6 completed, 3 withdrawn, 2 recruiting, 2 suspended. 17 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 17 | Completed 6, Withdrawn 3, Recruiting 2, Suspended 2, Terminated 2, Not yet recruiting 1, Unknown 1 |
| Phase 2 | 4 | Completed 1, Terminated 1, Unknown 1, Withdrawn 1 |
Follow Squamous Cell Lung Cancer: new trials by email Literature Review of Squamous Cell Lung Cancer trials Research Report on Squamous Cell Lung Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial of a Personalized and Adaptive Neoantigen Dose-Adjusted Vaccine Concurrently With Pembrolizumab PANDA-VAC, Pembrolizumab - Squamous Cell Lung Cancer, Squamous Non-small Cell Lung Cancer | Phase 1 | Suspended | UNC Lineberger Comprehensive Cancer Center | 6 | 2027-05-20 | 2026-04-23 |
| Phase Ib Study of Oral R01 Monotherapy in Advanced Solid Tumors R01 - Squamous Cell Lung Cancer, Gastric Cancer | Phase 1 | Not yet recruiting | Beijing Anjianxi Bio-Medical Technology Co., Ltd. | 18 | 2026-09-01 | 2026-09-08 |
| An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Advanced/Metastatic Squamous Cell Lung Cancer C-CAR031 - Squamous Cell Lung Cancer | Phase 1 | Recruiting | Shanghai AbelZeta Ltd. | 24 | 2024-12-25 | 2026-03-03 |
| A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of TT125-802 in Subjects With Advanced Solid Tumors TT125-802 - Advanced Solid Tumor, Adult Solid Tumor | Phase 1 | Completed | TOLREMO therapeutics AG | 45 | 2023-11-07 | 2026-07-07 |
| CISH Inactivated TILs in the Treatment of NSCLC Fludarabine, Cyclophosphamide, CISH Inactivated TIL - Carcinoma, Non-Small-Cell Lung, Metastatic Non Small Cell Lung Cancer | Phase 1 / Phase 2 | Withdrawn | Intima Bioscience, Inc. | 2023-02-01 | 2026-02-23 | |
| Phase I/II Study of Autologous T Cells to Express T-Cell Receptors (TCRs) in Subjects With Solid Tumors Neoantigen specific TCR-T cell drug product, Aldesleukin (IL-2) - Gynecologic Cancer, Colorectal Cancer | Phase 1 / Phase 2 | Terminated | Alaunos Therapeutics | 8 | 2022-04-04 | 2025-11-10 |
| Pirfenidone Combined With Standard First-Line Chemotherapy in Advanced-Stage Lung NSCLC Pirfenidone, Carboplatin, Paclitaxel - Lung Cancer, Non Small Cell Lung Cancer | Phase 1 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 48 | 2017-09-26 | 2025-12-05 |
| GPC3-CAR-T Cells for Immunotherapy of Cancer With GPC3 Expression GPC3 and/or TGFβ targeting CAR-T cells - Hepatocellular Carcinoma, Immunotherapy | Phase 1 | Recruiting | Second Affiliated Hospital of Guangzhou Medical University | 30 | 2017-07-01 | 2024-06-25 |
| A Study of AZD2014 in Combination With Selumetinib in Patients With Advanced Cancers AZD2014, AZD6244 - Triple-Negative Breast Cancer, Squamous Cell Lung Cancer | Phase 1 / Phase 2 | Unknown | Queen Mary University of London | 118 | 2015-06-01 | 2020-02-25 |
| Radiation Therapy, Chemotherapy, and Soy Isoflavones in Treating Patients With Stage IIIA-IIIB Non-Small Cell Lung Cancer soy isoflavones, cisplatin, etoposide - Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer | Phase 1 | Completed | Barbara Ann Karmanos Cancer Institute | 11 | 2014-08-01 | 2020-11-23 |
| Phase I IGART Study Using Active Breathing Control and Simultaneous Boost for Patients With NSCLC Paclitaxel, image-guided adaptive radiation therapy, carboplatin - Adenocarcinoma of the Lung, Large Cell Lung Cancer | Phase 1 | Withdrawn | Virginia Commonwealth University | 2014-03-01 | 2015-03-19 | |
| Pemetrexed Disodium and Hsp90 Inhibitor AUY922 in Treating Patients With Previously Treated Stage IV Non-Small Cell Lung Cancer Hsp90 inhibitor AUY922, pemetrexed disodium, pharmacological study - Recurrent Non-small Cell Lung Cancer, Squamous Cell Lung Cancer | Phase 1 | Completed | Jonsson Comprehensive Cancer Center | 13 | 2014-01-31 | 2020-09-03 |
| Docetaxel With or Without FGFR Inhibitor AZD4547 in Treating Patients With Recurrent Non-Small Cell Lung Cancer docetaxel, AZD4547 - Recurrent Non-small Cell Lung Cancer, Squamous Cell Lung Cancer | Phase 1 / Phase 2 | Completed | ECOG-ACRIN Cancer Research Group | 2 | 2014-01-15 | 2023-06-29 |
| Sirolimus and Gold Sodium Thiomalate in Treating Patients With Advanced Squamous Non-Small Cell Lung Cancer sirolimus, gold sodium thiomalate, pharmacological study - Recurrent Non-small Cell Lung Cancer, Squamous Cell Lung Cancer | Phase 1 | Withdrawn | Mayo Clinic | 2011-06-01 | 2020-04-01 | |
| Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on Cancer Autologous Natural Killer / Natural Killer T Cell Immunotherapy - Breast Cancer, Glioma | Phase 1 | Suspended | Envita Medical Center, Inc. | 24 | 2009-05-01 | 2010-02-24 |
| Photodynamic Therapy in Treating Patients With Lung Cancer HPPH, photodynamic therapy, therapeutic bronchoscopy - Adenocarcinoma of the Lung, Large Cell Lung Cancer | Phase 1 | Completed | Roswell Park Cancer Institute | 17 | 2004-02-01 | 2014-07-31 |
| Erlotinib and Radiation Therapy Plus Combination Chemotherapy in Treating Patients With Inoperable Stage III Non-Small Cell Lung Cancer cisplatin, etoposide, erlotinib hydrochloride - Adenocarcinoma of the Lung, Bronchoalveolar Cell Lung Cancer | Phase 1 | Terminated | National Cancer Institute (NCI) | 48 | 2002-05-01 | 2013-02-01 |
Carcinoma, Non-Small-Cell Lung (10) · Adenocarcinoma of Lung (6) · Adenocarcinoma, Bronchiolo-Alveolar (2) · Lung Neoplasms (2) · Neoplasms (2) · Pancreatic Neoplasms (2) · Breast Neoplasms (1) · Carcinoma, Hepatocellular (1) · Cholangiocarcinoma (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1) · Disease (1) · Endometrial Neoplasms (1) · Esophageal Neoplasms (1) · Glioma (1)
Neoplasms by Site (15) · Neoplasms (14) · Lung Diseases (11) · Respiratory Tract Diseases (11) · Respiratory Tract Neoplasms (11) · Thoracic Neoplasms (11) · Bronchial Neoplasms (10) · Carcinoma, Bronchogenic (10) · Lung Neoplasms (9) · Neoplasms by Histologic Type (9) · Neoplasms, Glandular and Epithelial (9) · Carcinoma (8) · Adenocarcinoma (7) · Digestive System Diseases (4) · Digestive System Neoplasms (4)
Carboplatin (3) · Paclitaxel (3) · Pemetrexed (3) · Cisplatin (2) · Docetaxel (2) · Etoposide (2) · Interleukin-2 (2) · Radiotherapy (2) · Taxes (2) · aldesleukin (2) · pembrolizumab (2) · 1-phenyl-3,3-dimethyltriazene (1) · 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (1) · 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide (1) · AZD 6244 (1)
Alaunos Therapeutics (1) · Barbara Ann Karmanos Cancer Institute (1) · Beijing Anjianxi Bio-Medical Technology Co., Ltd. (1) · ECOG-ACRIN Cancer Research Group (1) · Envita Medical Center, Inc. (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Intima Bioscience, Inc. (1) · Jonsson Comprehensive Cancer Center (1) · Mayo Clinic (1) · National Cancer Institute (NCI) (1) · Queen Mary University of London (1) · Roswell Park Cancer Institute (1) · Second Affiliated Hospital of Guangzhou Medical University (1) · Shanghai AbelZeta Ltd. (1) · TOLREMO therapeutics AG (1)
United States (11) · China (3) · Spain (1) · Switzerland (1) · United Kingdom (1)
Ann Mauer (1) · Charles Rudin (1) · David Korn, D.O., M.D. (1) · Edward Garon (1) · Elisabeth Weiss, MD (1) · Emil Lou, MD, PhD (1) · Erminia Massarelli, MD, PhD, MS (1) · Jared Weiss, MD (1) · Jhanelle Gray, M.D. (1) · Michael Menefee (1) · Peter Schmid, Professor (1) · Samjot Dhillon (1) · Scott Kopetz, MD, PhD (1) · Shirish Gadgeel (1) · Shun Lu, MD (1)
PMID 28123387, PMID 34325726, PMID 35537408
2014 (1), N01CM17102 (1), N01CM62201 (1), P30CA022453 (1), U10CA021115 (1)