11 terminated. 11 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Terminated 11 |
| Phase 2 | 3 | Terminated 3 |
Follow Ascorbic Acid: new trials by email Literature Review of Ascorbic Acid trials Research Report on Ascorbic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HAT for the Treatment of Sepsis Associated With NASTI HAT, Placebo - Necrotizing Soft Tissue Infection, Sepsis | Phase 1 / Phase 2 | Terminated | Ascension Health | 10 | 2021-09-10 | 2024-07-24 |
| Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock Stress-dose Hydrocortisone plus Vitamin C, isotonic sodium chloride solution placebo plus isotonic sodium chloride solution placebo - Septic Shock | Phase 1 / Phase 2 | Terminated | University of Athens | 26 | 2018-09-06 | 2024-12-19 |
| Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function Charcoal hookah, E-coal hookah, Cigarette - Smoking, Endothelial Dysfunction | Phase 1 | Terminated | Cedars-Sinai Medical Center | 60 | 2017-08-15 | 2021-04-09 |
| High Dose Vitamin C in Cardiac Surgery Patients Ascorbic Acid, Placebo - Disorder of Vitamin C, Atrial Fibrillation | Phase 1 | Terminated | Virginia Commonwealth University | 6 | 2017-01-01 | 2019-06-24 |
| Bevacizumab and Ascorbic Acid in Patients Treating With Recurrent High Grade Glioma Ascorbic Acid, Bevacizumab, Laboratory Biomarker Analysis - Glioblastoma, Glioma | Phase 1 | Terminated | University of Nebraska | 9 | 2016-03-01 | 2023-10-24 |
| Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma ascorbic acid, temozolomide, quality-of-life assessment - Anaplastic Astrocytoma, Anaplastic Oligodendroglioma | Phase 1 | Terminated | University of Nebraska | 4 | 2014-06-16 | 2023-11-24 |
| Safety & Efficacy Study of Gemcitabine...With High Dose IV Vit. C (HDIVC) Gemcitabine, Intravenous and oral Ascorbic Acid (Vitamin C) - Metastatic Adenocarcinoma of the Pancreas | Phase 1 | Terminated | Eastern Regional Medical Center | 3 | 2012-06-01 | 2018-07-26 |
| Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CA Ascorbic Acid, Irinotecan - Stage IV Colorectal Cancer | Phase 1 / Phase 2 | Terminated | Thomas Jefferson University | 4 | 2011-12-01 | 2025-05-06 |
| Arsenic Trioxide With or Without Ascorbic Acid in Treating Patients With Myelofibrosis Arsenic Trioxide, Ascorbic Acid, Laboratory Biomarker Analysis - Essential Thrombocythemia, Polycythemia Vera | Phase 1 | Terminated | Roswell Park Cancer Institute | 5 | 2010-04-01 | 2022-07-22 |
| Trisenox, Ascorbic Acid and Bortezomib in Patients With Relapsed/Refractory Multiple Myeloma Arsenic Trioxide, Ascorbic Acid and Bortezomib - Multiple Myeloma | Phase 1 | Terminated | Duke University | 25 | 2008-07-01 | 2014-01-08 |
| Clinical Utility of Endothelial Dysfunction in PAD atorvastatin, ascorbic acid, Placebo - Peripheral Arterial Disease | Phase 1 | Terminated | Boston University | 108 | 2004-05-01 | 2018-07-27 |
Glioblastoma (2) · Astrocytoma (1) · Atrial Fibrillation (1) · Colonic Diseases (1) · Colorectal Neoplasms (1) · Digestive System Diseases (1) · Digestive System Neoplasms (1) · Gastrointestinal Diseases (1) · Gastrointestinal Neoplasms (1) · Glioma (1) · Gliosarcoma (1) · Heart Valve Diseases (1) · Intestinal Diseases (1) · Intestinal Neoplasms (1) · Multiple Myeloma (1)
University of Nebraska (2) · Ascension Health (1) · Boston University (1) · Cedars-Sinai Medical Center (1) · Duke University (1) · Eastern Regional Medical Center (1) · Roswell Park Cancer Institute (1) · Thomas Jefferson University (1) · University of Athens (1) · Virginia Commonwealth University (1)
United States (10) · Greece (1)
Anastasia Kotanidou, MD, PhD (1) · Cristina Gasparetto, MD (1) · Daniel A Monti, MD (1) · Donald F Brophy, PharmD (1) · Eiko Klimant, MD, FACP (1) · Eunice Wang, MD (1) · Heather Wright, ND, FABNO (1) · Naomi Hamburg, MD (1) · Nicole A Shonka, MD (1) · Nicole Shonka, MD (1) · Ronald Victor, MD (1) · Spyros D Mentzelopoulos, MD, PhD (1) · Spyros G Zakynthinos, MD. PhD (1) · Stylianos Orfanos, MD, PhD (1) · Thomas Resch, M.D. (1)
P30CA036727 (2), R21DA041596 (1)