27 completed, 16 recruiting, 12 unknown, 5 not yet recruiting. 36 Not applicable, 5 Phase 1, 5 Phase 2, 2 Early Phase 1, 1 Phase 4.
Follow Thoracic Cancer: new trials by email Literature Review of Thoracic Cancer trials Research Report on Thoracic Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MINTER Trial: Metal Intervention aNd ThErapy With Radiotherapy In Thoracic Cancer Using Copper Donor Therapy: A Phase 2, Open-Label Study Disulfiram 250 mg, Copper Gluconate 2 mg, Radiation Therapy - Thoracic Cancer | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 30 | 2027-03-01 | 2026-09-28 |
| TNG462-C103: Study to Evaluate the Safety, Tolerability, and Antitumor Activity of Vopimetostat in Combination With ERAS-0015 in PDAC and NSCLC Patients vopimetostat, ERAS-0015 - PDAC, PDAC - Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Not yet recruiting | Tango Therapeutics, Inc. | 188 | 2026-11-01 | 2026-10-27 |
| Immune Checkpoint Inhibitor (ICI)-Drug-Drug Interaction (DDI) Study ICI Therapy - Gastrointestinal Neoplasms, Genitourinary Cancer | Early Phase 1 | Not yet recruiting | Indiana University | 80 | 2026-09-01 | 2026-07-15 |
| Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease Atorvastatin and Lisinopril, Placebo - Chest Wall Tumor, Breast Cancer | Phase 2 | Recruiting | UNC Lineberger Comprehensive Cancer Center | 60 | 2026-08-12 | 2026-09-17 |
| Ph. I/II Sodium Thiosulfate for OtoProtection During Cisplatin (STOP-CIS) Pedmark® STS - Solid Tumor Malignancies, Testicular Cancer | Phase 1 / Phase 2 | Recruiting | University of Arizona | 25 | 2026-05-18 | 2026-06-18 |
| LUCINAE Registry: Thoracic Cancers During Pregnancy Lung Cancer, Thoracic Cancer | Recruiting | Oncology Institute of Southern Switzerland | 100 | 2026-04-23 | 2026-10-21 | |
| SCINTIX [BgRT} Using RMRS in Solid and Soft Tissue Tumors RefleXion X1 Radiotherapy System [Imaging Only] - Thoracic Cancer, Head and Neck Cancer | Not applicable | Not yet recruiting | RefleXion Medical | 96 | 2025-12-01 | 2025-08-13 |
| Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM) Cohort A: Extensive Stage Small Cell Lung Cancer (ES-SCLC) Thoracic Tumor PULSAR (Personalized ultrahypofractionated stereotactic ablative radiotherapy), Cohort B: Brain metastasis PULSAR (Personalized ultrahypofractionated stereotactic ablative radiotherapy), Cohort C: Sarcoma Pre-Operative PULSAR - Small Cell Lung Cancer Extensive Stage, Brain Metastases | Phase 1 | Recruiting | University of Texas Southwestern Medical Center | 105 | 2025-10-28 | 2026-08-17 |
| Curatively Intended Thoracic Reirradiation Radiotherapy - Radiotherapy Side Effect, Radiation Toxicity | Recruiting | University of Aarhus | 500 | 2025-10-10 | 2026-03-04 | |
| Qualitative Study on Detection & Tx of NSCLC in Pts w/ a History of Alcohol or SUD Non-Interventional Study - Lung Non-Small Cell Carcinoma, Thoracic Cancer | Recruiting | University of Southern California | 45 | 2025-09-29 | 2026-09-22 | |
| Prospective Data Collection Initiative on Thoracic Malignancies Health-related quality of life and treatment outcome questionnaires, (Tumor) tissue and other biomaterials, Blood samples - Lung Cancer, Thoracic Cancer | Recruiting | Dutch Society of Physicians for Pulmonology and Tuberculosis | 12000 | 2025-08-15 | 2026-07-07 | |
| Variability and Post-op AEs: Does Preoperative CardioPulmonary Variability Assessment Identify Risk of Postoperative Adverse Events Following Thoracic Surgery CardioPulmonary Variability Assessment - Thoracic Cancer, Complication,Postoperative | Recruiting | Ottawa Hospital Research Institute | 130 | 2025-07-01 | 2026-05-01 | |
| Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients TNG462, RMC-9805, RMC-6236 - PDAC, PDAC - Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | Tango Therapeutics, Inc. | 183 | 2025-05-31 | 2026-10-23 |
| Thoracic Surgery by the Medtronic Hugo™ Robotic System Medtronic Hugo™ surgical robotic system - Thoracic Cancer | Recruiting | Chinese University of Hong Kong | 50 | 2025-05-01 | 2026-10-21 | |
| Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT Blood Specimen Collection, Stool Specimen Collection, Quality of Life (QOL) Questionnaires - Cancer, Thoracic Cancer | Recruiting | University of California, San Francisco | 125 | 2024-12-27 | 2026-09-15 | |
| Reirradiation Dose Escalation in Thoracic Cancers stereotactic body radiation therapy (SBRT) - Thoracic Cancer, Lung Cancer | Phase 1 | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 48 | 2024-10-30 | 2024-08-16 |
| Evaluation of On-Couch CBCT Image Quality HyperSight Imaging - Head and Neck Cancer, Thoracic Cancer | Not applicable | Completed | Varian, a Siemens Healthineers Company | 46 | 2024-10-17 | 2026-05-06 |
| Validate the Safety and Feasibility of the CT-guided Interventional Robot in Percutaneous Lung Cryablation Procedures CT-fluoroscopy guided master-slave intervetional robot-assisted lung Cryoablation - Lung Cancer, Thoracic Cancer | Not applicable | Unknown | Tianjin Medical University Cancer Institute and Hospital | 20 | 2024-09-15 | 2024-09-03 |
| SPSIPB vs SAPB for Thoracoscopic Surgery SPSIPB blcok, SAPB block, Postoperative analgesia management - Lung Diseases, Lung Cancer | Not applicable | Completed | Medipol University | 46 | 2024-08-10 | 2026-09-17 |
| Patient-Generated Health Data Collection During Chemoradiotherapy for Lung Cancer Proton Beam Radiation with or without concurrent chemotherapy - Thoracic Cancer | Recruiting | The New York Proton Center | 40 | 2024-03-22 | 2026-04-13 |
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Lung Neoplasms (17) · Gastrointestinal Neoplasms (11) · Breast Neoplasms (10) · Head and Neck Neoplasms (10) · Neoplasms (6) · Sarcoma (6) · Carcinoma, Non-Small-Cell Lung (5) · Melanoma (5) · Thoracic Neoplasms (5) · Esophageal Neoplasms (4) · Pelvic Neoplasms (4) · Postoperative Complications (4) · Urogenital Neoplasms (4) · Prostatic Neoplasms (3) · Thoracic Diseases (3)
Neoplasms by Site (49) · Neoplasms (43) · Respiratory Tract Diseases (23) · Respiratory Tract Neoplasms (21) · Lung Diseases (20) · Thoracic Neoplasms (18) · Digestive System Diseases (16) · Digestive System Neoplasms (16) · Gastrointestinal Diseases (16) · Skin Diseases (15) · Skin and Connective Tissue Diseases (15) · Neoplasms by Histologic Type (13) · Breast Diseases (11) · Pathological Conditions, Signs and Symptoms (11) · Urogenital Diseases (11)
Radiosurgery (3) · Radiotherapy (3) · Blood Specimen Collection (2) · Quality of Life (2) · Advance Care Planning (1) · Advance Directives (1) · Analgesia, Patient-Controlled (1) · Atorvastatin (1) · Data Collection (1) · Disulfiram (1) · Drug Therapy (1) · Gluconates (1) · Histocompatibility Testing (1) · Lisinopril (1) · Magnetic Resonance Imaging (1)
University of Texas Southwestern Medical Center (4) · Memorial Sloan Kettering Cancer Center (3) · Dana-Farber Cancer Institute (2) · Indiana University (2) · Peking University Third Hospital (2) · Tango Therapeutics, Inc. (2) · The New York Proton Center (2) · Tianjin Medical University Cancer Institute and Hospital (2) · University of Maryland, Baltimore (2) · Varian, a Siemens Healthineers Company (2) · Washington University School of Medicine (2) · AHEPA University Hospital (1) · Aarhus University Hospital (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1)
United States (33) · China (6) · Canada (5) · Denmark (3) · Switzerland (3) · Egypt (2) · Italy (2) · United Kingdom (2) · Belgium (1) · France (1) · Greece (1) · Hong Kong (1) · Israel (1) · Netherlands (1) · Singapore (1)
Alejandro Recio-Boiles, MD (1) · Alessio G Morganti, MD (1) · Alfonso Fiorelli, MD, PhD (1) · Amit Sawant, PhD (1) · Andrew JE Seely, MD, PhD, FRSCS (1) · Bin Xiong, MD, PhD (1) · Brooks V Udelsman (1) · Calvin Sze Hang Ng (1) · Carmen Bergom, M.D., Ph.D. (1) · Changhong Miao (1) · Cheng He, PhD (1) · Christian Fankhauser, PD Dr. med. (1) · Christopher Manz, MD (1) · David Palma, MD,PhD,FRCPC (1) · David Parsons, PHD (1)
PMID 31452053, PMID 31463699, PMID 31647691, PMID 34195486, PMID 34586461, PMID 34985914, PMID 35522464, PMID 35651964, PMID 36038883, PMID 36600389, PMID 38011613, PMID 38020116, PMID 38445744, PMID 38546897, PMID 39423043, PMID 39486014, PMID 39533260, PMID 39809874, PMID 40257368, PMID 40524282, PMID 40631021, PMID 41543884, PMID 41941188, PMID 41997702, PMID 42026560, PMID 42444902
1UM1CA233080-01 (1), K23GM147805 (1), P30CA014089 (1), R37CA233774 (1), U10CA101178 (1)