149 completed, 36 terminated, 35 unknown, 15 recruiting. 74 Phase 2, 63 Phase 3, 60 Phase 4, 35 Phase 1, 34 Not applicable.
Follow BOTOX: new trials by email Literature Review of BOTOX trials Research Report on BOTOX
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Randomized Trial of Botulinum Toxin A vs Strabismus Surgery for Esotropia >10 to ≤30PD Botulinum toxin A, bilateral medial rectus recession - Esotropia | Phase 3 | Not yet recruiting | Jaeb Center for Health Research | 244 | 2027-01-01 | 2026-04-06 |
| Evaluation of the Efficacy and Safety of Fractional CO₂ Laser With and Without Intradermal Botulinum Toxin A in the Treatment of Inflammatory Facial Acne Vulgaris. Fractional co2 laser, Botulinium Toxin-A - Acne, Acne Papulopustulosa | Phase 3 | Not yet recruiting | Cairo University | 24 | 2026-11-06 | 2026-11-05 |
| Neoadjuvant Intraprostatic OnabotulinumtoxinA Before Radical Prostatectomy for High-Risk Localized Prostate Cancer OnabotulinumtoxinA (BOTOX®), Normal Saline Placebo - Prostate Cancer | Phase 1 / Phase 2 | Not yet recruiting | The Methodist Hospital Research Institute | 30 | 2026-11-01 | 2026-09-02 |
| MRI Study of OnabotulinumtoxinA (OnabotA) Effect on Jaw Muscle Pain Onabotulinumtoxin A, Placebo - Masticatory Myofascial Pain Syndrome | Phase 2 | Not yet recruiting | Weill Medical College of Cornell University | 120 | 2026-10-01 | 2026-10-16 |
| A Study to Evaluate Sequential Administration of Injections of AGN-151586 Followed by BOTOX in Adult Participants for Treatment of Glabellar Lines AGN-151586, BOTOX - Glabellar Lines | Phase 1 | Active not recruiting | AbbVie | 143 | 2026-08-10 | 2026-11-02 |
| Comparative Efficacy and Safety if Intravesical Botulinum Toxin A Versus Platelet-Rich Plasma in the Management of Refractory Overactive Bladder : A 2 Year Study Intravesical Botulinum Toxin A (100U), Intravesical Platelet-Rich Plasma - Overactive Bladder | Not applicable | Active not recruiting | Mahmoud Mohamed Farag Ali | 60 | 2026-06-01 | 2026-07-09 |
| Cleft Lip Scarring After Botox Botulinum Toxin Type A (BOTOX) Injection, Normal Saline - Cleft Lip, Cleft Lip Scar | Phase 2 | Recruiting | Children's National Research Institute | 40 | 2026-02-19 | 2026-10-19 |
| Vertical Facial Morphology and Occlusal Force Changes After Masseter Botulinum Toxin Injection in Bruxism Botulinum Toxin Type A (BOTOX) Injection - Bruxism, Occlusal Changes | Not applicable | Completed | Biruni University | 34 | 2026-02-09 | 2026-06-29 |
| Botulinum Toxin A Before Hemorrhoidectomy to Prevent Postoperative Pain Botulinum toxin type A, Saline (0.9% NaCl) - Hemorrhoids, Postoperative Pain | Phase 2 | Recruiting | Lomonosov Moscow State University Medical Research and Educational Center | 292 | 2026-02-01 | 2026-03-10 |
| Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities Cryoneurolysis, Botulinum toxin - Centreal Neurological Condition, Acquired Brain Injury (Including Stroke) | Phase 4 | Recruiting | Oxford University Hospitals NHS Trust | 50 | 2025-12-02 | 2026-11-05 |
| Assessing the Genitourinary Microbiome of Women With Overactive Bladder Undergoing Onabotulinum Toxin Type A Intradetrusor Injections onabotulinum toxin type a - Overactive Bladder (OAB), Urge Incontinence | Recruiting | Alexis Dieter | 40 | 2025-09-03 | 2025-09-12 | |
| Treatment of Lower Leg Anterolateral Chronic Exertional Compartment Syndrome With Intra-muscular Botulinum Injections. Botulinum toxin A, Normal saline - Chronic Exertional Compartment Syndrome | Not applicable | Recruiting | University of Calgary | 50 | 2025-07-17 | 2026-05-13 |
| Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome Capsaicin 8% Patch, Serratus Plane Block, Botulinum Toxin A - Post-Mastectomy Neuropathic Pain Syndrome | Phase 2 | Withdrawn | Centre Oscar Lambret | 2025-06-10 | 2026-10-06 | |
| Female Sexual Dysfunction Assessment and Managment of Vaginismus Botox, Radiofrequency - Female Sexual Dysfunction | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 40 | 2025-01-01 | 2025-01-01 |
| Efficacy of Nerve Block Versus Botox in Chronic Migraine Management Nerve Block Injections, Botulinum Toxin A - Chronic Migraine, Chronic Migraine, Headache | Not applicable | Recruiting | Zagazig University | 64 | 2024-11-10 | 2024-11-12 |
| Evaluation of Efficacy of Botulinum Toxin A Plus Oral Tadalafil 5 mg in Diabetic Men With Erectile Dysfunction Botulinum toxin A, Tadalafil 5mg - Erectile Dysfunction With Diabetes Mellitus | Phase 2 / Phase 3 | Recruiting | Aswan University Hospital | 32 | 2024-08-01 | 2024-12-03 |
| OnabotulinumtoxinA for Trigeminal Neuralgia OnabotulinumtoxinA 100 UNT [Botox], Sodium Chloride 0.9% for Injection, Preservative Free - Trigeminal Neuralgia | Phase 4 | Recruiting | Stanford University | 20 | 2024-06-01 | 2026-01-22 |
| A Study to Assess BOTOX Injections for the Change of Masseter Muscle Prominence in Adult Participants BOTOX, Placebo - Masseter Muscle Prominence | Phase 3 | Completed | AbbVie | 207 | 2024-04-30 | 2026-08-12 |
| A Study to Assess BOTOX Injections in Adult Participants for the Change of Masseter Muscle Prominence BOTOX, Placebo - Masseter Muscle Prominence | Phase 3 | Completed | AbbVie | 202 | 2024-04-22 | 2026-08-25 |
| Migraine Medication Effects on Urinary Symptoms Ubrogepant, Rimegepant, Atogepant - Overactive Bladder, Bladder Pain Syndrome | Enrolling by invitation | The Cleveland Clinic | 200 | 2024-04-05 | 2026-10-19 |
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Urinary Bladder, Overactive (20) · Muscle Spasticity (16) · Migraine Disorders (13) · Pain (12) · Stroke (11) · Cystitis, Interstitial (9) · Urinary Incontinence (9) · Cerebral Palsy (7) · Urinary Incontinence, Urge (6) · Bruxism (5) · Neuralgia (5) · Spinal Cord Injuries (5) · Hyperhidrosis (4) · Prostatic Hyperplasia (4) · Torticollis (4)
AbbVie (15) · Medy-Tox (10) · Norwegian University of Science and Technology (8) · Mayo Clinic (7) · Cairo University (6) · Weill Medical College of Cornell University (5) · Northwestern University (4) · St. Olavs Hospital (4) · University of British Columbia (4) · Wake Forest University Health Sciences (4) · Allergan (3) · Buddhist Tzu Chi General Hospital (3) · GlaxoSmithKline (3) · Massachusetts General Hospital (3) · The University of Texas Health Science Center, Houston (3)
United States (128) · Canada (21) · Norway (16) · Egypt (14) · South Korea (11) · France (9) · Taiwan (8) · Turkey (Türkiye) (7) · United Kingdom (7) · Germany (6) · Spain (5) · Israel (4) · Switzerland (4) · Belgium (3) · Brazil (3)
Erling A Tronvik, PhD, MD (2) · Hann-Chorng Kuo, M.D. (2) · Keith Jarvi, MD (2) · Michael Suer, MD (2) · Murad Alam, MD (2) · Nina Bohm-Starke, MD (2) · AbdelMaguid I Ramzy, MD (1) · Ahmed Bessar, MD, PhD (1) · Ahmed M Abdelhamid, PhD (1) · Alan A Harvey, DMD (1) · Alastair Carruthers, MD (1)
PMID 10395629, PMID 11743295, PMID 12893330, PMID 12907905, PMID 1451966, PMID 15126771, PMID 15291863, PMID 15538257, PMID 16400513, PMID 18461049, PMID 18478352, PMID 18499184, PMID 18844269, PMID 19054163, PMID 19194764, PMID 19568011, PMID 19648387, PMID 19734516, PMID 19737151, PMID 19811515, PMID 20627413, PMID 20810509, PMID 21556039, PMID 21699810, PMID 21791356, PMID 21868066, PMID 22071153, PMID 22370242, PMID 22616652, PMID 22747635, PMID 23063681, PMID 23064478, PMID 23098762, PMID 23113942, PMID 23370086, PMID 24269277, PMID 24345483, PMID 24486637, PMID 24852565, PMID 25199575, PMID 25311357, PMID 25515292, PMID 25596103, PMID 25683315, PMID 26232105, PMID 26233808, PMID 26392035, PMID 26394198, PMID 26748219, PMID 26808752
2014 (3), 2017 (3), 2016 (2), 2018 (2), 2015 (1), 2019 (1), K08AR080844 (1), R15HD071397 (1), R21HD048972 (1), R33AT012270 (1), U01HD069031 (1), UG1EY011751 (1)