 2015-03-01 | 2021-01-27 |
| Dabigatran in an Interaction Probe Drug Cocktail Caffeine, Diclofenac, Esomeprazole - Healthy Volunteers | Phase 1 | Completed | Turku University Hospital | 16 | 2015-02-01 | 2018-08-14 |
| Pharmacokinetics Study Comparing Topical Diclofenac/Menthol Gels With Voltaren Gel and Oral Diclofenac Sodium Diclofenac sodium, Menthol - Pain | Phase 1 | Completed | GlaxoSmithKline | 18 | 2014-10-01 | 2017-06-29 |
| A Safety Study to Investigate the Skin Irritancy Potential of Diclofenac-Menthol Gel 1% Diclofenac Sodium, 3% Menthol, 0.09% Menthol - Pain | Phase 1 | Completed | GlaxoSmithKline | 36 | 2014-06-01 | 2017-06-29 |
| A Safety Study to Investigate the Skin Sensitization Potential of MFC51123 Diclofenac + Menthol Gel, Diclofenac Only Gel, Menthol Only Gel - Pain | Phase 1 | Completed | GlaxoSmithKline | 227 | 2014-04-01 | 2017-06-28 |
| Pharmacokinetic Drug Interaction Between YH4808 and Diclofenac YH4808, Diclofenac, YH4808+Diclofenac - Healthy | Phase 1 | Completed | Yuhan Corporation | 49 | 2013-07-01 | 2014-01-01 |
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Pain (5) · Inflammation (3) · Alcohol-Related Disorders (1) · Alcoholism (1) · Chemically-Induced Disorders (1) · Chronic Periodontitis (1) · Drinking Behavior (1) · Emergencies (1) · Hepatic Insufficiency (1) · Keratosis, Actinic (1) · Low Back Pain (1) · Macular Edema (1) · Median Neuropathy (1) · Neoplasms (1) · Osteoarthritis, Knee (1)
GlaxoSmithKline (3) · Javelin Pharmaceuticals (3) · Sandoz (3) · Boehringer Ingelheim (2) · Shahid Beheshti University of Medical Sciences (2) · Aksaray University Training and Research Hospital (1) · Anne Chang (1) · BDD Pharma Ltd (1) · Dalia Salah Saif (1) · Fidia Farmaceutici s.p.a. (1) · Futura Medical Developments Ltd. (1) · Grünenthal GmbH (1) · Hospira, now a wholly owned subsidiary of Pfizer (1) · Humanis Saglık Anonim Sirketi (1) · Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany (1)
United States (12) · United Kingdom (3) · Iran (2) · Mexico (2) · Egypt (1) · Finland (1) · India (1) · Italy (1) · Jordan (1) · South Africa (1) · South Korea (1) · Sweden (1) · Switzerland (1) · Turkey (Türkiye) (1)
Paul D. Larsen, M.D. (3) · Anne Chang, MD (1) · Annelize Koch, MBChB (1) · Brett Johnson, MD (1) · Dilip Khambete, MDS (1) · George K Lewis, Ph.D. (1) · Howard NE Stevens (1) · Janghee Hong, Professor (1) · Milko Radicioni, MD (1)
2014 (1)