14 completed, 2 terminated, 1 active not recruiting, 1 recruiting. 13 Not applicable, 5 Phase 1, 1 Early Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Completed 9, Active not recruiting 1, Terminated 1, Unknown 1, Withdrawn 1 |
| Phase 1 | 5 | Completed 4, Terminated 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Recruiting 1 |
Follow Cigarette: new trials by email Literature Review of Cigarette trials Research Report on Cigarette
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacokinetics and Pharmacodynamics of THS With LEVIA Compared to THS With TEREA and to Cigarettes THS with LEVIA (ad libitum), THS with TEREA (ad libitum), THS with LEVIA - Nicotine | Not applicable | Completed | Philip Morris Products S.A. | 24 | 2026-02-01 | 2026-05-05 |
| Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS Cigarette, THS - COPD, Smoking | Not applicable | Active not recruiting | Philip Morris Products S.A. | 290 | 2025-04-02 | 2026-08-31 |
| Informing Oral Nicotine Pouch Regulations to Promote Public Health Biospecimen Collection, Cigarette, Nicotine Oral Pouch - Tobacco-Related Carcinoma | Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 160 | 2025-01-13 | 2026-08-17 |
| Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Established Atherosclerotic Disease Cigarette, THS, Smoking Abstinence - Cardiovascular Diseases, Smoking | Not applicable | Withdrawn | Philip Morris Products S.A. | 2023-03-15 | 2024-11-18 | |
| Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects With Chronic Bronchitis Symptoms. THS use, Cigarette, Smoking Abstinence - COPD, Smoking | Not applicable | Terminated | Philip Morris Products S.A. | 715 | 2022-12-16 | 2024-09-26 |
| Acute Pharmacokinetic and Pharmacodynamic Effects of "Tobacco-Free" Oral Nicotine Pouches in Smokers Nicotine, Cigarette - Nicotine Withdrawal, Nicotine Addiction | Phase 1 | Completed | Johns Hopkins University | 71 | 2022-07-27 | 2026-07-23 |
| Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence P4M3 CA35, P4M3 CM35, CIG - Nicotine, Vaping | Not applicable | Completed | Philip Morris Products S.A. | 74 | 2022-07-15 | 2024-03-13 |
| Comparison of Abdominal Aortic Aneurysm Growth in Adult Smoking Patients Who Either Switch to IQOS, Continue Smoking, or Quit Smoking. IQOS, Cigarette, Smoking Cessation - Smoking, Abdominal Aortic Aneurysm | Not applicable | Completed | Philip Morris Products S.A. | 48 | 2018-10-03 | 2025-08-26 |
| Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette - Cigarette Smoker, Current Every Day Smoker | Early Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 66 | 2018-09-17 | 2026-04-23 |
| Effect of Smoking on Ventilation-Perfusion Ratio cigarette, "dummy cigarette" - Lung Disease | Not applicable | Unknown | Medical University of Vienna | 20 | 2018-09-17 | 2019-03-14 |
| A Study to Assess the Nicotine Pharmacokinetics, Tolerability and Safety With a New Oral Nicotine Replacement Product in Healthy Japanese Smokers Oromucosal Nicotine Spray (ONS), Nicotine Gum, Cigarette - Healthy | Phase 1 | Completed | Janssen Pharmaceutical K.K. | 24 | 2017-12-22 | 2025-02-03 |
| Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome IQOS, Cigarette - Periodontal Diseases, Chronic Periodontitis | Not applicable | Completed | Philip Morris Products S.A. | 179 | 2017-11-07 | 2023-01-30 |
| Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers Cigarette, Nicotine Replacement, Questionnaire Administration - Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma | Not applicable | Completed | M.D. Anderson Cancer Center | 213 | 2017-10-26 | 2025-12-09 |
| Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function Charcoal hookah, E-coal hookah, Cigarette - Smoking, Endothelial Dysfunction | Phase 1 | Terminated | Cedars-Sinai Medical Center | 60 | 2017-08-15 | 2021-04-09 |
| Prefatory Study to Explore Changes in Nasal Mucociliary Clearance and to Standardize Nasal Scraping Procedure Cigarette - Smokers, Never Smokers | Not applicable | Completed | Philip Morris Products S.A. | 14 | 2017-01-21 | 2020-11-20 |
| Nicotine Metabolizers and [11C]-(+)-PHNO cigarette - Nicotine Dependence | Not applicable | Completed | Centre for Addiction and Mental Health | 16 | 2015-06-01 | 2018-09-12 |
| Acute Physiological Effects of Electronic Sigarette vs Cigarette Smoking e-cigarette, cigarette - Individuality | Not applicable | Completed | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 20 | 2014-03-01 | 2014-10-07 |
| Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products Cigarette, NIDA test type with 16.6 mg nicotine, Cigarette, NIDA test type with <0.45 mg nicotine, Electronic cigarette with 18 mg/ml nicotine - Adverse Effect of Other Agents Primarily Affecting the Cardiovascular System, Initial Encounter | Not applicable | Completed | University of California, San Francisco | 81 | 2013-11-03 | 2021-12-27 |
| A Study of Blood Levels of Nicotine Following an Electronic Cigarette CN electronic cigarette 10 mg, CN electronic cigarette 15 mg, Nicorette Inhalator 15 mg - Nicotine Replacement Therapy | Phase 1 | Completed | Simbec Research | 24 | 2012-08-01 | 2016-06-09 |
| Comparison of Hookah and Cigarette Smoking Cigarette, Hookah - Smoking | Phase 1 | Completed | University of California, San Francisco | 13 | 2009-10-01 | 2013-05-24 |
Smoking (9) · Tobacco Use (4) · Vaping (3) · Pulmonary Disease, Chronic Obstructive (2) · Tobacco Use Disorder (2) · Aortic Aneurysm, Abdominal (1) · Atherosclerosis (1) · Cardiovascular Diseases (1) · Chronic Periodontitis (1) · Cigarette Smoking (1) · Coronary Artery Disease (1) · Gingival Diseases (1) · Lung Diseases (1) · Periodontal Diseases (1) · Periodontal Pocket (1)
Philip Morris Products S.A. (8) · Ohio State University Comprehensive Cancer Center (2) · University of California, San Francisco (2) · Cedars-Sinai Medical Center (1) · Centre for Addiction and Mental Health (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · Janssen Pharmaceutical K.K. (1) · Johns Hopkins University (1) · M.D. Anderson Cancer Center (1) · Medical University of Vienna (1) · Simbec Research (1)
United States (10) · Japan (5) · United Kingdom (3) · Bulgaria (2) · Czechia (2) · Germany (2) · Poland (2) · Romania (2) · Slovakia (2) · Austria (1) · Canada (1) · Italy (1)
Christelle Haziza, PhD (5) · Xavier Jaumont, MD (2) · Bernard Le Foll, MD, PHD (1) · Brittney L Keller-Hamilton, PhD, MPH (1) · Frank Lee, MD (1) · Girish Sharma, MBBS (1) · Neal L Benowitz, MD (1) · Patrick Winiger, MD (1) · Paul Cinciripini (1) · Peter Ganz, M.D. (1) · Peter Shields, MD (1) · Ronald Victor, MD (1) · Tory Spindle, PhD (1)
P50CA180890 (1), R01DA042526 (1), R01DA055962 (1), R21DA041596 (1), U01DA045530 (1), U54CA287392 (1)