18 completed, 3 withdrawn, 2 terminated, 2 unknown. 28 Phase 1, 10 Phase 2.
Follow Clonidine: new trials by email Literature Review of Clonidine trials Research Report on Clonidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study Psilocybin, Saline Placebo, Clonidine - Well-Being, Psychological, Psychedelic Experiences | Phase 1 | Not yet recruiting | University of Wisconsin, Madison | 120 | 2027-02-01 | 2026-10-30 |
| Effect of RECK in Posterior Spinal Fusion Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail, Placebo - Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease | Phase 1 / Phase 2 | Withdrawn | University of Maryland, Baltimore | 2025-10-01 | 2025-07-31 | |
| Phase I Study of Ropivacaine, Clonidine, and Betamethasone Combination for Sciatic Nerve Block in the Popliteal Region ropivacaine - Healthy, Nerve Block | Phase 1 | Completed | PHARMAFINA | 12 | 2024-11-13 | 2025-05-18 |
| Efficacy of Intrathecal Clonidine Versus Neostigmine as Adjuvants to Bupivacaine on Postoperative Maternal and Fetal Outcomes After Elective Cesarean Section Clonidine - Postoperative Pain | Phase 1 | Unknown | Assiut University | 111 | 2023-12-01 | 2023-07-13 |
| Consciousness, Psilocybin, and Well-Being Psilocybin, Clonidine, Saline - Healthy, Psychedelic Experiences | Phase 1 | Completed | University of Wisconsin, Madison | 6 | 2023-11-07 | 2025-05-16 |
| Clonidine Versus Tranexamic Acid in Reduction of Blood Loss clonidine group - Blood Loss | Phase 1 | Unknown | Uwakwe Emmanuel Chijioke | 112 | 2022-01-03 | 2022-05-12 |
| Mitigating the Pro-inflammatory Phenotype of Obesity Hydrochlorothiazide 12.5Mg Tab, Clonidine Pill, Placebo - Blood Pressure, Diabetes | Phase 1 | Recruiting | University of Kansas Medical Center | 60 | 2021-07-01 | 2025-06-05 |
| Propofol With Clonidine and Ketamine Throughout Colon Cancer Surgery TCI Propofol Injection - Colon Cancer, Post Operative Pain | Phase 1 | Completed | Egymedicalpedia | 60 | 2021-02-01 | 2022-10-26 |
| Stellate Ganglion Blockade in Corona Virus 2019 (COVID-19) Positive Patients Stellate Ganglion Block - COVID 19, ARDS | Phase 1 | Terminated | University of Nebraska | 1 | 2020-11-15 | 2025-01-20 |
| [11C]Yohimbine PET Study of alpha2-AR [11C]Yohimbine, [11C]Yohimbine (Part B1) and [11C]Yohimbine + clonidine (Part B2) - Healthy Controls | Phase 1 | Completed | Hospices Civils de Lyon | 16 | 2018-05-21 | 2025-09-12 |
| Phase 1 PK, Bioavailability, Safety Study of Clonidine MBT w Catapres in Healthy Volunteers Clonidine MBT 50µg, Clonidine MBT 100µg, Catapres 100μg - Healthy | Phase 1 | Completed | Valerio Therapeutics | 36 | 2015-09-01 | 2016-04-18 |
| Intravenous Clonidine for Sedation in Infants and Children Who Are Mechanically Ventilated - Dosing Finding Study intermittent IV CLON - Mechanical Ventilation Complication | Phase 1 | Completed | Johns Hopkins University | 14 | 2015-09-01 | 2021-03-01 |
| Treatment of Chronic Itch in Atopic Dermatitis (Eczema): Nerve Function Clonidine, Naltrexone - Cutaneous Nerves CNS Itch | Phase 1 | Completed | University of Minnesota | 8 | 2015-07-01 | 2023-01-26 |
| Bioequivalence of Two Transdermal Clonidine Administrations in Healthy Volunteers Catapres-TTS-1, Intervention 1: Catapres-TTS-3, Intervention 2: Catapres-TTS-3 - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 56 | 2014-03-01 | 2015-07-16 |
| Effectiveness of Perineural Clonidine as an Adjuvant With Ropivacaine for Popliteal Nerve Block in Patients Undergoing Foot and Ankle Surgery Clonidine, ropivacaine - Pain | Phase 1 / Phase 2 | Terminated | University of Alabama at Birmingham | 14 | 2014-01-01 | 2016-11-04 |
| Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia Clonidine (Duraclon®) - Encephalopathy, Hypoxic-Ischemic | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 13 | 2013-10-03 | 2018-01-05 |
| Comparison of Postoperative Analgesic Effect of Intrathecal Clonidine and Fentanyl Added to Bupivacaine in Patients Undergoing Cesarean Section distilled water, Clonidine, Fentanyl - Post Operative Pain | Phase 1 / Phase 2 | Completed | Qazvin University Of Medical Sciences | 90 | 2011-08-01 | 2012-05-17 |
| Medications Development for Drug Abuse Disorders Buprenorphine/naloxone, Clonidine, Tramadol ER - Opioid Related Disorders, Opioid Dependence | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 106 | 2010-10-01 | 2017-07-06 |
| Pharmacological Interaction Between Clonidine and Methylenedioxymethamphetamine (MDMA) 3,4-Methylenedioxymethamphetamine, Clonidine, placebo - Mood Disorder, Substance-Related Disorders | Phase 1 | Completed | University Hospital, Basel, Switzerland | 16 | 2010-07-01 | 2013-01-25 |
| Clonidine and Morphine in Caudal Anesthesia Clonidine, Morphine, Bupivacaine plus clonidine and morphine - Postoperative Pain | Phase 1 / Phase 2 | Completed | Federal University of Minas Gerais | 80 | 2008-07-01 | 2010-03-19 |
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Pain, Postoperative (4) · Hypertension (2) · Opioid-Related Disorders (2) · Recurrence (2) · Acute Pain (1) · Agnosia (1) · Amphetamine-Related Disorders (1) · Autonomic Nervous System Diseases (1) · Bites and Stings (1) · COVID-19 (1) · Cocaine-Related Disorders (1) · Colonic Neoplasms (1) · Diabetes Mellitus (1) · Dizziness (1) · Hemorrhage (1)
Johns Hopkins University (3) · National Institute on Drug Abuse (NIDA) (2) · University of Wisconsin, Madison (2) · Assiut University (1) · Boehringer Ingelheim (1) · Egymedicalpedia (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Federal University of Minas Gerais (1) · Hospices Civils de Lyon (1) · Oslo University Hospital (1) · PHARMAFINA (1) · Qazvin University Of Medical Sciences (1) · Satish R. Raj (1) · University Hospital, Basel, Switzerland (1) · University of Alabama at Birmingham (1)
United States (18) · Brazil (1) · Egypt (1) · France (1) · Iran (1) · Nigeria (1) · Norway (1) · Switzerland (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Charles Raison, MD (2) · Kenzie Preston, Ph.D. (2) · Emily M Garland, PhD (1) · Eric C. Strain, M.D. (1) · Estelle B Gauda, MD (1) · Girish Sharma, MD (1) · Italo Biaggioni, MD (1) · Jon B Bergmann, Ass. Prof. (1) · Magda L Fernandes, M (1) · Maria Hordinsky, MD (1) · Matthias E Liechti, MD (1) · Michael Lankhorst, MD (1) · Nirvana Elshalakany, Professor (1)
PMID 10851208, PMID 11927799, PMID 12119802, PMID 12923400, PMID 15738343, PMID 15911704, PMID 16391172, PMID 16533484, PMID 18426998, PMID 19047577, PMID 19687359, PMID 19738158, PMID 22700038, PMID 22801444, PMID 23266540, PMID 24002370, PMID 24227635, PMID 24495468, PMID 24606242, PMID 24649361, PMID 24721800, PMID 25783757, PMID 27778639, PMID 28700791, PMID 28726169, PMID 29634425, PMID 29912955, PMID 32673517, PMID 37238713, PMID 9369256, PMID 9890307
2018 (1), R01DA018125 (1), UL1TR000445 (1)