41 completed, 11 terminated, 8 unknown, 5 withdrawn. 73 Phase 1, 26 Phase 2.
Follow Ascorbic Acid: new trials by email Literature Review of Ascorbic Acid trials Research Report on Ascorbic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| High-Dose Vitamin C in G6PDA and Pyruvate Kinase Deficiency: A Safety Study Vitamin C - Pyruvate Kinase Deficiency, Glucose 6 Phosphate Dehydrogenase Deficiency | Phase 1 | Not yet recruiting | University of Utah | 3 | 2026-07-15 | 2026-05-28 |
| High-dose Ascorbate (HDA) in Combination With Standard of Care Azacitidine and Venetoclax in Acute Myeloid Leukemia (AML) Azacitidine, Venetoclax, High-dose ascorbate - Acute Myeloid Leukemia | Phase 1 | Recruiting | Kittika Poonsombudlert | 30 | 2026-03-18 | 2026-08-31 |
| Efficacy of Microneedling With Vitamin C in Performing Gingival Depigmentation Vitamin C, Microneedling, Diode laser - Gingival Pigmentation | Phase 1 / Phase 2 | Not yet recruiting | Fayoum University | 30 | 2025-07-01 | 2025-07-17 |
| Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer Balstilimab, Biospecimen Collection, Botensilimab - Metastatic Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8 | Phase 1 | Recruiting | University of Southern California | 15 | 2025-01-15 | 2026-03-17 |
| Evaluation of Ascorbate-Meglumine Therapeutic for SRS Ascorbate-Meglumine - Safety | Phase 1 | Unknown | LadeRx LLC | 12 | 2024-09-09 | 2024-09-19 |
| A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma Ferumoxytol injection, Pharmacological ascorbate, External beam radiation therapy - Glioblastoma, Glioblastoma Multiforme | Phase 1 | Active not recruiting | Bryan Allen | 16 | 2023-02-28 | 2026-07-20 |
| Assessment of Gastric pH Changes Induced by Ascorbic Acid Tablets Omeprazole 20mg, Vitamin C - Hypochlorhydria | Phase 1 | Completed | Indiana University | 11 | 2021-10-01 | 2025-09-22 |
| High-dose Intravenous Vitamin C in Patients With Septic Shock Sodium Ascorbate - Sepsis, Severe, Septic Shock | Phase 1 | Unknown | Melbourne Health | 30 | 2021-09-27 | 2022-11-04 |
| HAT for the Treatment of Sepsis Associated With NASTI HAT, Placebo - Necrotizing Soft Tissue Infection, Sepsis | Phase 1 / Phase 2 | Terminated | Ascension Health | 10 | 2021-09-10 | 2024-07-24 |
| SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells Melphalan, BCNU, Vitamin B12B - Pancreatic Adenocarcinoma Metastatic, BRCA1 Mutation | Phase 1 | Recruiting | General Oncology, Inc. | 24 | 2021-01-13 | 2026-01-29 |
| Trial of Combination Therapy to Treat COVID-19 Infection Ivermectin, Doxycycline Hcl, Zinc - COVID, Covid-19 | Phase 1 | Completed | ProgenaBiome | 31 | 2020-12-09 | 2024-09-24 |
| Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation L-NMMA, Ketorolac, Ascorbic Acid - Hypoxia, Hypercapnia | Phase 1 | Withdrawn | University of Wisconsin, Madison | 2020-12-01 | 2019-01-10 | |
| Clinical Application of Methylene Blue for Treatment of Covid-19 Patients MCN (Methylene blue, vitamin C, N-acetyl cysteine) - Covid-19 | Phase 1 | Unknown | Mashhad University of Medical Sciences | 20 | 2020-04-19 | 2020-05-04 |
| Administration of Intravenous Vitamin C in Novel Coronavirus Infection (COVID-19) and Decreased Oxygenation L-ascorbic acid - COVID-19, Hypoxia | Phase 1 / Phase 2 | Completed | Hunter Holmes Mcguire Veteran Affairs Medical Center | 20 | 2020-04-16 | 2022-02-25 |
| The Effectiveness of High-dose Intravenous Vitamin c With Very Low Carbohydrate Diet for Terminal Colon Cancer Patients Ascorbic Acid, Control group - Colon Cancer Stage Iv | Phase 1 / Phase 2 | Unknown | National Taiwan University Hospital | 40 | 2020-01-01 | 2019-07-29 |
| Intravenous (IV) Vitamin C With Chemotherapy for Cisplatin Ineligible Bladder Cancer Patients Ascorbic Acid - Bladder Cancer | Phase 1 / Phase 2 | Active not recruiting | University of Kansas Medical Center | 12 | 2019-10-17 | 2025-03-25 |
| High Dose Ascorbate With Preoperative Radiation in Patients With Locally Advanced Soft Tissue Sarcomas Ascorbate - Soft Tissue Sarcoma | Phase 1 / Phase 2 | Completed | Mohammed Milhem | 25 | 2019-06-27 | 2026-06-18 |
| High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer Ascorbic Acid, Paclitaxel protein-bound, Cisplatin - Metastatic Pancreatic Cancer, Pancreatic Cancer | Phase 1 / Phase 2 | Withdrawn | Hitendra Patel | 2019-06-01 | 2019-06-11 | |
| High Dose Ascorbic Acid and Nanoparticle Paclitaxel Protein Bound and Cisplatin and Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer Ascorbic Acid, Paclitaxel protein-bound, Cisplatin - Metastatic Pancreatic Cancer, Pancreatic Cancer | Phase 1 / Phase 2 | Withdrawn | Medical College of Wisconsin | 2019-05-01 | 2019-05-30 | |
| High Dose Ascorbic Acid for Plasma Cell Disorders Ascorbate, Melphalan - Multiple Myeloma | Phase 1 | Completed | Christopher Strouse | 6 | 2019-03-05 | 2025-10-21 |
Showing 20 of 73. Sign in to see all of them.
Neoplasms (8) · Multiple Myeloma (7) · Pancreatic Neoplasms (7) · Glioblastoma (4) · Sepsis (4) · COVID-19 (3) · Diabetes Mellitus, Type 2 (3) · Neoplasms, Plasma Cell (3) · Obesity (3) · Shock, Septic (3) · Acute Lung Injury (2) · Asthma (2) · Breast Neoplasms (2) · Carcinoma, Non-Small-Cell Lung (2) · Colorectal Neoplasms (2)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3) · Clifford Hospital, Guangzhou, China (2) · Duke University (2) · Indiana University (2) · Jeanne Drisko, MD, CNS, FACN (2) · M.D. Anderson Cancer Center (2) · Thomas Jefferson University (2) · University of Kansas Medical Center (2) · University of Nebraska (2) · Virginia Commonwealth University (2) · Academic Emergency County Hospital Sibiu (1) · Al-Neelain University (1) · Ascension Health (1) · Barbara Ann Karmanos Cancer Institute (1) · Boston University (1)
United States (56) · Canada (2) · China (2) · Australia (1) · Egypt (1) · Germany (1) · Greece (1) · Hungary (1) · Iran (1) · Israel (1) · Romania (1) · Slovenia (1) · Spain (1) · Sudan (1) · Taiwan (1)
Jeanne Drisko, MD (2) · John M. Buatti, MD (2) · Junwen Ou, PhD (2) · Mark A Levine, M.D. (2) · Muzaffar H. Qazilbash, MD (2) · Aaron M Cypess, M.D. (1) · Adele Diamond, PhD (1) · Alpha Fowler, MD (1) · Anastasia Kotanidou, MD, PhD (1) · Arnold Glazier, M.D. (1) · Ben George, MD (1) · Brian C Davis, MD (1) · Chin-Ying Chen, MD, MHSc (1) · Christopher Lis (1) · Christopher Strouse, MD (1)
PMID 12473574, PMID 19433800, PMID 21815182, PMID 22431837, PMID 23493062, PMID 24484547, PMID 24500406, PMID 25848948, PMID 28366679, PMID 29215048, PMID 30254147, PMID 31495886, PMID 31821172, PMID 32828741, PMID 33184629, PMID 33453456, PMID 34019535, PMID 35135310, PMID 35750958, PMID 36974245, PMID 38752063, PMID 39702045, PMID 41197185, PMID 5948222
P30CA036727 (2), P01AT002620 (1), P30CA014089 (1), P30CA022453 (1), P30CA086862 (1), R01DA037285 (1), R21CA270742 (1), R21DA041596 (1), U01CA140206 (1), UL1TR002366 (1)