7 completed, 5 recruiting, 4 unknown, 3 not yet recruiting. 7 Not applicable, 5 Phase 2, 3 Phase 1, 1 Early Phase 1, 1 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Intracochlear Injection of Glucocorticoid Through the Round Window Membrane in Patients With Profound or Complete Sudden Sensorineural Hearing Loss intracochlear injection of triamcinolone acetonide through the round window membrane, intratympanic dexamethasone injection through the tympanic membrane - Sudden Hearing Loss | Phase 2 | Not yet recruiting | Eye & ENT Hospital of Fudan University | 56 | 2026-09-15 | 2026-09-11 |
| Trans-round Window Membrane Intracochlear Steroid Experimental: Group A: intracochlear triamcinolone acetonide injection, intracochlear injection of dexamethasone, intratympanic dexamethasone injection - Sudden Hearing Loss | Phase 2 | Not yet recruiting | Eye & ENT Hospital of Fudan University | 108 | 2026-04-20 | 2026-04-20 |
| Regenerative Medicine and Stem Cell-Based Interventions for Inner Ear Trauma, Tinnitus, and Sensorineural Hearing Loss Audiologic Monitoring, Investigational Regenerative Pharmacologic Therapy, Stem Cell Regenerative Therapy - Sensorineural Hearing Loss, Tinnitus | Early Phase 1 | Enrolling by invitation | Truway Health, Inc. | 120 | 2026-03-08 | 2026-03-16 |
| Study on the Safety and Efficacy of Intratympanic Injection of Small Extracellular Vesicles Derived From Mesenchymal Stem Cells in Severe and Profound Sudden Sensorineural Hearing Loss Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at low doses, Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at moderate doses, Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at high doses - Sudden Hearing Loss, Extracellular Vesicles | Phase 1 / Phase 2 | Not yet recruiting | The Affiliated Hospital of Qingdao University | 9 | 2026-02-28 | 2026-03-25 |
| Yiyuancong for the Treatment of Sudden Sensorineural Hearing Loss Standard treatment combined with Yiyuancong, Standard treatment - Sudden Hearing Loss, Sensorineural Hearing Loss | Not applicable | Recruiting | Guangdong Provincial People's Hospital | 128 | 2025-11-15 | 2026-04-01 |
| Efficacy and Safety of Hydroxychloroquine in the Treatment of Sudden Sensorineural Hearing Loss Hydroxychloroquine, Steroid - Sudden Hearing Loss | Phase 2 | Recruiting | Chang Gung Memorial Hospital | 80 | 2024-09-10 | 2026-10-22 |
| Effectiveness of Integrative Medical Treatment in Sudden Hearing Loss Acupuncture, steroid therapy - Sudden Hearing Loss | Not applicable | Recruiting | China Medical University Hospital | 64 | 2024-07-08 | 2025-11-19 |
| FX-322 in Adults With Acquired Sensorineural Hearing Loss FX-322, Placebo - Hearing Loss, Sensorineural, Noise Induced Hearing Loss | Phase 2 | Completed | Frequency Therapeutics | 142 | 2021-10-12 | 2023-04-21 |
| Sudden Sensorineural Hearing Loss in Wonju Severance Christian Hospital SSNHL(Sudden Sensory Neural Hearing Loss), Sudden Hearing Loss | Recruiting | Wonju Severance Christian Hospital | 1000 | 2021-07-14 | 2025-03-26 | |
| FX-322 in Adults With Severe Sensorineural Hearing Loss FX-322, Placebo - Hearing Loss, Sensorineural, Noise Induced Hearing Loss | Phase 1 | Completed | Frequency Therapeutics | 31 | 2020-11-02 | 2022-02-01 |
| FX-322 in Adults With Age-Related Sensorineural Hearing Loss FX-322, placebo - Presbycusis, Hearing Loss, Sensorineural | Phase 1 | Completed | Frequency Therapeutics | 30 | 2020-09-17 | 2022-05-25 |
| The Effect of Patient's Position After Intra-tympanic Injection on the Amount of Fluid in the Middle Ear Sitting after intra tympanic injection - Sudden Hearing Loss | Not applicable | Unknown | Tel-Aviv Sourasky Medical Center | 20 | 2020-08-01 | 2020-06-29 |
| Use of Vibration Anesthesia Device in Intratympanic Injections Vibration Anesthesia Device (VAD), local anesthetic cream, lidocaine spray - Intratympanic Injections, Sudden Hearing Loss | Not applicable | Completed | Yuzuncu Yil University | 40 | 2020-07-25 | 2025-03-20 |
| The Effect of Patient's Position After Intra-tympanic Injection Change of posture after Intra Tympanic injection - Sudden Hearing Loss | Unknown | Tel-Aviv Sourasky Medical Center | 20 | 2020-07-01 | 2020-05-12 | |
| The Effect of PAP on ISSHL Comorbided With OSA non-invasive positive airway pressure, Methylprednisolone Hemisuccinate, Ginaton - Sudden Hearing Loss, Obstructive Sleep Apnea | Phase 4 | Recruiting | Beijing Tsinghua Chang Gung Hospital | 102 | 2019-11-01 | 2019-12-10 |
| Vestibular Prognosis Assessment of ISSNHL With Vestibular Dysfunction Treated With Oral or Intratympanic Glucocorticoids Prednisone 5Mg Tab, Methylprednisolone 40 mg - Vestibular Vertigo, Sudden Hearing Loss | Not applicable | Unknown | Eye & ENT Hospital of Fudan University | 72 | 2019-07-01 | 2019-07-24 |
| Prognosis of Vestibular Dysfunction in Patients With Idiopathic Sudden Sensorineural Hearing Loss ISSNHL with vertigo - Vestibular Disorder, Sudden Hearing Loss | Completed | Eye & ENT Hospital of Fudan University | 86 | 2019-05-15 | 2022-11-04 | |
| OSA and Sudden Sensorineural Hearing Loss ventilatory polygraphy - Obstructive Sleep Apnea, Sudden Hearing Loss | Not applicable | Completed | Poitiers University Hospital | 10 | 2018-11-19 | 2020-06-01 |
| Ischemia- Modified Albumin Levels in the Sudden Hearing Loss Ischemia-modified albumin, Hearing thresholds - Sudden Hearing Loss, Ischemia | Unknown | Yuzuncu Yil University | 60 | 2018-11-01 | 2018-10-17 | |
| What is the Tympanic Membrane Healing Time After Insertion of a Gelfoam PE Tube? PE tube - Eustachian Tube Dysfunction, Sudden Hearing Loss | Not applicable | Completed | Skovlund Medical Products, LLC | 14 | 2011-03-15 | 2021-05-26 |
Hearing Loss, Sudden (20) · Hearing Loss, Sensorineural (6) · Hearing Loss, Noise-Induced (4) · Hearing Loss (2) · Sleep Apnea, Obstructive (2) · Ischemia (1) · Meniere Disease (1) · Pain (1) · Presbycusis (1) · Tinnitus (1) · Vertigo (1) · Vestibular Diseases (1)
Ear Diseases (20) · Hearing Disorders (20) · Nervous System Diseases (20) · Neurologic Manifestations (20) · Otorhinolaryngologic Diseases (20) · Pathological Conditions, Signs and Symptoms (20) · Sensation Disorders (20) · Signs and Symptoms (20) · Hearing Loss (18) · Labyrinth Diseases (3) · Apnea (2) · Dyssomnias (2) · Respiration Disorders (2) · Respiratory Tract Diseases (2) · Sleep Apnea Syndromes (2)
Methylprednisolone (2) · Acupuncture Therapy (1) · Ginkgo biloba extract (1) · Hydroxychloroquine (1) · Methylprednisolone Hemisuccinate (1) · Prednisone (1) · Steroids (1) · ginaton (1)
Eye & ENT Hospital of Fudan University (4) · Frequency Therapeutics (3) · Tel-Aviv Sourasky Medical Center (2) · Yuzuncu Yil University (2) · Beijing Tsinghua Chang Gung Hospital (1) · Chang Gung Memorial Hospital (1) · China Medical University Hospital (1) · Guangdong Provincial People's Hospital (1) · Poitiers University Hospital (1) · Skovlund Medical Products, LLC (1) · The Affiliated Hospital of Qingdao University (1) · Truway Health, Inc. (1) · Wonju Severance Christian Hospital (1)
China (7) · United States (4) · Taiwan (2) · France (1) · South Korea (1) · Turkey (Türkiye) (1)
Carl LeBel, PhD (3) · Huawei Li, MD, Ph.D (2) · Yilai Shu, MD, Ph.D (2) · Chao-Hui Yang (1) · Gavin C Solomon, CEO (1) · Haijin Yi, MD (1) · Huawei Li, MD, PhD (1) · Huawei Li, Phd & MD (1) · Juanjuan Gao, MD (1) · Mu He, MD (1) · Sichao Liang, MA (1) · Tiffany Walker (1) · Wuqing Wang, MD, Ph.D (1) · Xin Cao, MA (1) · Xingxing Lu, MA (1)
PMID 25712982, PMID 26648996, PMID 27769665, PMID 28261890, PMID 32698830, PMID 37517037