87 completed, 21 unknown, 6 recruiting, 5 active not recruiting. 110 Not applicable, 5 Phase 2, 3 Early Phase 1, 3 Phase 4, 2 Phase 1.
Follow Wrinkle: new trials by email Literature Review of Wrinkle trials Research Report on Wrinkle
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pre-marketing Trial to Assess Safety and Efficacy of 'Volumizing Filler Based on Hyaluronic Acid and Recombinant Collagen' Karisma - Wrinkle, Scar | Not applicable | Recruiting | Taumedika s.r.l. | 40 | 2026-11-01 | 2026-10-02 |
| Assess Injectable Hyaluronic Acid Gel for the Treatment of Volume Loss, Skin Laxity and Fine Lines Obagi® Saypha® MagIQ™ Injectable Hyaluronic Acid - Fine Lines, Wrinkle | Phase 4 | Not yet recruiting | Goldman, Butterwick, Fitzpatrick and Groff | 100 | 2026-03-01 | 2026-02-19 |
| Head-to-Head Comparison of All Botulinum Neurotoxin Type A Products for Glabellar Rhytides Botulinum toxin type A - Wrinkle, Glabellar Frown Lines | Phase 4 | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 325 | 2026-02-02 | 2026-08-14 |
| Assess Impact of Microdroplet Hyaluronic Acid Filler on Skin Quality in Patients on Glucagon-like Peptide-1 Agonists Skinvive - Wrinkle | Phase 2 | Not yet recruiting | Goldman, Butterwick, Fitzpatrick and Groff | 24 | 2025-11-01 | 2025-10-28 |
| A Prospective Controlled Study to Evaluate the Safety and Effectiveness of Thermage® FLX Radiofrequency Treatment Thermage FLX - Wrinkle, Lax Skin | Not applicable | Recruiting | Bausch Health Americas, Inc. | 164 | 2025-10-31 | 2026-08-26 |
| Efficacy of Four Topical Products to Improve Skin Longevity Face care product - Aging, Wrinkle | Not applicable | Completed | Amazentis SA | 132 | 2025-08-12 | 2025-11-17 |
| Anti-aging Efficacy of Food Supplement and Cosmetic Routine Food Supplement active, Food supplement placebo, Skin care product active - Aging, Wrinkle | Not applicable | Completed | Amazentis SA | 72 | 2025-04-23 | 2025-07-25 |
| Clinical Study to Evaluate the Efficacy and Safety of Matrix Pro Treatment Profound Matrix - Skin Laxity, Wrinkle | Not applicable | Active not recruiting | Candela Corporation | 60 | 2025-01-28 | 2026-11-02 |
| AVAVA MIRIA General Use AVAVA - Acne, Acne Scars - Mixed Atrophic and Hypertrophic | Not applicable | Recruiting | AVAVA, Inc. | 200 | 2024-09-11 | 2026-09-15 |
| The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles Topical Product: Almond Oil, Topical Product: Almond oil augmented with 0.5% Vitamin E, Topical Product: 0.025% Tretinoin oil augmented with castor oil - Collagen Degeneration, Wrinkle | Not applicable | Unknown | Integrative Skin Science and Research | 90 | 2024-07-22 | 2024-08-28 |
| Efficacy and Safety of 675-nm Laser for Dorsal Hand Rejuvenation Redtouch - Wrinkle | Not applicable | Unknown | Mahidol University | 26 | 2024-07-01 | 2024-07-08 |
| Device for Improving Skin Quality and Texture on the Face and Neck Treatment with BTL-785F - Wrinkle, Pigmentation | Not applicable | Completed | BTL Industries Ltd. | 39 | 2024-06-24 | 2025-09-16 |
| Assessing the Impact of Botulinum Toxin Type A on Facial Wrinkles: A Comprehensive Clinical Investigation Botulinum toxin type A - Wrinkle | Withdrawn | Global Aesthetics LLC | 2024-05-22 | 2026-08-12 | ||
| Healing Study of Fractional Skin Resurfacing and Tissue Histopathology After Ellacor Treatment ellacor® Micro-Coring procedure - Wrinkle, Rhytides | Not applicable | Completed | Cytrellis Biosystems, Inc. | 3 | 2024-04-30 | 2024-07-16 |
| A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction Defyne Treatment in Nasolabial Fold, RHA3 Treatment in Nasolabial Fold - Wrinkle | Not applicable | Completed | Galderma R&D | 15 | 2024-02-21 | 2026-01-16 |
| Confirmatory Study: Assessing the Efficacy and Safety of the AcusMu Microneedle Patch in Treating Periorbital Wrinkles FMD WK - Wrinkle | Completed | AcusMu Medtech Co., Ltd. | 12 | 2023-11-24 | 2024-12-04 | |
| A 56-day Clinical Study on Facial Skin Rejuvenation Fractional picosecond laser treatment followed by daily use of formulations containing MLYAAT-1002®., Fractional picosecond laser treatment followed by daily use of formulations without MLYAAT-1002® - Skin Manifestations, Wrinkle | Not applicable | Completed | Botanee Group Co., Ltd. | 24 | 2023-11-18 | 2024-08-16 |
| Safety and Efficacy of the BTL-754 Device for Laser Skin Resurfacing Treatment of the Face BTL-754-4 Treatment - Wrinkle | Not applicable | Completed | BTL Industries Ltd. | 56 | 2023-11-16 | 2024-11-14 |
| AV-23-001 AVAVA MIRIA Pilot Study MIRIA - Wrinkle, Acne Scars - Mixed Atrophic and Hypertrophic | Not applicable | Active not recruiting | AVAVA, Inc. | 200 | 2023-11-06 | 2025-03-07 |
| A Retrospective Review Evaluating the Matrix Pro Applicator for Treatment of Wrinkles Profound Matrix - Wrinkle | Completed | Candela Corporation | 32 | 2023-10-29 | 2024-10-08 |
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Cutis Laxa (18) · Acne Vulgaris (7) · Cicatrix (7) · Hypertrophy (4) · Ehlers-Danlos Syndrome (3) · Pigmentation Disorders (3) · Skin Diseases (3) · Skin Manifestations (3) · Striae Distensae (3) · Facial Expression (2) · Alopecia (1) · Dermatitis (1) · Erythema (1) · Exanthema (1) · Facies (1)
Skin and Connective Tissue Diseases (35) · Skin Diseases (31) · Connective Tissue Diseases (22) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (21) · Genetic Diseases, Inborn (21) · Skin Diseases, Genetic (21) · Pathological Conditions, Signs and Symptoms (20) · Pathologic Processes (11) · Signs and Symptoms (8) · Acneiform Eruptions (7) · Fibrosis (7) · Sebaceous Gland Diseases (7) · Pathological Conditions, Anatomical (5) · Skin Manifestations (4) · Cardiovascular Diseases (3)
Botulinum Toxins, Type A (4) · Sunscreening Agents (4) · Botulinum Toxins (2) · Injections (2) · Pharmaceutical Preparations (2) · Sodium Chloride (2) · Therapeutics (2) · Vitamin A (2) · cetyl alcohol, propylene glycol, sodium lauryl sulfate non-lipid cleansing lotion (2) · Castor Oil (1) · Chemexfoliation (1) · Collagen (1) · Cosmeceuticals (1) · Dietary Supplements (1) · Lasers (1)
BTL Industries Ltd. (14) · Revision Skincare (8) · Candela Corporation (7) · Cynosure, Inc. (7) · Integrative Skin Science and Research (6) · Goldman, Butterwick, Fitzpatrick and Groff (5) · Cytrellis Biosystems, Inc. (4) · Venus Concept (4) · AVAVA, Inc. (3) · Amazentis SA (3) · Galderma R&D (3) · I.R.A. Istituto Ricerche Applicate S.p.A. (3) · Teoxane SA (3) · University of California, Davis (3) · Botanee Group Co., Ltd. (2)
United States (90) · Israel (5) · Bulgaria (4) · China (4) · Canada (3) · Egypt (3) · Romania (3) · Germany (2) · India (2) · Italy (2) · Netherlands (2) · South Korea (2) · Spain (2) · United Kingdom (2) · Brazil (1)
Jennifer Civiok (6) · Konika Schallen, MD (3) · Matthew Gronski (3) · Emil Tanghetti (2) · Mitchel P Goldman, MD (2) · Raja Sivamani, MD (2) · Sean Doherty (2) · Adolfo Gasparetto, MD (1) · Amit Kocher, MD (1) · Anna Hardy (1) · Arielle Kauvar, MD (1) · Arielle NB Kauvar, M.D (1) · Avishai Tzur (1) · Chaitali Nangrani, MD (1)
PMID 31896400, PMID 41286587, PMID 23357983, PMID 26627306, PMID 33169920, PMID 34608092, PMID 35170772, PMID 35274096, PMID 36364354, PMID 36749255, PMID 37379470, PMID 37626137, PMID 37915337, PMID 39624736, PMID 40041776, PMID 40167796, PMID 40243133, PMID 40897963