9 not yet recruiting, 4 completed, 4 recruiting, 1 enrolling by invitation. 16 Not applicable, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 16 | Not yet recruiting 7, Completed 4, Recruiting 4, Enrolling by invitation 1 |
| Early Phase 1 | 1 | Not yet recruiting 1 |
Follow Substance Use (Drugs, Alcohol): new trials by email Literature Review of Substance Use (Drugs, Alcohol) trials Research Report on Substance Use (Drugs, Alcohol)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study Community Paramedic Standard of Care (CP SOC), CROSSROADS - Opioid Use Disorder, Overdose, Drug | Not applicable | Not yet recruiting | Duke University | 400 | 2027-02-01 | 2026-10-14 |
| VR Mindfulness for People With HIV and Substance Use TRIPP - HIV, Substance Use (Drugs, Alcohol) | Not applicable | Not yet recruiting | Tulane University | 30 | 2026-12-01 | 2026-10-13 |
| Transdiagnostic Sleep Intervention to Improve Mental Health in Adolescents Transdiagnostic Intervention for Sleep and Circadian Dysfunction, Healthy habits psychoeducation - Sleep Disturbance, Sleep Problems | Not applicable | Not yet recruiting | Universidad Pública de Navarra | 250 | 2026-10-09 | 2026-10-08 |
| Digital Intervention Delivered Via Street Medicine to Increase HIV and Substance Use Care Among Survivors of Sex Trafficking CONNECT - Sex Trafficking, HIV | Early Phase 1 | Not yet recruiting | Lifespan | 60 | 2026-10-05 | 2026-07-13 |
| The ICEC Cluster Trial: Integrated Community Engagement Collaborative for Youth Substance Use Prevention in Rural America Integrated Community Engagement Collaborative, School-Based Data Collection and Reporting without Network Coordinator Support - Substance Use (Drugs, Alcohol), Tobacco Use | Not applicable | Not yet recruiting | West Virginia University | 25000 | 2026-10-01 | 2026-09-28 |
| Mindfulness-based Relapse Prevention for Peer Workers Mindfulness Based Relapse Prevention, Standard of Care - Relapse/Recurrence, Substance Use (Drugs, Alcohol) | Not applicable | Recruiting | University of Texas at Austin | 80 | 2026-08-01 | 2026-08-07 |
| Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention ED-SMART intervention, Substance use information - Substance Use (Drugs, Alcohol) | Not applicable | Enrolling by invitation | Purdue University | 650 | 2026-06-17 | 2026-07-23 |
| The Trans-Led Care Study The TLC Program - Substance Abuse, Substance Addiction | Not applicable | Recruiting | Illinois Institute of Technology | 124 | 2026-04-14 | 2026-07-15 |
| Evaluation of the ADD'Pro Vocational Reintegration Program (ADD-PRO-EVAL) ADD'Pro Program, Standard Care (in control arm) - Addiction, Addiction Disorders | Not applicable | Not yet recruiting | University Hospital, Clermont-Ferrand | 100 | 2026-04-01 | 2026-04-09 |
| Nen ŨnkUmbi/EdaHiYedo Plus (We Are Here Now Plus): a Multi-level Intervention to Reduce Health Disparities Among American Indian Youth NE+, Control - Healthy, Condom Use | Not applicable | Recruiting | Montana State University | 843 | 2026-03-23 | 2026-05-12 |
| Options for Navigating Talking About Risk and Adolescent Choices ON-TRAC - Substance Use (Drugs, Alcohol), Substance Use Risk | Not applicable | Not yet recruiting | Rhode Island Hospital | 200 | 2026-03-01 | 2025-01-01 |
| Research and Evaluation of Link-Up, DCR in Brussels Self-reported questionnaire to monitor the consumption behaviors and sociodemographic characteristics - Substance Use (Drugs, Alcohol) | Not applicable | Not yet recruiting | Université Catholique de Louvain | 250 | 2026-03-01 | 2026-03-05 |
| Adaptation of the Family Check-Up Online Adapted Family Check-Up Online, Original Family Check-Up Online - Substance Use (Drugs, Alcohol) | Not applicable | Recruiting | University of Oregon | 108 | 2025-12-19 | 2026-06-04 |
| Optimizing HIV Pre-exposure Prophylaxis (PrEP) Among Women Who Use Drugs in Tanzania Motivational Interviewing for PreP, Common Elements Treatment Approach (CETA) + MI-PrEP - HIV, Mental Health | Not applicable | Completed | Johns Hopkins Bloomberg School of Public Health | 123 | 2025-07-25 | 2026-10-16 |
| Understanding Psychological Distress and Therapeutic Environment in the Emergency Department Routine Care - Mental Health, Substance Use (Drugs, Alcohol) | Not yet recruiting | NHS Fife | 398 | 2025-02-03 | 2024-12-12 | |
| A High School Program for Preventing Prescription Drug Misuse LST High School Hybrid - Prescription Drug Abuse, Substance Abuse | Not applicable | Completed | National Health Promotion Associates, Inc. | 1804 | 2022-02-01 | 2026-03-10 |
| International Latino Research Partnership Integrated Intervention for Dual Problems and Early Action - Substance Use (Drugs, Alcohol) | Not applicable | Completed | Massachusetts General Hospital | 360 | 2014-04-01 | 2017-05-01 |
| Life Skills Training Workplace Prevention Program Life Skills Training Workplace Prevention Program - Job Satisfaction, Work Performance | Not applicable | Completed | National Health Promotion Associates, Inc. | 1145 | 2007-02-01 | 2026-02-04 |
Substance-Related Disorders (18) · Psychological Well-Being (5) · Depression (2) · Acquired Immunodeficiency Syndrome (1) · Alcohol Drinking (1) · Anxiety Disorders (1) · Behavior, Addictive (1) · Burnout, Psychological (1) · Cigarette Smoking (1) · Coitus (1) · Drug Overdose (1) · Emotional Regulation (1) · Occupational Stress (1) · Opioid-Related Disorders (1) · Parasomnias (1)
Chemically-Induced Disorders (18) · Mental Disorders (18) · Behavior (13) · Personal Satisfaction (5) · Behavioral Symptoms (3) · Drug Misuse (2) · Social Behavior (2) · Blood-Borne Infections (1) · Communicable Diseases (1) · Compulsive Behavior (1) · Disease Attributes (1) · Drinking Behavior (1) · Genital Diseases (1) · HIV Infections (1) · Health Behavior (1)
Standard of Care (3) · Motivational Interviewing (1) · Sleep (1)
National Health Promotion Associates, Inc. (2) · Duke University (1) · Illinois Institute of Technology (1) · Johns Hopkins Bloomberg School of Public Health (1) · Lifespan (1) · Massachusetts General Hospital (1) · Montana State University (1) · NHS Fife (1) · Purdue University (1) · Rhode Island Hospital (1) · Tulane University (1) · Universidad Pública de Navarra (1) · University Hospital, Clermont-Ferrand (1) · University of Oregon (1) · University of Texas at Austin (1)
United States (10) · France (1) · Spain (1) · Tanzania (1) · United Kingdom (1)
Alfgeir L Kristjansson, PhD (1) · Audrey Hang Hai, PhD (1) · Christopher Williams, PhD, MPH (1) · Elizabeth L Rink, PhD, MSW (1) · Enrique Baca-Garcia, Ph.D. (1) · Francisco Collazos, MD (1) · Georges Brousse (1) · Haneefa T Saleem, PhD, MPH (1) · Jennifer L. Brown, PhD (1) · Jennifer L. Doty, PhD (1) · Julie Baldwin, PhD (1) · Lauren Brinkley-Rubinstein, PhD (1) · Margarita Alegria, Ph.D. (1) · Molly Secor, PhD (1)
PMID 30646205, PMID 30737609, PMID 41506761, PMID 41627337
K01DA065810 (1), R00DA055508 (1), R01DA034952 (1), R01DA063662 (1), R01MD012761 (1), R21DA061682 (1), R34DA058566 (1), R34DA061150 (1), R61DA059785 (1), RM1DA064518 (1), U01CE003825 (1)