10 completed, 3 recruiting, 3 unknown. 16 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 16 | Completed 10, Recruiting 3, Unknown 3 |
Follow Typhoid Fever: new trials by email Literature Review of Typhoid Fever trials Research Report on Typhoid Fever
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| This Randomized Controlled Trial Evaluates the Comparative Efficacy of Intravenous Meropenem Alone Versus Intravenous Meropenem Combined With Oral Azithromycin in Children Aged 6 Months to Under 5 Years Diagnosed With Blood Culture-confirmed Extensively Drug-resistant Uncomplicated Typhoid Fever Meropenem, Azithromycin + Metronidazole - Extensively Drug-Resistant Typhoid Fever, Typhoid Fever | Phase 4 | Completed | Sheikh Zayed Medical College | 90 | 2025-05-14 | 2026-03-03 |
| Meropenem vs Azithromycin Efficacy in Case XDR Enteric Fever Azithromycin, Meropenem Injection - Enteric Fever | Phase 4 | Recruiting | Indus Hospital and Health Network | 40 | 2025-04-22 | 2026-05-08 |
| Immune Response Elicited by Concomitant Administration of Oral Typhoid Fever (Vivotif®) and Cholera (Dukoral®) Vaccines Oral typhoid fever vaccine, Oral cholera vaccine - Vaccine-Preventable Diseases, Typhoid Fever | Phase 4 | Completed | Helsinki University Central Hospital | 65 | 2023-10-25 | 2024-12-05 |
| Typhoid Conjugate Vaccine Introduction in Madagascar (TyMA): Evaluation of the Real-World Effectiveness of the Vi-CRM197 Typhoid Conjugate Vaccine in Madagascar Biological/Vaccine - Vi-CRM197 TCV - Salmonella Typhi Infection, Typhoid Fever | Phase 4 | Recruiting | Rita Soares Barbosa Cardona | 60000 | 2023-07-23 | 2026-11-12 |
| Vellore Typhoid Vaccine Impact Trial Typhoid conjugate Vaccine - Typhoid Fever | Phase 4 | Completed | Christian Medical College, Vellore, India | 72400 | 2023-05-01 | 2026-03-17 |
| Effectiveness of a Typhoid Conjugate Vaccine in DRC Vi-TT - Typhoid Fever | Phase 4 | Unknown | International Vaccine Institute | 48000 | 2022-02-11 | 2023-04-18 |
| Evaluation of Typhoid Conjugate Vaccine Effectiveness in Ghana Vi-TT, MCV-A vaccine - Typhoid Fever | Phase 4 | Unknown | International Vaccine Institute | 23000 | 2021-08-24 | 2024-03-08 |
| The Azithromycin and Cefixime Treatment of Typhoid in South Asia Trial (ACT-South Asia Trial) Azithromycin, Cefixime, Placebo - Typhoid Fever | Phase 4 | Completed | Oxford University Clinical Research Unit, Vietnam | 2150 | 2021-05-23 | 2026-01-15 |
| Comparison of Two Drugs Regimen in Treatment of Complicated Typhoid Fever in Children Meropenem Injection, Azithromycin Powder - Typhoid Fever | Phase 4 | Completed | Ziauddin University | 126 | 2019-06-20 | 2021-06-16 |
| Typhoid Fever: Combined vs. Single Antibiotic Therapy ceftriaxone, ceftriaxone and azithromycin, azithromycin - Typhoid Fever | Phase 4 | Unknown | Sheba Medical Center | 120 | 2013-08-01 | 2014-08-27 |
| Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever Ceftriaxone, Gatifloxacin - Enteric Fever, Typhoid Fever | Phase 4 | Completed | Oxford University Clinical Research Unit, Vietnam | 300 | 2011-09-01 | 2016-10-04 |
| Blood Donor CVD 5000 Vivotif Typhoid Oral Vaccine - Risk Reduction | Phase 4 | Recruiting | University of Maryland, Baltimore | 150 | 2004-01-16 | 2026-03-27 |
| Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever Typhoid Vi vaccine, Hepatitis A vaccine - Typhoid, Paratyphoid Fever | Phase 4 | Completed | International Vaccine Institute | 37673 | 2003-05-01 | 2008-08-26 |
| Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam Typhoid Vi vaccine, Hepatitis A (control) - Typhoid, Paratyphoid Fever | Phase 4 | Completed | International Vaccine Institute | 100742 | 2001-12-01 | 2008-03-13 |
| Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China Typhoid Vi vaccine, Meningococcal A (control) - Typhoid, Paratyphoid Fever | Phase 4 | Completed | International Vaccine Institute | 96468 | 2001-10-01 | 2008-03-13 |
| Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in Childhood Typhoid Vi vaccine, Hepatitis A vaccine - Typhoid, Paratyphoid Fever | Phase 4 | Completed | International Vaccine Institute | 27231 | 2001-10-01 | 2008-08-26 |
Paratyphoid Fever (4) · Cholera (1) · Risk Reduction Behavior (1) · Salmonella Infections (1) · Vaccine-Preventable Diseases (1)
Bacterial Infections (16) · Bacterial Infections and Mycoses (16) · Enterobacteriaceae Infections (16) · Gram-Negative Bacterial Infections (16) · Infections (16) · Salmonella Infections (15) · Behavior (1) · Vibrio Infections (1)
Azithromycin (4) · Vi polysaccharide vaccine, typhoid (4) · Hepatitis A Vaccines (3) · Meropenem (3) · Cefixime (2) · Ceftriaxone (2) · Biological Products (1) · Cholera Vaccines (1) · Dukoral (1) · Gatifloxacin (1) · Metronidazole (1) · Ty21a typhoid vaccine (1)
International Vaccine Institute (6) · Oxford University Clinical Research Unit, Vietnam (2) · Christian Medical College, Vellore, India (1) · Helsinki University Central Hospital (1) · Indus Hospital and Health Network (1) · Rita Soares Barbosa Cardona (1) · Sheba Medical Center (1) · Sheikh Zayed Medical College (1) · University of Maryland, Baltimore (1) · Ziauddin University (1)
Pakistan (4) · Nepal (3) · India (2) · China (1) · Democratic Republic of the Congo (1) · Finland (1) · Ghana (1) · Madagascar (1) · United States (1) · Vietnam (1)
Florian Marks, PhD (2) · Anu Kantele, MD, PhD (1) · Buddha Basnyat, MBBS,Msc,MD (1) · Buddha Basnyat, MD (1) · Canh G Do, MD (1) · Dong Baiqing, MD (1) · Eli Schwartz, MD, DTMH (1) · Ellis Owusu Dabo, PhD (1) · Gagandeep Kang, MD PhD (1) · Jacob John, MD PhD (1) · Octavie Lunguya, PhD (1) · Sujit K Bhatttacharya, MD (1) · Zulfiqar A Bhutta, MBBS, PhD (1)
PMID 10348767, PMID 17145784, PMID 18493312, PMID 19625715, PMID 22718054, PMID 26809813, PMID 29684022, PMID 35097222, PMID 42624818