75 completed, 26 terminated, 22 unknown, 13 withdrawn. 155 Phase 2, 26 Phase 1, 23 Phase 3.
Follow Ascorbic Acid: new trials by email Literature Review of Ascorbic Acid trials Research Report on Ascorbic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy Ascorbic acid, Placebo - Chronic Rhinosinusitis, Intraoperative Bleeding | Phase 2 | Not yet recruiting | Assiut University | 78 | 2026-11-01 | 2026-10-08 |
| NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC Short-Course Radiotherapy, PD-1 monoclonal antibody, mFOLFOX6 regimen - Rectal Adenocarcinoma, High-Risk Cancer | Phase 2 | Not yet recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 100 | 2026-09-01 | 2026-08-14 |
| A Study of CA201A Eye Drops to Prevent Corneal Endothelial Cell Loss in Patients Undergoing Cataract Surgery Ophthalmic solution (matching formulation without ascorbic acid), Ascorbic acid ophthalmic solution 5% - Corneal Endothelial Cell Loss, Corneal Endothelial Damage Following the Hard Nuclear Cataract Surgery | Phase 2 | Recruiting | Caravel Oculus Pty Ltd | 200 | 2026-07-28 | 2026-08-06 |
| Renoprotective Role of Vitamin C and Coenzyme Q10 in Nephrotoxicity Vitamin C, Coenzyme Q 10 - Nephrotoxicity | Phase 2 / Phase 3 | Not yet recruiting | Ain Shams University | 75 | 2026-04-20 | 2026-03-17 |
| Ascorbate in Myelodysplastic Syndrome High-dose ascorbate, Azacitidine - Myelodysplastic Syndromes | Phase 2 | Suspended | Prajwal Dhakal | 38 | 2026-03-11 | 2026-10-09 |
| Rutin and Vitamin C in Patients With Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) Rutin + Vitamin C, Vitamin C 500mg, Lifestyle Intervention - NAFLD | Phase 2 | Not yet recruiting | Ain Shams University | 120 | 2026-01-01 | 2025-12-30 |
| A Clinical Trial Evaluating the Effect of Pharmacological Ascorbate on Radiation Therapy for Pancreatic Cancer Patients Ascorbate, Gemcitabine, radiation therapy - Pancreatic Neoplasm | Phase 2 | Withdrawn | Joseph J. Cullen, MD, FACS | 2025-12-31 | 2025-03-10 | |
| Effect of Metabolic Modulation on a Post-acute COVID-19 Vaccination Syndrome (PACVS) Cohort Combined metabolic modulator, Rice Protein Powder with Vitamin C - Vaccine Adverse Reaction, Post Acute Covid-19 Vaccination Syndrome | Phase 2 | Not yet recruiting | Independent Medical Alliance | 100 | 2025-09-01 | 2025-05-13 |
| Gingival Hyperpigmentation Treatment Vitamin c and glutathione, Surgical depigmentation - Gingival Pigmentation, Depigmentation | Phase 2 | Recruiting | Cairo University | 30 | 2025-08-01 | 2026-05-19 |
| Efficacy of Microneedling With Vitamin C in Performing Gingival Depigmentation Vitamin C, Microneedling, Diode laser - Gingival Pigmentation | Phase 1 / Phase 2 | Not yet recruiting | Fayoum University | 30 | 2025-07-01 | 2025-07-17 |
| Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation Metformin, Rapamycin, Naltrexone - Longevity, GLP-1 | Phase 2 / Phase 3 | Recruiting | AgelessRx | 150 | 2024-12-17 | 2025-07-30 |
| Reducing Frailty for Older Cancer Survivors Using Supplements II Epigallocatechin-3-Gallate (EGCG), Microcrystalline cellulose (MCC), Ascorbic Acid (Vitamin C) - Frailty, Inflammation | Phase 2 | Suspended | University of Rochester | 118 | 2024-10-25 | 2026-06-26 |
| Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer Ascorbic acid, Normal Saline - Lung Cancer | Phase 2 | Terminated | The Canadian College of Naturopathic Medicine | 3 | 2024-10-01 | 2026-10-14 |
| Effect of Vitamin C on Postoperative Pulmonary Complications After Intracranial Tumor Surgery Ascorbic acid, Saline - Ascorbic Acid, Neurosurgical Procedures | Phase 2 | Unknown | Qianfoshan Hospital | 86 | 2024-06-01 | 2024-05-20 |
| Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty Vitamin C, Placebo - Chronic Pain, Knee Pain Chronic | Phase 2 | Recruiting | University Health Network, Toronto | 400 | 2024-04-16 | 2026-06-23 |
| Efficacy of Early Intravenous High-dose Vitamin C in Post-cardiac Arrest Shock. Vitamin C (Laroscorbine) + Vitamin B1 (Bevitine), standard treatment - Cardiac Arrest | Phase 2 | Terminated | Centre Hospitalier de Bethune | 65 | 2023-12-27 | 2026-10-27 |
| Effect of Vitamin C Supplementation in Patients With Primary Hypothyroidism Vitamin C, Oral Rehydration Salt Formulations - Hypothyroidism, Primary Hypothyroidism | Phase 2 | Unknown | Dr Adnan Agha | 40 | 2023-11-01 | 2024-01-11 |
| Vitamin C Effectiveness in Preventing Urinary Tract Infections After Gynecological Surgeries Ascorbic Acid 1000 MG, Placebo - Catheter-Associated Urinary Tract Infection | Phase 2 | Completed | American University of Beirut Medical Center | 200 | 2023-09-19 | 2026-10-28 |
| Vitamin C to Quality of Life in Patients With Terminal Stage Pancreatic Cancer Ascorbate - Metastatic Pancreatic Cancer, Terminal Cancer | Phase 2 | Unknown | Fudan University | 20 | 2023-08-25 | 2024-06-06 |
| Phase II Study of PARP Inhibitor Olaparib and IV Ascorbate in Castration Resistant Prostate Cancer Olaparib, Vitamin C - Prostate Cancer, Castration-resistant Prostate Cancer | Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 4 | 2023-06-30 | 2025-01-29 |
Showing 20 of 155. Sign in to see all of them.
Sepsis (15) · Pancreatic Neoplasms (12) · COVID-19 (11) · Shock, Septic (11) · Multiple Myeloma (10) · Myelodysplastic Syndromes (8) · Neoplasms (8) · Neoplasms, Plasma Cell (6) · Acute Lung Injury (5) · Carcinoma, Non-Small-Cell Lung (4) · Colorectal Neoplasms (4) · Leukemia, Myeloid, Acute (4) · Coronavirus Infections (3) · Fatigue (3) · Heart Arrest (3)
Virginia Commonwealth University (6) · Ain Shams University (5) · Thomas Jefferson University (4) · Jewish General Hospital (3) · Joseph J. Cullen, MD, FACS (3) · Oncotherapeutics (3) · Case Comprehensive Cancer Center (2) · Clifford Hospital, Guangzhou, China (2) · Jeanne Drisko, MD, CNS, FACN (2) · M.D. Anderson Cancer Center (2) · ProgenaBiome (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Spherium Biomed (2) · University of Rochester (2) · University of Washington (2)
United States (74) · China (11) · Egypt (8) · Canada (7) · Spain (6) · South Korea (5) · Australia (3) · Netherlands (3) · Brazil (2) · Denmark (2) · France (2) · Indonesia (2) · Italy (2) · Mexico (2) · Taiwan (2)
Channing Paller, MD (2) · Daniel A Monti, MD (2) · James R. Berenson, MD (2) · Joseph J. Cullen, MD, FACS (2) · Junwen Ou, PhD (2) · Muzaffar H. Qazilbash, MD (2) · Sabine Hazan, MD (2) · Adham Mohamed, PharmD (1) · Adnan Agha (1) · Adolfo D. Rodriguez-Carrizalez, M.Sc. (1) · Akihiko Sekizawa, MD, PhD (1) · Aleksandra Simic, MD (1) · Alessandro Levis, MD (1) · Ali Al-Mousawi, MD (1)
PMID 24484547, PMID 37916745, PMID 10722036, PMID 1138591, PMID 11502226, PMID 12454520, PMID 12473574, PMID 12545007, PMID 12700374, PMID 1607900, PMID 16570523, PMID 17206944, PMID 17698683, PMID 18353115, PMID 18460663, PMID 18973181, PMID 18984888, PMID 19064521, PMID 19116389, PMID 19226361, PMID 19237716, PMID 19284416, PMID 19451353, PMID 19491213, PMID 19491386, PMID 19909499, PMID 20332511, PMID 20646908, PMID 21596735, PMID 22264303, PMID 22595020, PMID 227054, PMID 22964015, PMID 23066166, PMID 23493062, PMID 23525934, PMID 23797954, PMID 23885048, PMID 24500406, PMID 24838355, PMID 25187257, PMID 25220574, PMID 25386668, PMID 25848948, PMID 26212172, PMID 26771781, PMID 26903338, PMID 27162802, PMID 27695824, PMID 27940189
P30CA086862 (4), P01CA217797 (2), U01CA140206 (2), 1UM1HL116885-01 (1), 2008 (1), 2009 (1), 2014 (1), 2016 (1), 2018 (1), P30CA006973 (1), P30CA015083 (1), P30CA069533 (1), P50CA097274 (1), R01HL046959 (1), R01HL105447 (1)