47 recruiting, 23 not yet recruiting, 7 completed, 5 unknown. 29 Phase 1, 15 Not applicable, 14 Phase 2, 12 Early Phase 1, 2 Phase 3.
Follow Systemic Sclerosis (SSc): new trials by email Literature Review of Systemic Sclerosis (SSc) trials Research Report on Systemic Sclerosis (SSc)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy, in Participants With Systemic Sclerosis (SSc) Refractory to Standard Therapy C-CAR168 - Systemic Sclerosis (SSc), Systemic Sclerosis | Phase 1 | Not yet recruiting | AbelZeta Inc. | 12 | 2027-03-01 | 2026-10-13 |
| Safety and Preliminary Efficacy of HN2302 in Patients With Autoimmune Diseases HN2302 Injection - Autoimmune Disease, Systemic Lupus Erythematosus | Phase 1 | Not yet recruiting | Shenzhen MagicRNA Biotechnology Co., Ltd | 12 | 2026-12-31 | 2026-08-12 |
| Mycophenolate After Stem Cell Transplant for Systemic Sclerosis Mycophenolate Mofetil 1000 mg twice daily - Systemic Sclerosis (SSc) | Phase 2 | Not yet recruiting | Ottawa Hospital Research Institute | 6 | 2026-12-01 | 2026-10-19 |
| Study Investigating the Safety of Anti-CD19 CAR-T Cells Therapy Produced at Gustave Roussy for Adults With Severe and Refractory Systemic Autoimmune Rheumatic Diseases anti-CD19 CAR-T cells - Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE) | Phase 1 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 6 | 2026-12-01 | 2026-09-02 |
| Investigation of Type I Interferon Excess in Patients With Systemic Autoimmune Diseases and Genetic Type I Interferonopathies biological samples - Systememic Lupus Erythematosus, Systemic Sclerosis (SSc) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 120 | 2026-12-01 | 2026-09-24 |
| A Phase 1 Study of QLS2416 Injection in Participants With Autoimmune Diseases QLS2416 Injection - Systemic Lupus Erythematosus, Rheumatoid Arthritis (RA) | Phase 1 | Not yet recruiting | Shanghai Qilu Pharmaceutical Research and Development Center LTD | 76 | 2026-12-01 | 2026-10-30 |
| Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases anti-CD19 CAR-T cells - Systemic Lupus Erthematosus, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Not yet recruiting | Peking University Third Hospital | 9 | 2026-11-01 | 2026-09-23 |
| Tissue Modeling in Systemic Sclerosis Using Induced Pluripotent Stem Cells (iPSCs) Blood Sample Collection - Systemic Sclerosis (SSc) | Not applicable | Recruiting | University Hospital, Montpellier | 16 | 2026-10-27 | 2026-10-29 |
| Home-based Exercise for Improving Health-related Quality of Life in Systemic Sclerosis Home-based exercise programme, Usual Care - Systemic Sclerosis (SSc) | Not applicable | Not yet recruiting | University of Aarhus | 270 | 2026-10-15 | 2026-09-25 |
| Combined Growth Differentiation Factor-15 (GDF-15) and Lung Ultrasound for ILD Screening in Rheumatoid Arthritis and Systemic Sclerosis Lung ultrasound, GDF-15 level (ELISA), CT scan - Rheumatoid Arthritis (RA), Systemic Sclerosis (SSc) | Not yet recruiting | Assiut University | 110 | 2026-10-15 | 2026-09-25 | |
| Nebulized UC-EVs for Recurrent or Refractory IMIDs With Lung Involvement nebulized human umbilical cord mesenchymal stromal cell-derived extracellular vesicles - IgG4 Related Disease, Systemic Sclerosis (SSc) | Early Phase 1 | Not yet recruiting | Qiubai Li | 18 | 2026-10-14 | 2026-09-08 |
| BAFF CAR-T Cells (LMY-922) for Treatment of Refractory Autoimmune Disease LMY-922 - Rheumatoid Arthritis (RA), Systemic Lupus Erthematosus (SLE) | Phase 1 | Not yet recruiting | Luminary Therapeutics | 94 | 2026-10-01 | 2026-07-28 |
| FT839 in Autoimmune Diseases FT839 - ANCA-Associated Vasculitis (AAV), Idiopathic Inflammatory Myositis (IIM) | Phase 1 / Phase 2 | Recruiting | Fate Therapeutics | 446 | 2026-10-01 | 2026-09-02 |
| A Study of ATG-201 in Adult Participants With Autoimmune Diseases ATG-201 - Systemic Lupus Erythematosus, Systemic Sclerosis (SSc) | Phase 1 | Recruiting | Antengene Biologics Limited | 149 | 2026-09-26 | 2026-10-28 |
| TL1A Inhibition in Systemic Sclerosis-Related Skin Fibrosis and Immunological Alterations: A Proof-of-Concept In Vitro Study (FIBROSTOP) TL1A stimulation and inhibition (in vitro) - Systemic Sclerosis (SSc), Diffuse Cutaneous Systemic Sclerosis | Not yet recruiting | Fondazione Policlinico Universitario Campus Bio-Medico | 20 | 2026-09-01 | 2026-06-11 | |
| A Phase II Study of TollB-001 Tablets in Systemic Sclerosis TollB-001 Tablet, Placebo - Systemic Sclerosis (SSc) | Phase 2 | Not yet recruiting | Toll Biotech Co. Ltd. (Beijing) | 36 | 2026-08-01 | 2026-08-04 |
| Efficacy of A Non-Invasive Botulinum Toxin Microneedle Pad for the Treatment of Secondary Raynaud's Phenomenon Botulinum toxin A via microneedle, Control (Normal saline) - Systemic Sclerosis (SSc), Raynaud Disease Secondary to Scleroderma | Phase 3 | Not yet recruiting | Khon Kaen University | 72 | 2026-08-01 | 2026-08-17 |
| US Zamto-cel Autoimmune Diseases zamtocabtagene autoleucel, Cyclophosphamide, Fludarabine - Lupus Nephritis, Systemic Lupus Erythematosus | Phase 1 | Recruiting | Miltenyi Biomedicine GmbH | 48 | 2026-07-01 | 2026-06-11 |
| Personalized Online Occupational Therapy Intervention for Adults With Scleroderma Personalized Online Occupational Therapy Intervention, Usual Care - Scleroderma, Scleroderma (Limited and Diffuse) | Not applicable | Completed | Universidad de Zaragoza | 24 | 2026-05-16 | 2026-10-14 |
| CD19/BCMA UCAR-T for B Cell-Related Autoimmune Disease QT-219CX - Autoimmune Diseases, Systemic Lupus Erthematosus (SLE) | Early Phase 1 | Recruiting | The Children's Hospital of Zhejiang University School of Medicine | 15 | 2026-05-08 | 2026-05-14 |
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Scleroderma, Systemic (92) · Lupus Erythematosus, Systemic (26) · Myositis (25) · Scleroderma, Diffuse (20) · Arthritis, Rheumatoid (19) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (17) · Autoimmune Diseases (15) · Sjogren's Syndrome (13) · Antiphospholipid Syndrome (9) · Dermatomyositis (7) · Lupus Nephritis (6) · Arthritis, Juvenile (4) · Arthritis, Psoriatic (4) · Multiple Sclerosis (4) · Glomerulonephritis, IGA (3)
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