12 completed, 7 unknown, 3 active not recruiting, 3 not yet recruiting. 18 Not applicable, 2 Phase 3, 2 Phase 4, 1 Phase 1.
Follow Vaginismus: new trials by email Literature Review of Vaginismus trials Research Report on Vaginismus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Implementing Virtual Reality Exposure Therapy for Vaginismus: From Efficacy to Clinical Integration (VIVID 3) Implementation of Virtual Reality Exposure - Vaginismus, Difficulties With Vaginal Penetration | Not applicable | Not yet recruiting | University of British Columbia | 167 | 2026-09-01 | 2026-08-05 |
| Measuring Pelvic Floor Muscle Fitness Before and After Treatment Near Infrared Imaging - Myofacial Pain, Pelvic Pain | Not applicable | Not yet recruiting | University of California, Los Angeles | 120 | 2026-09-01 | 2026-05-26 |
| Immersive Visual Modulation and Ambient Music Therapy During Transvaginal Ultrasonography in Women With Vaginismus Standard Care, Immersive Visual Modulation (IVM), Ambient Music Therapy (AMT) - Vaginismus | Not applicable | Enrolling by invitation | Demet Mutlu | 90 | 2026-07-16 | 2026-09-23 |
| Virtual Reality Exposure for Vaginismus: A Replicated Single-Case Design Virtual reality exposure - Vaginismus | Not applicable | Active not recruiting | University of British Columbia | 20 | 2025-04-01 | 2026-06-30 |
| Effectiveness of Modern Physical Agents in the Treatment of Pelvic Floor Dysfunctions modern agents rehab, classical rehab - Pelvic Floor Dysfunctions | Not applicable | Not yet recruiting | Lithuanian University of Health Sciences | 250 | 2025-03-01 | 2025-01-29 |
| Hydration and Acceptability of the Genital and Skin Mucosa of a Vaginal Moisturizer in Menopausal Women 0.20% sodium hyaluronate gel - Vaginismus, Vaginal Atrophy | Phase 3 | Unknown | Biolab Sanus Farmaceutica | 45 | 2025-03-01 | 2024-08-21 |
| VIBRating vs Traditional Therapy for Treatment of ENTry Dyspareunia Pelvic floor therapy - Genito-Pelvic Pain/Penetration Disorder, Dyspareunia | Not applicable | Recruiting | Medstar Health Research Institute | 60 | 2025-03-01 | 2025-05-21 |
| Effect of Adding Interferential Current to Pelvic Floor Muscle Training on Vaginismus Pelvic floor training, Interferential current, General advice - Vaginismus | Not applicable | Unknown | Cairo University | 30 | 2024-07-20 | 2024-07-05 |
| Prospective on Market Patient-reported Outcomes for Milli Milli Vaginal Dilator - Vaginismus, Dyspareunia | Active not recruiting | Materna Medical | 200 | 2024-05-12 | 2024-11-20 | |
| Effectiveness of Cognitive Behavioral Therapy on Psychological Distress and Problem-Solving Skills in Women With Vaginismus Cognitive Behavioral Therapy - Vaginismus, Psychological Distress | Not applicable | Completed | Delta University for Science and Technology | 60 | 2024-03-01 | 2026-05-18 |
| Pelvic Floor Physiotherapy Combined With Sexual Therapy in Vaginismus Treatment sexual therapy, Pelvic floor physiotherapy combined with sexual therapy - Women Health, Physiotherapy | Not applicable | Completed | Medipol University | 44 | 2024-01-15 | 2025-01-08 |
| Early Psychological Intervention After Rape Modified prolonged exposure - Post Traumatic Stress Disorder, Rape Sexual Assault | Not applicable | Active not recruiting | St. Olavs Hospital | 166 | 2022-06-14 | 2026-05-08 |
| Photobiomodulation for Myofascial Pelvic Pain SoLá therapy, Pelvic floor physical therapy - Pelvic Pain, Levator Ani Syndrome | Not applicable | Unknown | Orlando VA Medical Center | 28 | 2021-10-27 | 2023-07-03 |
| Feasibility of Use of Vibrators With Vaginal Dilators for Vaginismus. (Vibrator Therapy and Dilators in Vaginismus) External Vibrator - patient-administered., Standard care - Vaginismus | Not applicable | Completed | Barts & The London NHS Trust | 30 | 2021-08-11 | 2025-08-13 |
| What is the Nature of Pelvic Floor Muscle Involvement in Dyspareunia? Corticomotor excitability to the pelvic floor muscles, Pelvic floor muscle response to pressure applied at the vulvar vestibule, Pressure pain threshold (PPS) - Dyspareunia | Completed | University of Ottawa | 85 | 2021-02-02 | 2023-04-04 | |
| Trial of SVTampons vs Glass Vaginal Dilators in Treatment of Vaginismus Simple Vaginal Tampon, Glass Vaginal Trainer - Vaginismus | Not applicable | Unknown | Bezmialem Vakif University | 21 | 2020-06-01 | 2022-09-07 |
| Electrolysis Technique vs Manual Therapy in Pelvic Pain Pelvic floor manual therapy group, Pelvic floor electrolysis group - Dyspareunia, Pelvic Pain | Not applicable | Completed | Quirón Madrid University Hospital | 60 | 2017-06-20 | 2019-03-28 |
| A Trial of Pelvic Floor Chemodenervation in Patients Undergoing Physical Therapy for High Tone Pelvic Floor Dysfunction Botulinum toxin A 50u, Botulinum toxin A 100u, Botulinum toxin A 150u - Pelvic Pain, Dyspareunia | Phase 4 | Completed | EvergreenHealth | 20 | 2017-05-25 | 2021-06-10 |
| Evaluation and Comparison of Women Pelvic Floor With and Without Sexual Dysfunction (Vaginismus) Evaluation and Comparison of women pelvic floor with and without sexual dysfunction, The physiotherapeutic treatment - Vaginismus, Sexual Dysfunctions | Not applicable | Completed | Faculdade de Ciências Médicas da Santa Casa de São Paulo | 60 | 2017-02-01 | 2019-10-07 |
| Spinal Anesthesia Facilitated Sexual Intercourse As A Treatment Option For Vaginismus spinal anesthesia - Vaginismus | Not applicable | Completed | Karachi Medical and Dental College | 20 | 2017-01-01 | 2020-07-02 |
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Dyspareunia (9) · Pelvic Pain (7) · Depression (2) · Erectile Dysfunction (2) · Levator syndrome (2) · Motor Activity (2) · Sexual Dysfunction, Physiological (2) · Sexual Dysfunctions, Psychological (2) · Anxiety Disorders (1) · Coitus (1) · Constipation (1) · Dilatation, Pathologic (1) · Dystocia (1) · Facial Pain (1)
Female Urogenital Diseases (28) · Female Urogenital Diseases and Pregnancy Complications (28) · Genital Diseases (28) · Genital Diseases, Female (28) · Mental Disorders (28) · Urogenital Diseases (28) · Vaginal Diseases (28) · Sexual Dysfunction, Physiological (26) · Sexual Dysfunctions, Psychological (26) · Genital Diseases, Male (10) · Male Urogenital Diseases (10) · Pathological Conditions, Signs and Symptoms (9) · Neurologic Manifestations (8) · Signs and Symptoms (8) · Pain (7)
Botulinum Toxins, Type A (4) · Cognitive Behavioral Therapy (2) · Standard of Care (2) · Anesthesia, Spinal (1) · Botulinum Toxins (1) · Bupivacaine (1) · Crisis Intervention (1) · Electric Stimulation Therapy (1) · Nifedipine (1) · Virtual Reality Exposure Therapy (1)
University of British Columbia (2) · Abdel-Maguid Ramzy (1) · Barts & The London NHS Trust (1) · Bezmialem Vakif University (1) · Biolab Sanus Farmaceutica (1) · Cairo University (1) · Delta University for Science and Technology (1) · Demet Mutlu (1) · EvergreenHealth (1) · Faculdade de Ciências Médicas da Santa Casa de São Paulo (1) · Hillel Yaffe Medical Center (1) · Imperial College London (1) · Karachi Medical and Dental College (1) · Lithuanian University of Health Sciences (1) · Materna Medical (1)
United States (8) · Canada (3) · Turkey (Türkiye) (3) · Egypt (2) · United Kingdom (2) · Brazil (1) · Iran (1) · Israel (1) · Lithuania (1) · Norway (1) · Spain (1)
AbdelMaguid I Ramzy, MD (1) · Basma W Elrefay, PhD (1) · Carolina Walker, PT, PhD (1) · Cecilie T Hagemann (1) · Cheryl Iglesia, MD (1) · Christoph Lees, MD MRCOG (1) · Daniel Biller, MD (1) · Doaa A. Osman, PHD (1) · Eyal Shif, Prof. MD (1) · Hila Sharabi, M.D (1) · Jess Gaddie (1) · Linda McLean (1)
PMID 15089868, PMID 17195176, PMID 19222415, PMID 28363809, PMID 31551840, PMID 34697691, PMID 36810120, PMID 39223617, PMID 39773406, PMID 40673454
R61AT013008 (1)