22 completed, 7 terminated, 2 unknown, 2 withdrawn. 35 Phase 1, 12 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 35 | Completed 22, Terminated 7, Unknown 2, Withdrawn 2, Active not recruiting 1, Not yet recruiting 1 |
| Phase 2 | 12 | Completed 7, Terminated 4, Not yet recruiting 1 |
Follow BOTOX: new trials by email Literature Review of BOTOX trials Research Report on BOTOX
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neoadjuvant Intraprostatic OnabotulinumtoxinA Before Radical Prostatectomy for High-Risk Localized Prostate Cancer OnabotulinumtoxinA (BOTOX®), Normal Saline Placebo - Prostate Cancer | Phase 1 / Phase 2 | Not yet recruiting | The Methodist Hospital Research Institute | 30 | 2026-11-01 | 2026-09-02 |
| A Study to Evaluate Sequential Administration of Injections of AGN-151586 Followed by BOTOX in Adult Participants for Treatment of Glabellar Lines AGN-151586, BOTOX - Glabellar Lines | Phase 1 | Active not recruiting | AbbVie | 143 | 2026-08-10 | 2026-11-02 |
| Management of Bruxism in Patients With Implant Overdenture Botulinium toxin type A injection, Maxillary Occlusal Stabilization Splint - Bruxism | Phase 1 | Completed | Delta University for Science and Technology | 48 | 2024-03-24 | 2026-01-23 |
| Study of Intramuscular Injections of ABBV-950 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Upper Limb Spasticity ABBV-950, BOTOX, Placebo for ABBV-950 - Upper Limb Spasticity | Phase 1 | Terminated | AbbVie | 1 | 2024-01-12 | 2024-07-01 |
| A Study to Evaluate Sequential Administration of AGN-151586 and OnabotulinumtoxinA (BOTOX) Injections in Adult Participants for Treatment of Glabellar Lines AGN-151586, BOTOX, Placebo - Glabellar Lines | Phase 1 | Completed | AbbVie | 90 | 2022-08-30 | 2026-06-26 |
| Botulinum Toxin Type A for Cold Intolerance Secondary to Digital Amputations and Replantations: A Pilot Study Botulinum toxin type A - Cold Intolerance | Phase 1 | Unknown | Massachusetts General Hospital | 28 | 2021-06-02 | 2022-08-24 |
| Investigating Effects of BOTOX on Weight Loss and Glucose Tolerance in Obese, Type 2 Diabetic Subjects Botox 200 UNT Injection - Obese, Diabetes Mellitus, Type 2 | Phase 1 / Phase 2 | Terminated | Vanderbilt University Medical Center | 4 | 2021-04-29 | 2023-02-28 |
| Intradermal (ID) BOTOX in the Treatment of Facial Fine Lines Botox, Placebo - Facial Fine Lines | Phase 1 | Completed | Allergan | 172 | 2020-11-16 | 2021-11-16 |
| Botox for the Treatment of Chronic Exertional Compartment Syndrome OnabotulinumtoxinA Injection - Compartment Syndrome of Leg | Phase 1 / Phase 2 | Terminated | University of Wisconsin, Madison | 7 | 2019-10-08 | 2023-02-14 |
| Trial of OnabotulinumtoxinA for Depression in Parkinson Disease OnabotulinumtoxinA, Control - Parkinson Disease, Depression | Phase 1 | Terminated | Johns Hopkins University | 3 | 2018-11-01 | 2019-08-06 |
| Pharmacodynamic and Safety of MBA-P01 in Healthy Male Volunteers MBA-P01, BOTOX - Healthy | Phase 1 | Completed | Medy-Tox | 28 | 2018-04-16 | 2019-03-26 |
| Anhidrotic Area and Safety of MEDITOXIN in Healthy Male Valunteers Meditoxin, Botox - Anhidrotic Area, Hyperhidrosis | Phase 1 | Completed | Medy-Tox | 13 | 2018-03-20 | 2019-03-26 |
| Treatment of MEDITOXIN® in Female Patients With Idiopathic Overactive Bladder Meditoxin, Botox - Overactive Bladder | Phase 1 | Completed | Medy-Tox | 30 | 2017-12-13 | 2019-03-27 |
| Pharmacodynamic and Safety of MEDITOXIN® in Healthy Male Volunteers Meditoxin, Botox - Healthy | Phase 1 | Completed | Medy-Tox | 25 | 2017-10-12 | 2019-03-27 |
| Botulinum Toxin Type A Block of the Otic Ganglion in Chronic Cluster Headache: Safety Issues Botulinum Toxin Type A 25 IU, Botulinum Toxin Type A 12.5 IU - Cluster Headache | Phase 1 / Phase 2 | Completed | Norwegian University of Science and Technology | 10 | 2017-04-18 | 2021-06-23 |
| Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Botulinum Toxin Type A - Trigeminal Neuralgia, Headache Disorders | Phase 1 / Phase 2 | Completed | Norwegian University of Science and Technology | 10 | 2016-05-01 | 2019-07-29 |
| New Approaches in Evaluating Patients' Response to Botulinum Toxins in the Treatment of Chronic Neck Pain and Back Pain Botulinum Toxins - Cervicalgia, Low Back Pain | Phase 1 | Unknown | VA Connecticut Healthcare System | 60 | 2016-03-01 | 2017-12-07 |
| Itch Relieving Effect of Botox: a Study in Healthy Subjects Botox, Saline - Pruritus | Phase 1 / Phase 2 | Completed | Temple University | 35 | 2016-02-01 | 2017-04-27 |
| Temporary Autonomic Blockade to Prevent Atrial Fibrillation After Cardiac Surgery Botulinum Toxin Type A, Placebo - Atrial Fibrillation | Phase 1 / Phase 2 | Completed | Joseph Mathew, M.D. | 130 | 2015-09-01 | 2019-02-22 |
| Botox Injection in Treatment of Chronic Migraine Botulinum Toxin Type A - Migraine Disorders | Phase 1 / Phase 2 | Completed | Norwegian University of Science and Technology | 10 | 2015-02-01 | 2016-05-23 |
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Obesity (3) · Urinary Bladder, Overactive (3) · Bruxism (2) · Cluster Headache (2) · Headache Disorders (2) · Atrial Fibrillation (1) · Congenital torticollis (1) · Depression (1) · Diabetes Mellitus, Type 2 (1) · Dry Eye Syndromes (1) · Dyspareunia (1) · Feeding Behavior (1) · Ganglion Cysts (1) · Hyperhidrosis (1) · Low Back Pain (1)
Mayo Clinic (5) · Medy-Tox (5) · Norwegian University of Science and Technology (4) · AbbVie (3) · Allergan (1) · Delta University for Science and Technology (1) · Instituto de Oftalmología Fundación Conde de Valenciana (1) · Johns Hopkins University (1) · Joseph Mathew, M.D. (1) · Massachusetts General Hospital (1) · Mount Sinai Hospital, Canada (1) · Plastic Surgery Professional Association (1) · Queen's University (1) · Temple University (1) · The Methodist Hospital Research Institute (1)
United States (19) · South Korea (5) · Norway (4) · Canada (3) · Egypt (1) · Israel (1)
Erling A Tronvik, PhD, MD (2) · Alan A Harvey, DMD (1) · Alexander Pantelyat, MD (1) · Ami Sidi, Prof MD (1) · Andrea J. Boon, M.D. (1) · Barham K AbuDayyeh, MD (1) · Brian Miles, MD (1) · Daniel F Bratbak, MD (1) · Gil Yosipovitch, MD (1) · Hajime A Tokuno, MD (1) · J. Curtis Nickel, MD FRCSC (1) · Jonathan M Winograd, MD (1) · Juan Carlos Serna-Ojeda, MD (1)
PMID 19648387, PMID 23063681, PMID 26232105, PMID 26748219, PMID 27154997, PMID 28363809, PMID 31342515, PMID 32583902
2014 (1), 2015 (1), 2016 (1)