10 completed, 1 not yet recruiting, 1 recruiting, 1 terminated. 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 1 | Completed 1 |
Follow Trisomy 18: new trials by email Literature Review of Trisomy 18 trials Research Report on Trisomy 18
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hematological Profile in Children With Numerical Chromosomal Disorders Down Syndrome, Turner Syndrome | Not yet recruiting | Assiut University | 158 | 2026-09-02 | 2026-09-10 | |
| The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment Pregnant Individuals, Aneuploidy | Recruiting | BillionToOne Inc. | 1000 | 2026-01-10 | 2026-10-15 | |
| Verification of Risk Assignment for Whole Chromosome Using SNP-based NIPT in Vanishing Twin Pregnancies Vanishing Twin, Trisomy 21 | Completed | Natera, Inc. | 136 | 2021-07-22 | 2026-08-17 | |
| Study of Vanadis® NIPT for Non-invasive Prenatal Screening of Trisomies (T21, T18 and T13) Vanadis NIPT system - Trisomy 21, Trisomy 18 | Unknown | PerkinElmer, Wallac Oy | 1200 | 2018-06-20 | 2018-08-29 | |
| VAlidation of a Lower Cost aneUploidy scrEen SmartNIPT - Down Syndrome, Trisomy 18 | Completed | Women and Infants Hospital of Rhode Island | 2443 | 2017-10-10 | 2022-09-22 | |
| SNP-based Microdeletion and Aneuploidy RegisTry (SMART) 22q11 Deletion Syndrome, DiGeorge Syndrome | Completed | Natera, Inc. | 20960 | 2015-04-01 | 2021-01-29 | |
| High Risk Multiple Gestation Study Trisomy 13, Trisomy 18 | Completed | Natera, Inc. | 99 | 2014-08-01 | 2019-06-13 | |
| Prenatal Screening for Down Syndrome With DNAFirst Trisomy 21, Trisomy 18 | Completed | Women and Infants Hospital of Rhode Island | 100 | 2014-06-01 | 2018-02-22 | |
| Non-Invasive Chromosomal Evaluation of Trisomy Study Aneuploidy, Trisomy 21 | Completed | Cindy Cisneros | 2000 | 2014-04-01 | 2020-04-30 | |
| Study of the Efficacy of New Non-invasive Prenatal Tests for Screening for Fetal Trisomies Using Maternal Blood Integrated prenatal screening for Down's syndrome, Serum QUAD Assay for aneuploidy screening, Semiconductor MPSS NIPT assay using ccfDNA in maternal blood - Trisomy 21, Trisomy 18 | Not applicable | Completed | CHU de Quebec-Universite Laval | 3819 | 2013-11-01 | 2018-02-22 |
| Multiple Gestation Study Trisomy 13, Trisomy 18 | Completed | Natera, Inc. | 354 | 2013-03-01 | 2019-08-26 | |
| Development of Non-invasive Prenatal Screening Test for Microdeletions Based on Fetal DNA Isolated From Maternal Blood Trisomy 21, Trisomy 18 | Completed | Natera, Inc. | 1059 | 2012-11-01 | 2020-12-30 | |
| Development of Non-invasive Prenatal Test for Microdeletion and Other Genetic Syndromes Based on Cell Free DNA Microdeletion Syndromes, Trisomy 21 | Completed | Natera, Inc. | 216 | 2012-10-01 | 2019-08-26 | |
| Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial Blood Draw - Trisomy 13, Trisomy 18 | Terminated | Natera, Inc. | 937 | 2012-01-01 | 2023-03-23 |
Down Syndrome (14) · Trisomy 18 Syndrome (14) · Trisomy 13 Syndrome (13) · Turner Syndrome (8) · Sex Chromosome Aberrations (6) · Aneuploidy (4) · Chromosome Disorders (2) · DiGeorge Syndrome (2) · Klinefelter Syndrome (2) · Trisomy (2) · 22q11 Deletion Syndrome (1) · Angelman Syndrome (1) · Chromosome 1p36 Deletion Syndrome (1) · Cri-du-Chat Syndrome (1) · Patient Satisfaction (1)
Abnormalities, Multiple (14) · Cardiovascular Abnormalities (14) · Cardiovascular Diseases (14) · Congenital Abnormalities (14) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (14) · Genetic Diseases, Inborn (14) · Heart Defects, Congenital (14) · Heart Diseases (14) · Intellectual Disability (14) · Nervous System Diseases (14) · Neurobehavioral Manifestations (14) · Neurologic Manifestations (14) · Chromosome Disorders (12) · Endocrine System Diseases (9) · Chromosome Aberrations (8)
Natera, Inc. (7) · Women and Infants Hospital of Rhode Island (2) · Assiut University (1) · BillionToOne Inc. (1) · CHU de Quebec-Universite Laval (1) · Cindy Cisneros (1) · PerkinElmer, Wallac Oy (1)
United States (11) · Canada (3) · Italy (3) · Spain (3) · Ireland (2) · Australia (1) · India (1) · Malaysia (1) · South Korea (1) · Sweden (1) · Taiwan (1) · United Kingdom (1)
Glenn E Palomaki, PhD (2) · Peer Dar, MD (2) · Brian Kirshon, MD (1) · Enza Pavanello (1) · Errol Norwitz, MD, PhD (1) · Francois Rousseau, MD MSc FRCPC (1) · Joanne Stone, MD (1) · Julia Wynn, MS, MS, CGC (1) · Kim Martin, MD (1) · Lorraine Dugoff, MD (1) · Mary Norton, MD (1) · Mohamed M Hamdy, prof (1) · Rajeevi Madankumar, MD (1) · Robert Carpenter, MD (1) · Robert Lamar Parker, MD (1)
PMID 10417280, PMID 12820840, PMID 16814942, PMID 20375405, PMID 21310373, PMID 21519036, PMID 22005709, PMID 22281937, PMID 22464072, PMID 22617594, PMID 22742782, PMID 23215555, PMID 23613152, PMID 23712453, PMID 24135152, PMID 24388429, PMID 24785862, PMID 25004354, PMID 25111587, PMID 25479548, PMID 25834952, PMID 28079901, PMID 31231136, PMID 34761647, PMID 35033576, PMID 35085538, PMID 36103259, PMID 36965866, PMID 9647154
R44HD062114 (1)